IGF-I R/IGF1R Antibody AF-305-NA from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIGF-I R/IGF1R Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $539.00Supplier Page View Company Product Page
Catalog NumberAF-305-NA
NCBI Gene AliasesIGFR, IGFIR, CD221, JTK13
ApplicationsLuciferase Reporter Assay,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry,Functional Assay,Cell Culture
Conjugate/TagUnconjugated
ReactivityHuman,Mouse,Rabbit,Rat,Transgenic Mouse
Quantity100 ug (also 25 ug)
TargetIGF-I R/IGF1R
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
IsotypeIgG
HostGoat
NCBI Full Gene Nameinsulin like growth factor 1 receptor
ClonalityPolyclonal
ImmunogenRecombinant Human IGF-I R/IGF1R extracellular domain, Accession # P08069
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects human and mouse IGF-I R/IGF1R in direct ELISAs and Western blots. In direct ELISAs and Western blots, 25-50% cross-reactivity with recombinant mouse IGF-I R is observed. In direct ELISAs, less than 1% cross-reactivity with recombinant human IGF-II R is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Dual inhibition of intercellular adhesion molecule-1 and nucleolin reduces RSV infection efficiency in human respiratory organoidsMolecular Therapy Nucleic AcidsJune 16, 2026Abeer Keshta, Rina Hashimoto, Yuki Kitai, Yoshitaka Nakata, Ayaka Sakamoto, Shimpei Gotoh, Makoto Takeda, Kazuo Takayamacontaining anti-NCL antibodies (Cat# SC-8031, Santa Cruz Biotechnology), anti-IGF1R antibodies (Cat# AF-305-NA, R&D Systems), anti-ICAM-1 antibodies (Cat# RSD-AF720, R&D Systems), or IgG control (Cat# AB-108-C,

(2) SSTNIV, a syndecan-1-targeting peptide chimera, reverses immune suppression and inhibits myeloma progressionSignal Transduct Target TherMay 12, 2026Oisun Jung, DeannaLee M. Beauvais, Gavril L. Ibaan, Colin C. Wooldrik, Evan Flietner, Suyong Choi, Jing Zhang, Alan C. RapraegerCell Signaling Technology), phospho-ASK-1 (3765S, 3764S; Bioss), αv integrin (NBP1-85746; Novus), and IGF1R (33255, AF-305-NA; R&D Systems) were used. The TUNEL kit (ab206386) was from Abcam. AlexaFluor-conjugated secondary antibodies

(3) Rexinoid NEt-3IB Promotes Resident Macrophage Gene Expression and Mitigates Desiccation-Induced Ocular Surface DiseaseInvest Ophthalmol Vis SciApril 14, 2026Jehan Alam, Yangluowa Qu, Jianming Shao, Ebru Yaman, Karen Zheng, Hiroki Kakuta, Stephen C. Pflugfelderprimary antibodies were used: βIII-tubulin (ab215037; Abcam, Cambridge, UK) and human/mouse IGF-1R (AF-305-NA; R&D Systems, Minneapolis, MN, USA). After overnight incubation, tissues were washed three times for

(4) The role of IGF-2 and its variants in enhancing endothelial migration and angiogenesisFront Cell Dev BiolMay 16, 2025Lotte Alders, Elke Pirlet, Emma Gesquiere, Annelies Bronckaers555,1:500,"A21432 (RRID:AB_141788)Life Technologies (Carlsbad, CA, United States)" Mouse anti-IGF-R2,1:100,"AF-305- NA (RRID:AB_354457)R&D systems (Bio-Techne, Minneapolis, MN, United States)",Donkey anti-mouseAlexa FluorTM

(5) Gene proteins, growth factors/their receptors in the wall of chronic calculous cholecystitis-affected gallbladder childrenBMC pediatricsApril 12, 2025Derbeneva D, Pilmane M, Petersons A.,Santa Cruz Biotechnology,1:100 Anti-HGF antibody,ab216623,Polyclonal,United Kingdom,Abcam,1:200 Anti-human IGF-1 R antibody,AF-305-NA,Polyclonal,Germany,R&D Systems,1:200 Anti-IGF1 antibody,ab9572,Polyclonal,United Kingdom,Abcam,1:100 HOXB3

