Gas6 Antibody AF986 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemGas6 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $529.00Supplier Page View Company Product Page
Catalog NumberAF986
ApplicationsELISA Development,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Frozen,ELISA Capture (Matched Antibody Pair),Immunocytochemistry
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
IsotypeIgG
ReactivityHuman,Mouse,Transgenic Mouse
HostGoat
Quantity100 ug (also 25 ug)
TargetGas6
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse Gas6 (R&D Systems, Catalog # 986-GS), Asp115-Pro673, Accession # CAA42507
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene Namegrowth arrest specific 6
NCBI Gene AliasesAXLLG, AXSF

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse Gas6 in ELISAs and Western blots. In sandwich immunoassays, less than 10% cross-reactivity with recombinant human Gas6 is observed and less than 1% cross-reactivity with recombinant mouse Gas1 is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Gut Commensal Klebsiella pneumoniae Extracellular Vesicles Shape a Liver Microenvironment Conducive to Gut‐Liver Bacterial Translocation and Pro‐Tumorigenic ProcessesJournal of Extracellular VesiclesApril 1, 2026Shogo Tsubaki, Sho Nashimoto, Rika Tanaka, Touya Toyomoto, Hiroyasu Tsutsuki, Ken Kato, Jun Nakayama, Kiminori Kimura, Kazuki Oshima, Yusuke Yamamoto, et al.Axl inhibitor (R428) (Abcam, cat. no. ab141364) and anti‐Gas6 (R&D Systems, Abingdon, UK, cat. no. AF986) and recombinant mouse Gas6 protein (R&D Systems, cat. no. 986‐GS) was used to examine the association

(2) Immune Niche Formation in Engineered Mouse Models Reveals Mechanisms of Tumor DormancybioRxivFebruary 9, 2026Abdul Ahad, Feng Leng, Hiroshi Ichise, Edward Schrom, Jae Young So, Carter Sellner, Yang Gu, Wenjuan Wang, Celine Kieu, Woo Yong Park, et al.permeabilized, and stained with conjugated with P-p38-PE (Invitrogen, #12-9078-42), GAS6 (R&D systems, #AF986), and SLURP1(abbexa, #abx129448) antibodies for 40 minutes. After washing, the samples were stained

(3) Immune Niche Formation Reveals Mechanisms of Tumor Dormancy and Targeting OpportunitiesResearchSquareFebruary 2, 2026Abdul Yang, Abdul Ahad, Hiroshi Ichise, Hiroshi Ichise, Jae Young Schrom, Jae Young Sellner, Carter Sellner, Wenjuan Wang, Wenjuan Wang, Woo Yong Kieu, et al.permeabilized, and stained with conjugated with P-p38-PE (Invitrogen, #12-9078-42), GAS6 (R&D systems, #AF986), and SLURP1(abbexa, #abx129448) antibodies for 40 minutes. After washing, the samples were stained

(4) Interaction between subventricular zone microglia and neural stem cells impacts the neurogenic response in a mouse model of cortical ischemic strokeNature communicationsOctober 24, 2024Nath S, Martínez Santamaría JC, Chu YH, Choi JS, Conforti P, Lin JD, Sankowski R, Amann L, Galanis C, Wu K, et al.600-401-379), mouse anti-iNOS (1:200, BD Bioscience, 610329), rabbit anti-Gas6 (1:25, R&D Systems, AF986), rat anti-Ki67 (1:200, Invitrogen, 14-5698-82), goat anti-ApoE (1:50, Invitrogen, PA1-26902), rabbit

(5) Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brainCancer cellOctober 14, 2024Gan S, Macalinao DG, Shahoei SH, Tian L, Jin X, Basnet H, Bibby C, Muller JT, Atri P, Seffar E, et al.anti-mAxl antibody,R&D Systems,Cat #:AF854RRID:AB_355663 Goat anti-mGas6 antibody,R&D Systems,Cat #: AF986-SPRRID:AB_3076301 Goat anti-hGas6 antibody,R&D Systems,Cat #: AF885-SPRRID:AB_3076302 Rabbit anti-Tenascin

(6) Gas6 and Protein S Ligands Cooperate to Regulate MerTK Rhythmic Activity Required for Circadian Retinal PhagocytosisInternational Journal of Molecular SciencesJune 16, 2024Célia Parinot, Jonathan Chatagnon, Quentin Rieu, Solène Roux, Dorine Néel, Florian Hamieh, Emeline F. Nandrotrecombinant proteins (mouse, 986-GS), as well as anti-mouse antibodies raised in goats against Gas6 (AF986) and MFG-E8 (AF2805), were from R&D Systems (Bio-Techne, Noyal-Châtillon-sur-Seiche, France). Recombinant

(7) Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liverPLoS pathogensJune 1, 2023Tsugawa H, Ohki T, Tsubaki S, Tanaka R, Matsuzaki J, Suzuki H, Hozumi K.986-GS) (used in administration experiments in mice), and an anti-Gas6 antibody (R&D Systems, cat# AF986) were used as Gas6/Axl signal modulators. Rhodamine phalloidin (Invitrogen, Waltham, MA, USA, R415)

(8) Adaptable toolbox to characterize Alzheimer's disease pathology in mouse modelsSTAR protocolsDecember 16, 2022Huang Y, Lemke G.DGS0213111, RRID: AB_2098565" "anti-mouse Gas6, polyclonal goat (For IF, 1:50–100)",R&D Systems,"Cat# AF986, lot: EFU0314121, RRID: AB_2263130" "anti-human-b-amyloid, 1–16 antibody, clone 6E10 (For IF, 1:1000)",Biolegend,"Cat#

