Human ADAM8 Ectodomain Antibody AF1031 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemHuman ADAM8 Ectodomain Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $519.00Supplier Page View Company Product Page
Catalog NumberAF1031
NCBI Gene AliasesCD156a, CD156, MS2
ApplicationsNative SDS-PAGE,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Neutralization,Immunocytochemistry
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
IsotypeIgG
TargetADAM8
Quantity100 ug (also 25 ug)
ReactivityHuman
HostGoat
NCBI Full Gene NameADAM metallopeptidase domain 8
ClonalityPolyclonal
ImmunogenS. frugiperda insect ovarian cell line Sf 21-derived recombinant human ADAM8 Ectodomain, Glu158-Ser653, Accession # P78325
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) A Novel Class of Human ADAM8 Inhibitory Antibodies for Treatment of Triple-Negative Breast CancerPharmaceuticsApril 13, 2024Mineva ND, Pianetti S, Das SG, Srinivasan S, Billiald NM, Sonenshein GE.(0.1–10 μg/mL). As negative and positive controls, 1 μg/mL normal mouse IgG and goat anti-mouse ADAM8 Ab (AF1031, R&D Systems, RRID: AB_354549), respectively, were analyzed. Alexa Fluor 488 donkey anti-mouse IgG (1:1000,

(2) RNA Aptamer Targeting of Adam8 in Cancer Growth and MetastasisCancersJune 20, 2023Mi Z, Kuo MC, Kuo PC.treated with Adam8 immunodepletion medium: The human Adam8 antibody (R&D Systems, Minneapolis, MN, USA, AF1031) was used to immunodeplete the Adam8 soluble domain from the co-culture medium of MDA-MB-231 and MSC

(3) ADAM8 signaling drives neutrophil migration and ARDS severityJCI insightFebruary 8, 2022Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, et al.used: ADAM8 was labeled using a goat polyclonal antibody against the ectodomain (1:100; R&D Systems, AF1031); for detection of Myo1f, a rabbit polyclonal antibody directed against the N-terminal domain (1:100;

(4) Cohort Analysis of ADAM8 Expression in the PDAC Tumor StromaJournal of personalized medicineFebruary 10, 2021Jaworek C, Verel-Yilmaz Y, Driesch S, Ostgathe S, Cook L, Wagner S, Bartsch DK, Slater EP, Bartsch JW.Antibody,Species,Working Dilution,Source ADAM8,rabbit,1:200,R&D Systems (AF1031) CD3,mouse,1:50,Dako (M7254) CD56,mouse,1:10,Monosan (MON 9006) CD68,mouse,1:200,Novus Biologicals

(5) ADAM8 affects glioblastoma progression by regulating osteopontin-mediated angiogenesisBiological chemistryJanuary 27, 2021Li Y, Guo S, Zhao K, Conrad C, Driescher C, Rothbart V, Schlomann U, Guerreiro H, Bopp MH, König A, et al.antibodies (CD11b: Thermo Fisher, MA1-80091; mouse ADAM8: Biorbyt, orb4376; human ADAM8: R&D Systems, AF1031). Angiogenesis tube formation assay 1 × 106 macrophages/U87 cells (ADAM8 deﬁcient compared to respective

(6) Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progressionScientific reportsSeptember 15, 2017Theodorou K, van der Vorst EPC, Gijbels MJ, Wolfs IMJ, Jeurissen M, Theelen TL, Sluimer JC, Wijnands E, Cleutjens JP, Li Y, et al.paraformaldehyde and paraffin embedded. Sections were incubated with a primary antibody against human ADAM8 (AF1031, R&D systems), followed by detection with a biotin-labelled rabbit anti-goat antibody (E0466, Dako)

(7) The metalloproteinase ADAM8 promotes leukocyte recruitment in vitro and in acute lung inflammationAmerican journal of physiology. Lung cellular and molecular physiologySeptember 1, 2017Dreymueller D, Pruessmeyer J, Schumacher J, Fellendorf S, Hess FM, Seifert A, Babendreyer A, Bartsch JW, Ludwig A.345913), human ␣5-integrin/CD49e (clone 230307); and goat polyclonal antibody against ADAM8 ectodomain (AF1031), goat IgG isotype control, mouse IgG2B isotype control (PerCP-labeled), and mouse IgG1 isotype control

(8) ADAM8 as a drug target in pancreatic cancerNature communicationsJanuary 28, 2015Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia AM, Höfling S, Parsons M, Costa P, Soper R, et al.immunoprecipitation and native gel electrophoresis, an antibody against the ectodomain of ADAM8 (R&D Systems, AF1031, 1:1000), for detection of human ADAM8 in western blots, we used an antibody against the cytoplasmic

(9) Fibronectin fragments and the cleaving enzyme ADAM-8 in the degenerative human intervertebral discSpineJuly 15, 2014Ruel N, Markova DZ, Adams SL, Scanzello C, Cs-Szabo G, Gerard D, Shi P, Anderson DG, Zack M, An HS, et al.different people (n = 17). For ADAM-8 Western blotting, goat anti-human ADAM-8 antibody at 0.2μg/ml (AF1031, R&D Systems) was incubated overnight at 4°C. Recombinant human ADAM-8 (R&D Systems) was used as positive

(10) Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinomaClinical cancer research : an official journal of the American Association for Cancer ResearchApril 1, 2010Stokes A, Joutsa J, Ala-Aho R, Pitchers M, Pennington CJ, Martin C, Premachandra DJ, Okada Y, Peltonen J, Grénman R, et al.

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ADAM8 Ectodomain Antibody

ADAM8 Ectodomain Antibody

ADAM8 Ectodomain Antibody

Human ADAM8 Ectodomain Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (10)

Reviews

Human ADAM8 Ectodomain Antibody from R&D Systems, a Bio-Techne Brand

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