APP Pan Specific Antibody AF1168 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemAPP Pan Specific Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF1168
NCBI Gene AliasesCTFgamma, CVAP, AAA, ABETA, AD1, PN-II, preA4, PN2, ABPP, APPI, alpha-sAPP
ApplicationsELISA Development,Immunohistochemistry,Western Blot
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
TargetAPP
HostGoat
Conjugate/TagUnconjugated
Quantity100 ug (also 25 ug)
ReactivityHuman,Mouse
IsotypeIgG
NCBI Full Gene Nameamyloid beta precursor protein
ClonalityPolyclonal
ImmunogenS. frugiperda insect ovarian cell line Sf 21-derived recombinant human APP 695+1 frameshift mutant, Leu18-Arg336, Accession # NP_958817
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects human APP695+1 and human APP770 in direct ELISAs and Western blots. This antibody recognizes a common epitope present on APP695+1 and APP770 found within the segments Leu18 - Arg288 or Pro365 - Arg411 of APP770 (Accession P05067).

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Discovery of an APP-selective BACE1 inhibitor for Alzheimer's diseaseNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeuticsSeptember 1, 2025Campagna J, Jagodzinska B, Wi D, Zhu C, Lee J, Cohn W, Jun M, Elias C, Padder S, Descamps O, et al.assayed using an AlphaLISA for Aβ1-42 (Perkin Elmer catalog # AL276C), sAPPα (R&D Systems catalog # AF1168 conjugated with Perkin Elmer acceptor beads catalog # 6772001 + 2B3 antibody from IBL catalog # 11088

(2) A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse modelScientific reportsDecember 4, 2018Campagna J, Spilman P, Jagodzinska B, Bai D, Hatami A, Zhu C, Bilousova T, Jun M, Elias CJ, Pham J, et al.the latter an anti-sAPPβ antibody (IBL Cat. #18957) and an anti-N-terminal APP antibody (R&D Systems AF1168) instead of anti-SirT1 antibodies. Brain tissue and plasma were sent to IAS for A03 level analysis. Statistical

(3) Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor proteinThe Journal of neuroscience : the official journal of the Society for NeuroscienceJanuary 2, 2013Gustafsen C, Glerup S, Pallesen LT, Olsen D, Andersen OM, Nykjær A, Madsen P, Petersen CM.with primary antibodies; anti-sortilin/F11 and anti-SorLA/20C11, anti-sortilin/ AF2934 and anti-APP/AF1168 (R&D Systems), anti-TGN46/AHP500 (Adb Serotec), anti-LAMP1/ab24170 (Abcam), anti-neurofilament 200/ N4142

(4) Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease miceCell reportsJanuary 1, 0001"Kiani Shabestari S, Morabito S, Danhash EP, McQuade A, Sanchez JR, Miyoshi E, Chadarevian JP, Claes C, Coburn MA, Hasselmann J, et al."

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APP Pan Specific Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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APP Pan Specific Antibody from R&D Systems, a Bio-Techne Brand

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