CTLA-4 Antibody AF-386-PB from R&D Systems, a Bio-Techne Brand

Product Specs
ItemCTLA-4 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $529.00Supplier Page View Company Product Page
Catalog NumberAF-386-PB
ApplicationsFlow Cytometry,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vivo assay,Immunocytochemistry,CyTOF-ready
TargetCTLA-4
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
HostGoat
ReactivityHuman,Rat,Xenograft
Conjugate/TagUnconjugated
IsotypeIgG
Quantity100 ug (also 25 ug)
ClonalityPolyclonal
ImmunogenS. frugiperda insect ovarian cell line Sf 21-derived recombinant human CTLA-4, Ala37-Phe162, Accession # Q6GR94
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene Namecytotoxic T-lymphocyte associated protein 4
NCBI Gene AliasesALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects human CTLA-4 in direct ELISAs and Western blots. In Western blots, approximately 25% cross-reactivity with recombinant mouse CTLA-4 is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Periparturient blood T-lymphocyte PD-1 and CTLA-4 expression as potential predictors of new intramammary infections in dairy cows during early lactation (short communication)BMC veterinary researchApril 20, 2024Oliveira ACD, de Souza CMS, Ramos-Sanchez EM, Diniz SA, de Souza Lima E, Blagitz MG, Veras RC, Heinemann MB, Libera AMMPD, De Vliegher S, et al.University Monoclonal Antibody Center, USA) and goat anti-human CTLA-4 cross-reactive with cattle (cat. n. AF-386-PB, R&D Systems, USA) or goat anti-human PD-1 with cross-reaction with cattle (cat. no. LS-C55247-100,

(2) Brief Research Report: Expression of PD-1 and CTLA-4 in T Lymphocytes and Their Relationship With the Periparturient Period and the Endometrial Cytology of Dairy Cows During the Postpartum PeriodFrontiers in veterinary scienceJanuary 1, 2022de Souza CMS, Lima ES, Ordonho RF, Oliveira BRRDS, Rodrigues RC, de Moura MF, Lima DM, Blagitz MG, Ramos Sanchez EM, de Medeiros IA, et al.in PBS with 1% heat-inactivated sterile-filtered fetal bovine serum and 0.09% sodium azide; cat. n. AF-386-PB, R&D Systems, USA). After the incubation period, the cells were washed with PBS and centrifuged at 250

(3) Natural killer cells in the human lung tumor microenvironment display immune inhibitory functionsJournal for immunotherapy of cancerOctober 1, 2020Russick J, Joubert PE, Gillard-Bocquet M, Torset C, Meylan M, Petitprez F, Dragon-Durey MA, Marmier S, Varthaman A, Josseaume N, et al.with mouse anti-human NKp46 (clone 195314, R&D Systems, 5 µg/mL) and/or goat anti-human CTLA4 mAb (AF-386-PB, R&D Systems, 2.5 µg/mL) for 1 hour at room temperature. Peroxidase-linked secondary antibody (ImmPress

(4) CTLA-4 Immunohistochemistry and Quantitative Image Analysis for Profiling of Human CancersThe journal of histochemistry and cytochemistry : official journal of the Histochemistry SocietyDecember 1, 2019Brown C, Sekhavati F, Cardenes R, Windmueller C, Dacosta K, Rodriguez-Canales J, Steele KE.T-lymphocytes that express CTLA-4 in selected lymphoid and cancer tissues. The PC assay used a PC (AF-386-PB; R&D Systems, Minneapolis, MN) directed at recombinant human CTLA-4 applied on a Discovery Ultra staining

(5) Antibody and fragment-based PET imaging of CTLA-4+ T-cells in humanized mouse modelsAmerican journal of cancer researchJanuary 1, 2019Ehlerding EB, Lee HJ, Jiang D, Ferreira CA, Zahm CD, Huang P, Engle JW, McNeel DG, Cai W.

(6) CTLA-4⁺PD-1^- Memory CD4⁺ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus MacaquesImmunityOctober 17, 2017McGary CS, Deleage C, Harper J, Micci L, Ribeiro SP, Paganini S, Kuri-Cervantes L, Benne C, Ryan ES, Balderas R, et al.rabbit polyclonal anti-PD-1 (1:200; Cat#HPA035981; SIGMA) and goat polyclonal anti-hCTLA-4 (1:200; Cat#AF-386-PB; R&D Systems). Slides were washed, incubated with secondary donkey anti-goat IgG-Alexa 488 and anti-rabbit

(7) PD-L1 expression and its relationship with oncogenic drivers in non-small cell lung cancer (NSCLC)OncotargetApril 18, 2017Jiang L, Su X, Zhang T, Yin X, Zhang M, Fu H, Han H, Sun Y, Dong L, Qian J, et al.antibody (790-4430, Ventana Medical Systems) and a goat anti-CTLA-4 monoclonal antibody (2.5ug/ml, AF-386-PB, R&D systems) using a Ventana automatic immunostainer (Discovery XT/Ultra; Ventana Medical Systems).

(8) Highly efficient, in-vivo Fas-mediated apoptosis of B-cell lymphoma by hexameric CTLA4-FasLJournal of hematology & oncologySeptember 17, 2014Aronin A, Amsili S, Prigozhina TB, Tzdaka K, Shen R, Grinmann L, Szafer F, Edebrink P, Rauvola MA, Shani N, et al.After blocking (skim milk) membranes (PVDF) were incubated with either goat anti-human CTLA4 antibody (AF-386-PB, R&D Systems, 1:300 dilution) or goat anti-human Fas Ligand (AB126, R&D Systems, 1:100 dilution). The

(9) Inhibitory receptors are expressed by Trypanosoma cruzi-specific effector T cells and in hearts of subjects with chronic Chagas diseasePloS oneJanuary 1, 2012Argüello RJ, Albareda MC, Alvarez MG, Bertocchi G, Armenti AH, Vigliano C, Meckert PC, Tarleton RL, Laucella SA.

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Human CTLA-4 Antibody

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CTLA-4 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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CTLA-4 Antibody from R&D Systems, a Bio-Techne Brand

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