(6) Choroid plexus extracellular vesicle transport of blood-borne insulin-like growth factor 1 to the hippocampus of the immature brainPNAS NexusNovember 28, 2024Niklas Ortenlöf, Suvi Vallius, Helena Karlsson, Claes Ekström, Amanda Kristiansson, Bo Holmqvist, Stanislava Pankratova, Norman Barton, David Ley, Magnus GramWoburn, MA, USA), IGF-1 (1:100, goat antimouse, AF791, R&D systems), IGF-1R (1:20, goat antimouse, AF-305-NA, R&D systems), ZO-1 (1:50, rabbit antimouse, 61-7300, Thermo Fisher Scientific, Waltham, MA, USA), donkey

(7) Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1bioRxiv : the preprint server for biologyOctober 20, 2024Yu D, Jain S, Wangzhou A, De Florencio S, Zhu B, Kim JY, Choi JJ, Paredes MF, Nowakowski TJ, Huang EJ, et al.

(8) The pro-atherogenic enzyme PAPP-A is active in eluates from human carotid and femoral atherosclerotic plaquesAtherosclerosis PlusSeptember 5, 2024Mette Faurholdt Gude, Rikke Hjortebjerg, Mette Bjerre, Anne Kathrine Nissen Pedersen, Claus Oxvig, Lars Melholt Rasmussen, Jan Frystyk, Lasse Steffensenpreviously [31], used at 5 μg/mL), STC2 (Abcam, Cat# ab255610, diluted 1:100), and IGF1R (R&D Systems, Cat# AF-305-NA, diluted 1:200). Detection was performed using the full-automated OptiView DAB IHC Detection Kit (8-8)

(9) Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent mannerDevelopmental CellFebruary 5, 2024Jean-Francois Darrigrand, Anna Salowka, Alejo Torres-Cano, Rafael Tapia-Rojo, Tong Zhu, Sergi Garcia-Manyes, Francesca M. SpagnoliU3254), Glucagon (1:500, Immunostar Inc. 20076), Igf1 (1:300, Biotechne AF791), Igf1r (1:200, Biotechne AF305-NA), Insulin (1:2, Dako IR002), Integrin-α6 (1:400, Millipore MAB1378), Laminin-α1 (1:500, kindly provided

(10) Actin cytoskeleton remodeling disrupts physical barriers to infection and presents entry receptors to respiratory syncytial virusThe Journal of general virologyNovember 1, 2023Kieser QJ, Granoski MJ, McClelland RD, Griffiths C, Bilawchuk LM, Stojic A, Elawar F, Jamieson K, Proud D, Marchant DJ.Tyr1135 [DA7A8] (CST, 3918), anti-PKCζ [H-1] (Santa Cruz, sc-17781), anti-IGF1R polyclonal (R and D, AF-305-NA), anti-EEA1 [C45B10] (CST, 3288), MUC5AC monoclonal (Sigma, MAB2011) and normal goat control IgG (R and D

(11) IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathyCell reportsAugust 29, 2023Pan L, Cho KS, Wei X, Xu F, Lennikov A, Hu G, Tang J, Guo S, Chen J, Kriukov E, et al.

(12) Insulin-like Growth Factor 1, Growth Hormone, and Anti-Müllerian Hormone Receptors Are Differentially Expressed during GnRH Neuron DevelopmentInternational journal of molecular sciencesAugust 22, 2023Paganoni AJJ, Cannarella R, Oleari R, Amoruso F, Antal R, Ruzza M, Olivieri C, Condorelli RA, La Vignera S, Tolaj F, et al.goat anti-GHR (1:20; R&D Systems, Udine, Italy, cat. AF1360), goat anti-IGF1R (1:20; R&D Systems, cod. AF305-NA), rabbit anti-GnRH (1:400; Immunostar, Hudson, WI, USA, cat. 20075), goat anti-PLXND1 (1:200; R&D Systems,

