Noggin Antibody AF719 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemNoggin Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $489.00Supplier Page View Company Product Page
Catalog NumberAF719
ApplicationsImmunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Functional Assay
HostGoat
Conjugate/TagUnconjugated
TargetNoggin
NCBI Full Gene Namenoggin
ReactivityHu, Ms, Rb, Rt, Ck
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse Noggin, Leu20-Cys232, Accession # P97466
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Gene AliasesSYNS1A, SYM1, SYNS1
PurityAntigen Affinity-purified
ConcentrationLYOPH
ClonalityPolyclonal
Quantity100 ug (also 25 ug)
IsotypeIgG
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse Noggin in direct ELISAs and Western blots. In direct ELISAs, approximately 30% cross-reactivity with recombinant human Noggin is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Loss of function of Noggin inhibits glial scar formation and motor function recovery after spinal cord injuryFrontiers in Neural CircuitsMay 28, 2026Yibo Han, Yuki Wakayama, Shuo Li, Dong Liang, Juntan Li, Yashuang Ping, Hideyuki Arima, Kohji Sato, Yukihiro Matsuyama, Satoru Yamagishianti-GFP (1:1,000; No. 598; MBL), rabbit anti-Noggin (1:350; ab16054, Abcam), goat anti-Noggin (1:500; AF719, R&D Systems), goat anti-Iba1 (1:1,000; ab107159, Abcam), rabbit anti-Ki67 (1:500; ab16667, Abcam),

(2) GREM1 acts in leptin receptor-expressing skeletal cells to mediate peri-implant fibrosisNature CommunicationsMarch 23, 2026Vincentius Jeremy Suhardi, Anastasia Oktarina, Yingzhen Niu, Andrew L. Thomson, Jϋrgen Alphonsus, Nicolas Suhardi, Jason McCormick, Ugur Ayturk, Matthew B. Greenblatt, Lionel B. Ivashkiv, et al.dilution), phospho Smad1/Smad5/Smad8 (EMD Milipore, AB3848-I, 1:100 dilution), Noggin (R&D System, AF719, 1:100 dilution), BMP2 (Abcam, ab214821, 1:100 dilution), BMP4 (Abcam, ab39973, 1:100 dilution), BMP6

(3) Taste papilla cell differentiation requires tongue mesenchyme via ALK3-BMP signaling to regulate the production of secretory proteinsbioRxiv : the preprint server for biologyApril 4, 2023Ishan M, Wang Z, Zhao P, Yao Y, Stice S, Wells L, Mishina Y, Liu HX.

(4) Myo/Nog Cells Give Rise to Myofibroblasts During Epiretinal Membrane Formation in a Mouse Model of Proliferative VitreoretinopathyInvestigative ophthalmology & visual scienceFebruary 1, 2023Crispin M, Gerhart J, Heffer A, Martin M, Abdalla F, Bravo-Nuevo A, Philp NJ, Kuriyan AE, George-Weinstein M.double labeling with the anti-BAI1 G8 IgM mouse mAb30 and the anti-noggin goat polyclonal anti-serum (AF719; R&D Systems, Minneapolis, MN, USA), as described previously.25,30 Double labeling also was carried

(5) Unveiling the transcriptomic landscape and the potential antagonist feedback mechanisms of TGF-β superfamily signaling module in bone and osteoporosisCell communication and signaling : CCSNovember 28, 2022Wang YW, Lin WY, Wu FJ, Luo CW.(Cell Signaling, 8828), total SMAD2/3 (Cell Signaling, 8685), total SMAD1 (Santa Cruz, sc-7965), NOG (R&D systems, AF719), GREM1 (R&D systems, AF956), GREM2 (R&D systems, AF2069) and β-actin (Chemicon, MAB1501). cDNA preparation

(6) A non-invasive method to generate induced pluripotent stem cells from primate urineScientific reportsFebruary 10, 2021Geuder J, Wange LE, Janjic A, Radmer J, Janssen P, Bagnoli JW, Müller S, Kaul A, Ohnuki M, Enard W.

(7) Acute Response and Neuroprotective Role of Myo/Nog Cells Assessed in a Rat Model of Focal Brain InjuryFrontiers in neuroscienceJanuary 1, 2021Joseph-Pauline S, Morrison N, Braccia M, Payne A, Gugerty L, Mostoller J, Lecker P, Tsai EJ, Kim J, Martin M, et al.

(8) Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aortaeLifeFebruary 24, 2020Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, et al.Cell Signaling Technologies, 2230), rat anti-VCAM1 (1:200, MilliporeSigma, CBL1300), goat anti-NOG (1:200, R and D systems, AF719), goat anti-CCL21 (1:200, R and D systems, AF457), goat anti-PROX1 (1:100, R and D systems, AF2727),

(9) Myo/Nog cells are nonprofessional phagocytesPloS oneJanuary 1, 2020Gerhart J, Gugerty L, Lecker P, Abdalla F, Martin M, Gerhart O, Gerhart C, Johal K, Bernstein J, Spikes J, et al.purified G8 IgM was used at a concentration of 3.6 μg/ml. The anti-Noggin goat polyclonal antiserum (AF719; R&D Systems, Minneapolis, MN), antiMyoD IgG1 mAb (MA5-12902, Thermo Fisher Scientific, Rockford, IL)

(10) Brain-specific angiogenesis inhibitor 1 is expressed in the Myo/Nog cell lineagePloS oneJanuary 1, 2020Gerhart J, Bowers J, Gugerty L, Gerhart C, Martin M, Abdalla F, Bravo-Nuevo A, Sullivan JT, Rimkunas R, Albertus A, et al.Double labeling also was performed with the R&D BAI1 mAb and the anti-Noggin goat polyclonal antiserum (AF719; R&D Systems), anti-MyoD IgG1 mAb (MA5-12902, ThermoFisher Scientific, Rockford, IL), anti-MyoD rabbit

