Fig 2: Airway inflammation and AHR in an OVA-challenged mouse model. (A) The establishment of chronic asthma mouse model; (B) The level of Sema7a in serum of patients with asthma was higher than that in serum of healthy subjects. (C) The asthma group had higher IL-4 levels in the BALF than the control group and the anti-Sema7a group had lower IL-4 levels than the asthma group. (D) The asthma group had higher IL-5 levels in the BALF than the control group and the anti-Sema7a group had lower IL-4 levels than the asthma group. (E) The asthma group had higher IL-13 levels in the BALF than the control group and the anti-Sema7a group had lower IL-4 levels than the asthma group. (F) The asthma group had higher TGF-B 1 levels in the BALF than the control group and the anti-Sema7a group had lower IL-4 levels than the asthma group. (G) It does not reveal significant differences among the three groups of baseline airway responsiveness (at 0 mg/ml methacholine); Stimulated by acetylcholine, the C was significantly descended in asthma group compared with control group, while enhanced in anti-Sema7a group compared with asthma group. (H) Stimulated by acetylcholine, the R was significantly enhanced in asthma group compared with control group, while descended in anti-Sema7a group compared with asthma group. Data represent means ± SD. *P < 0.05, **P < 0.01.