(13) Characterization of choroid plexus in the preterm rabbit pup following subcutaneous administration of recombinant human IGF-1/IGFBP-3Fluids and barriers of the CNSAugust 15, 2023Ortenlöf N, Vallius S, Karlsson H, Ekström C, Kristiansson A, Holmqvist B, Göransson O, Vaváková M, Rydén M, Carey G, et al.cocktail of primary antibodies against IGF-1R (goat polyclonal IgG, 2 µg/ml, diluted in PBS-TX-BSA, AF-305-NA, R&D System, McKinley Place, MN, USA) and IGF-1 (mouse monoclonal IgG, 2 µg/ml, diluted in PBS-TX-BSA,

(14) A possible function of Nik-related kinase in the labyrinth layer of delayed delivery mouse placentasThe Journal of reproduction and developmentFebruary 8, 2023Yomogita H, Ito H, Hashimoto K, Kudo A, Fukushima T, Endo T, Hirate Y, Akimoto Y, Komada M, Kanai Y, et al.AF4666, 1:200), goat anti-proliferin (R&D Systems, AF1623, 1:200), and goat anti-IGF1r (R&D Systems, AF305-NA, 1:200), which were incubated overnight at 4°C. The secondary antibodies used were Alexa Fluor® 488

(15) Inhibiting IGF1R-mediated Survival Signaling in Head and Neck Cancer with the Peptidomimetic SSTN(IGF1R)Cancer Res CommunJanuary 1, 2023Stueven NA, Beauvais DM, Hu R, Kimple RJ, Rapraeger AC.(ITGAV) from Novus Biologicals; IGF1R-specific JBW902 (EMD Millipore), mAb 33255 (R&D Systems) and AF-305-NA from R&D Systems; JY202 (EMD Millipore), and Alexa647-conjugated mouse mAb K74-218 (BD Biosciences)

(16) Insulin-like Growth Factor Binding Protein 3 Increases Mouse Preimplantation Embryo Cleavage Rate by Activation of IGF1R and EGFR Independent of IGF1 SignallingCellsNovember 24, 2022Green CJ, Span M, Rayhanna MH, Perera M, Day ML.at a concentration of 100 μg/mL in sterile PBS. Human/mouse IGF1R neutralising antibody (IGF1R nAb; AF-305-NA; R&D Systems) was reconstituted at 0.2 mg/mL in PBS. Aliquots were prepared and stored at −80 °C. Erlotinib hydrochloride

(17) CircRNA hsa_circ_0002577 accelerates endometrial cancer progression through activating IGF1R/PI3K/Akt pathwayJournal of experimental & clinical cancer research : CRAugust 26, 2020Wang Y, Yin L, Sun X.

(18) IGF1R is an entry receptor for respiratory syncytial virusNatureJuly 1, 2020Griffiths CD, Bilawchuk LM, McDonough JE, Jamieson KC, Elawar F, Cen Y, Duan W, Lin C, Song H, Casanova JL, et al.

(19) Protection of insulin‑like growth factor 1 on experimental peripheral neuropathy in diabetic miceMolecular medicine reportsNovember 1, 2018Wang H, Zhang H, Cao F, Lu J, Tang J, Li H, Zhang Y, Feng B, Tang Z.

(20) Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugsCancer cell internationalJanuary 1, 2018Haas B, Klinger V, Keksel C, Bonigut V, Kiefer D, Caspers J, Walther J, Wos-Maganga M, Weickhardt S, Röhn G, et al.the following antibodies were used as previously described [53, 54]. Anti-EGF-R (AF-231), anti-IGF-R (AF-305-NA), anti-PDGF-Rβ (AF-385) combined with donkey anti-goat IgG-HRP (HAF 109; all R&D systems). Anti-MRP-2

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IGF-I R/IGF1R Antibody

IGF-I R/IGF1R Antibody

IGF-I R/IGF1R Antibody

IGF-I R/IGF1R Antibody

IGF-I R/IGF1R Antibody

IGF-I R/IGF1R Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (36)

Reviews

IGF-I R/IGF1R Antibody from R&D Systems, a Bio-Techne Brand

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