IL-15 Antibody AF315 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-15 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF315
NCBI Gene AliasesIL-15
ApplicationsImmunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry
Quantity100 ug (also 25 ug)
TargetIL-15
HostGoat
ReactivityFeline,Human,Primate - Macaca mulatta (Rhesus Macaque)
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
IsotypeIgG
NCBI Full Gene Nameinterleukin 15
ClonalityPolyclonal
ImmunogenE. coli-derived recombinant human IL-15, Asn49-Ser162, Accession # P40933
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects human IL-15 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant mouse IL-15 is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein TranslationJournal of immunology (Baltimore, Md. : 1950)November 1, 2024Mullan CW, Summer L, Lopez-Giraldez F, Tobiasova Z, Manes TD, Yasothan S, Song G, Jane-Wit D, Saltzman WM, Pober JS.SC-8437, Sigma SAB2101148, R&D Systems MAB247, R&D Systems MAB2471, R&D Systems MAB2472, R&D Systems AF315, Abcam ab273625, Abcam 109082. Other antibodies trialed for surface flow cytometry staining are: Abcam

(2) A First-in-Human Phase I Study of Subcutaneous Outpatient Recombinant Human IL15 (rhIL15) in Adults with Advanced Solid TumorsClinical cancer research : an official journal of the American Association for Cancer ResearchApril 1, 2018Miller JS, Morishima C, McNeel DG, Patel MR, Kohrt HEK, Thompson JA, Sondel PM, Wakelee HA, Disis ML, Kaiser JC, et al.

(3) Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitismAbsAugust 1, 2017Vicari AP, Schoepfer AM, Meresse B, Goffin L, Léger O, Josserand S, Guégan N, Yousefi S, Straumann A, Cerf-Bensussan N, et al.

(4) Efficient production and enhanced tumor delivery of engineered extracellular vesiclesBiomaterialsOctober 1, 2016Watson DC, Bayik D, Srivatsan A, Bergamaschi C, Valentin A, Niu G, Bear J, Monninger M, Sun M, Morales-Kastresana A, et al.(System Biosciences; Mountain View, CA), αAlix (clone 3A9, LifeSpan Biosciences; Seattle, WA), αIL-15 (AF315, R&D Systems) and αIL-15Rα (AF247, R&D Systems). All blots were probed overnight at 4°C. Detection of

(5) Recombinant human heterodimeric IL-15 complex displays extensive and reproducible N- and O-linked glycosylationGlycoconjugate journalJune 1, 2016Thaysen-Andersen M, Chertova E, Bergamaschi C, Moh ES, Chertov O, Roser J, Sowder R, Bear J, Lifson J, Packer NH, et al.Western immunoblotting using anti-human IL-15 or anti-human IL-15Rα polyclonal goat IgG antibodies (product #AF315 and #AF247, respectively, R&D Systems). Release and handling of N- and O-glycans of human IL-15 and

(6) TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B CellsJournal of immunology (Baltimore, Md. : 1950)August 1, 2015Mongini PK, Gupta R, Boyle E, Nieto J, Lee H, Stein J, Bandovic J, Stankovic T, Barrientos J, Kolitz JE, et al.

(7) IL-15 amplifies the pathogenic properties of CD4+CD28- T cells in multiple sclerosisJournal of immunology (Baltimore, Md. : 1950)March 1, 2015Broux B, Mizee MR, Vanheusden M, van der Pol S, van Horssen J, Van Wijmeersch B, Somers V, de Vries HE, Stinissen P, Hellings N.

(8) Intramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cellsGene therapyJanuary 1, 2015Bergamaschi C, Kulkarni V, Rosati M, Alicea C, Jalah R, Chen S, Bear J, Sardesai NY, Valentin A, Felber BK, et al.Minneapolis, MN, USA) or by western immunoblot (using the polyclonal goat anti-human IL-15 antibody AF315, R&D Systems). Human IL-15Rα expression was analyzed by western immunoblot using polyclonal goat anti-human

(9) Secretion and Biological Activity of Short Signal Peptide IL-15 Is Chaperoned by IL-15 Receptor Alpha In VivoThe Journal of ImmunologySeptember 1, 2009Cristina Bergamaschi, Rashmi Jalah, Viraj Kulkarni, Margherita Rosati, Gen-Mu Zhang, Candido Alicea, Andrei S. Zolotukhin, Barbara K. Felber, George N. Pavlakisharvested and IL-15 expression was tested by Western blot, using the polyclonal goat anti-human IL-15 Ab (AF315; R&D Systems). Localization of IL-15/IL-15Rα complexes Twenty-four hours after transfection, human

(10) Enrichment and persistence of virus-specific CTL in the brain of simian immunodeficiency virus-infected monkeys is associated with a unique cytokine environmentJournal of immunology (Baltimore, Md. : 1950)May 1, 2007Marcondes MC, Burdo TH, Sopper S, Huitron-Resendiz S, Lanigan C, Watry D, Flynn C, Zandonatti M, Fox HS.

(11) Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanismJournal of immunology (Baltimore, Md. : 1950)February 15, 2005Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, Kufe D.

(12) Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanismJournal of immunology (Baltimore, Md. : 1950)February 15, 2005Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, Kufe D.

(13) Cloning and expression of feline interleukin 15CytokineJanuary 21, 2005Dean GA, Barger A, Lavoy A.

(14) NK cells regulate CD8+ T cell effector function in response to an intracellular pathogenJournal of immunology (Baltimore, Md. : 1950)January 1, 2004Vankayalapati R, Klucar P, Wizel B, Weis SE, Samten B, Safi H, Shams H, Barnes PF.

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IL-15 Antibody

IL-15 Antibody

IL-15 Antibody

IL-15 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (14)

Reviews

IL-15 Antibody from R&D Systems, a Bio-Techne Brand

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