(11) Noggin depletion in adipocytes promotes obesity in miceMolecular metabolismJuly 1, 2019Blázquez-Medela AM, Jumabay M, Rajbhandari P, Sallam T, Guo Y, Yao J, Vergnes L, Reue K, Zhang L, Yao Y, et al.(Gibco/Thermofisher Scientific, Waltham, MA). Recombinant human BMP4 and Noggin, and anti-Noggin antibodies (Cat. No. AF719) were from R&D Systems (Minneapolis, MN). The ASCs were sorted by FACS as outlined below. 2.3 Body fat

(12) Rhabdomyosarcoma and Wilms tumors contain a subpopulation of noggin producing, myogenic cells immunoreactive for lens beaded filament proteinsPloS oneJanuary 1, 2019Gerhart J, Behling K, Paessler M, Milton L, Bramblett G, Garcia D, Pitts M, Hurtt R, Crawford M, Lackman R, et al.double labeled with the G8 IgM mouse mAb [6] diluted 1:40 and a goat polyclonal antiserum to noggin (AF719; R&D Systems, Minneapolis, MN) diluted 1:100, rabbit polyclonal antisera to filensin [42] diluted 1:1000,

(13) Myo/Nog cells are present in the ciliary processes, on the zonule of Zinn and posterior capsule of the lens following cataract surgeryExperimental eye researchJune 1, 2018Gerhart J, Withers C, Gerhart C, Werner L, Mamalis N, Bravo-Nuevo A, Scheinfeld V, FitzGerald P, Getts R, George-Weinstein M.mAb diluted 1:40 (Gerhart et al., 2001), G8 and a goat polyclonal antiserum to noggin diluted 1:100 (AF719; R&D Systems, Minneapolis, MN), or combinations of G8 or noggin antibodies and mAbs to alpha smooth muscle

(14) Antibody-Conjugated, DNA-Based Nanocarriers Intercalated with Doxorubicin Eliminate Myofibroblasts in Explants of Human Lens TissueThe Journal of pharmacology and experimental therapeuticsApril 1, 2017Gerhart J, Greenbaum M, Casta L, Clemente A, Mathers K, Getts R, George-Weinstein M.in this study: G8 (Gerhart et al., 2001), alpha smooth muscle actin (a-SMA) (Sigma-Aldrich), noggin (AF719; R&D Systems, Minneapolis, MN), MyoD1 (NCL-MyoD1; Novocastra Laboratories Ltd, Newcastle Upon Tyne,

(15) Precise spatial restriction of BMP signaling is essential for articular cartilage differentiationDevelopment (Cambridge, England)March 15, 2015Ray A, Singh PN, Sohaskey ML, Harland RM, Bandyopadhyay A.anti-GAG (3C2; Potts et al., 1987), anti-pSMAD1/5/8 (Cell Signaling, 9511; 1:100) and anti-noggin (R&D Systems, AF719; 1:100). Following this step, tissues were washed in PBT and incubated with respective secondary antibodies, such

(16) Myo/Nog cells: targets for preventing the accumulation of skeletal muscle-like cells in the human lensPloS oneJanuary 1, 2014Gerhart J, Greenbaum M, Scheinfeld V, Fitzgerald P, Crawford M, Bravo-Nuevo A, Pitts M, George-Weinstein M.[25]. Double labeling was also performed with the G8 mAb and goat polyclonal antibodies to Noggin (AF719; R&D Systems, Minneapolis, MN, USA) and rabbit polyclonal antibodies to filensin [42] and CP49 [43],

(17) Joint TGF-β type II receptor-expressing cells: ontogeny and characterization as joint progenitorsStem cells and developmentMay 1, 2013Li T, Longobardi L, Myers TJ, Temple JD, Chandler RL, Ozkan H, Contaldo C, Spagnoli A.Santa Cruz Biotechnology, 1:100 dilution), Jagged1 (Sc-6011, Santa Cruz Biotechnology, 1:150 dilution), Noggin (AF719, R&D Systems, 15 mg/mL), GDF5 (AF853, R&D Systems, 10 mg/mL), Tenascin C (MAB3358, R&D Systems, 10 mg/mL),

(18) Myo/Nog cell regulation of bone morphogenetic protein signaling in the blastocyst is essential for normal morphogenesis and striated muscle lineage specificationDevelopmental biologyNovember 1, 2011Gerhart J, Scheinfeld VL, Milito T, Pfautz J, Neely C, Fisher-Vance D, Sutter K, Crawford M, Knudsen K, George-Weinstein M.(MS-295-PO, Thermo Scientific, Fremont, CA), and the following polyclonal antisera: goat anti-mouse noggin (AF719, R&D Systems, Minneapolis, MN), rabbit anti-mouse chordin (ab24562, Abcam, Cambridge, MA), goat anti-human

(19) BMP signalling permits population expansion by preventing premature myogenic differentiation in muscle satellite cellsCell death and differentiationFebruary 1, 2011Ono Y, Calhabeu F, Morgan JE, Katagiri T, Amthor H, Zammit PS.

(20) Noggin producing, MyoD-positive cells are crucial for eye developmentDevelopmental biologyDecember 1, 2009Gerhart J, Pfautz J, Neely C, Elder J, DuPrey K, Menko AS, Knudsen K, George-Weinstein M.

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Noggin Antibody

Noggin Antibody

Noggin Antibody

Noggin Antibody

Noggin Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (21)

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Noggin Antibody from R&D Systems, a Bio-Techne Brand

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