(9) Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaquesImmunityMay 10, 2022Roy ER, Chiu G, Li S, Propson NE, Kanchi R, Wang B, Coarfa C, Zheng H, Cao W.AB_10129042) Goat anti-Mer,R&D Systems,Cat# AF591 (RRID: AB_2098565) Goat anti-Gas6,R&D Systems,Cat# AF986 (RRID: AB_2263130) Anti-APP CTD,"Hui Zheng lab (Xia et al, 2002)",N/A Mouse anti-γ-tubulin (clone

(10) Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer's diseaseJournal of neuroinflammationFebruary 7, 2022Owlett LD, Karaahmet B, Le L, Belcher EK, Dionisio-Santos D, Olschowka JA, Elliott MR, O'Banion MK.

(11) AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant LeukemiaCancer discoveryNovember 1, 2021Tirado-Gonzalez I, Descot A, Soetopo D, Nevmerzhitskaya A, Schäffer A, Kur IM, Czlonka E, Wachtel C, Tsoukala I, Müller L, et al.dilutions: anti-AXL (#AF854, R&D Systems; 1:50); anti-phospho AXL (#AF2228, R&D Systems; 1:50); anti-GAS6 (#AF986, R&D Systems; 1:50); anti-GFP (#ab13970, Abcam; 1:500); anti-Iba1 (rabbit; #019-19741, Wako Chemicals;

(12) Microglia use TAM receptors to detect and engulf amyloid β plaquesNature immunologyMay 1, 2021Huang Y, Happonen KE, Burrola PG, O'Connor C, Hah N, Huang L, Nimmerjahn A, Lemke G.

(13) Differential regulation of hepatic physiology and injury by the TAM receptors Axl and MerLife science allianceAugust 1, 2020Zagórska A, Través PG, Jiménez-García L, Strickland JD, Oh J, Tapia FJ, Mayoral R, Burrola P, Copple BL, Lemke G.Santa Cruz), GAPDH (MAB374, clone 6C5; Millipore), phospho-tyrosine (clone 4G10; Millipore), Gas6 (AF986; R&D Systems), CD31 (ab28364; Abcam), MARCO (MCA1849; AbD Serotec), Laminin (L9393; Sigma-Aldrich),

(14) Diverse Macrophage Populations Contribute to the Inflammatory Microenvironment in Premalignant Lesions During Localized InvasionFrontiers in oncologyJanuary 1, 2020Ibrahim AM, Moss MA, Gray Z, Rojo MD, Burke CM, Schwertfeger KL, Dos Santos CO, Machado HL.AF2125), CSFR1 (1:15 R&D Systems, AF3818), CD206 (1:1000, Abcam ab64693), and Gas6 (1:200 R&D Systems, AF986) at 4◦ C overnight. Slides were stained with Alexa Fluor-conjugated secondary antibodies (1:400; Thermo

(15) Gamma-glutamyl carboxylated Gas6 mediates the beneficial effect of vitamin K on lowering hyperlipidemia via regulating the AMPK/SREBP1/PPARα signaling cascade of lipid metabolismThe Journal of nutritional biochemistryAugust 1, 2019Bordoloi J, Ozah D, Bora T, Kalita J, Manna P.

(16) GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosaProceedings of the National Academy of Sciences of the United States of AmericaJanuary 17, 2017Nassar M, Tabib Y, Capucha T, Mizraji G, Nir T, Pevsner-Fischer M, Zilberman-Schapira G, Heyman O, Nussbaum G, Bercovier H, et al.

(17) Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinaseCell communication and signaling : CCSSeptember 6, 2016Kimani SG, Kumar S, Davra V, Chang YJ, Kasikara C, Geng K, Tsou WI, Wang S, Hoque M, Boháč A, et al.(Cell Signaling, MAB374), and anti-phosphotyrosine pY99 (Millipore, 05–321), anti-hGas6 (R&D Systems, AF986), Human EGF (Invitrogen, PHG0311). The secondary antibodies used for immunoblot analysis were horseradish

(18) TAM receptors regulate multiple features of microglial physiologyNatureApril 14, 2016Fourgeaud L, Través PG, Tufail Y, Leal-Bailey H, Lew ED, Burrola PG, Callaway P, Zagórska A, Rothlin CV, Nimmerjahn A, et al.described previously39. Antibodies used were as follows: anti-Mer (AF591), anti-Axl (AF854), and anti-Gas6 (AF986) were from R&D Systems, anti-Mer (DS5MMER) from eBioscience, anti-Iba1 (019-19741) was from Wako, anti-GFAP

(19) Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's diseaseThe Journal of neuroscience : the official journal of the Society for NeuroscienceApril 22, 2015Savage JC, Jay T, Goduni E, Quigley C, Mariani MM, Malm T, Ransohoff RM, Lamb BT, Landreth GE.

(20) Diversification of TAM receptor tyrosine kinase functionNature immunologyOctober 1, 2014Zagórska A, Través PG, Lew ED, Dransfield I, Lemke G.

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Gas6 Antibody

Gas6 Antibody

Gas6 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (27)

Reviews

Gas6 Antibody from R&D Systems, a Bio-Techne Brand

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