Cathepsin C/DPPI Antibody AF1034 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemCathepsin C/DPPI Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $489.00Supplier Page View Company Product Page
Catalog NumberAF1034
NCBI Gene AliasesDPPI, CatC, PLS, PALS, JP, JPD, HMS, PDON1, DPP1, DPP-I, CPPI
ApplicationsImmunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Simple Western,Immunocytochemistry
Quantity100 ug (also 25 ug)
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ReactivityHuman,Mouse,Rat,Transgenic Mouse
TargetCathepsin C/DPPI
HostGoat
IsotypeIgG
Conjugate/TagUnconjugated
NCBI Full Gene Namecathepsin C
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse Cathepsin C/DPPI, Asp25-Leu462, Accession # P97821
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse Cathepsin C/DPPI in direct ELISAs and Western blots. In direct ELISAs, approximately 15% cross-reactivity with recombinant human (rh) Cathepsin C is observed and less than 1% cross-reactivity with recombinant mouse (rm) Cathepsin A, rmCathepsin B, rmCathepsin D, rmCathepsin H, and rmCathepsin X/Z/P is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Single Cell Sequencing Identifies Distinct Cellular Alterations in Impaired Aged and Diabetic WoundsAging cellDecember 1, 2025Rojas Cortez L, Afzali H, Lyu Z, Liu M, Rojas A, Yang J, Gonzalez MV, Armingol E, Troka M, Maracaja-Coutinho V, et al.

(2) Increased expression of cathepsin C in airway epithelia exacerbates airway remodeling in asthmaJCI insightNovember 22, 2024Yuan L, Qin Q, Yao Y, Chen L, Liu H, Du X, Ji M, Wu X, Wang W, Qin Q, et al.

(3) Targeting cathepsin C ameliorates murine acetaminophen-induced liver injuryTheranosticsMay 13, 2024Jessica Raith, Malte Bachmann, Sina Gonther, Hendrik Stülb, Ali A. Aghdassi, Christine T. N. Pham, Heiko Mühland immunoblotting was performed (50 µg of total protein per lane) using a goat polyclonal antibody (R&D Systems, #AF1034). In accord with previous data 26, murine CtsC protein produced specific staining at 25 kD. Statistical

(4) Inflammatory Serine Proteases Play a Critical Role in the Early Pathogenesis of Diabetic CardiomyopathyCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacologyJanuary 1, 2019Kolpakov MA, Sikder K, Sarkar A, Chaki S, Shukla SK, Guo X, Qi Z, Barbery C, Sabri A, Rafiq K.

(5) The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease modelGliaJune 1, 2017Shimizu T, Wisessmith W, Li J, Abe M, Sakimura K, Chetsawang B, Sahara Y, Tohyama K, Tanaka KF, Ikenaka K.

(6) Neutrophils and neutrophil serine proteases are increased in the spleens of estrogen-treated C57BL/6 mice and several strains of spontaneous lupus-prone micePloS oneJanuary 1, 2017Dai R, Cowan C, Heid B, Khan D, Liang Z, Pham CT, Ahmed SA.

(7) Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cellsMolecular cancerFebruary 15, 2015Kern U, Wischnewski V, Biniossek ML, Schilling O, Reinheckel T.antibody dilutions: primary: actin: MP 69100 (1: 2000); Ctsb: R&D systems AF965 (1:250); Ctsc R&D Systems AF1034 (1:50); Ctsd R&D systems AF1029 (1:200); Ctsl: R&D systems AF1515 (1:500); Ctsh R&D Systems AF 1013

(8) Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancerPloS oneJanuary 1, 2015Brindle NR, Joyce JA, Rostker F, Lawlor ER, Swigart-Brown L, Evan G, Hanahan D, Shchors K.R&D), and anti-cystein cathepsins antibodies—Cathepsin B (AF965), Cathepsin S (AF1183), Cathepsin C (AF1034), and Cathepsin L (AF1515) (all from R&D Systems). All were applied in blocking buffer (2.5% BSA, 5%

(9) Increased immunoreactivity of cathepsins in the rat esophagus under chronic acid reflux esophagitisThe journal of histochemistry and cytochemistry : official journal of the Histochemistry SocietySeptember 1, 2014Suyama M, Koike M, Asaoka D, Mori H, Oguro M, Ueno T, Nagahara A, Watanabe S, Uchiyama Y.CS or CX with lamp1 and CD68, the sections were incubated with goat anti-CC, -CF, -CX (AF1033 AF2544 or AF1034, respectively, R&D Systems) (1:100) or goat anti-CS (sc6505; Santa Cruz Biotechnology, Dallas, TX) (1:100)

(10) The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine inductionFASEB journal : official publication of the Federation of American Societies for Experimental BiologyJanuary 1, 2014Müller S, Faulhaber A, Sieber C, Pfeifer D, Hochberg T, Gansz M, Deshmukh SD, Dauth S, Brix K, Saftig P, et al.

(11) Increased invasiveness of MMP-9-deficient tumors in two mouse models of neuroendocrine tumorigenesisOncogeneJanuary 24, 2013Shchors K, Nozawa H, Xu J, Rostker F, Swigart-Brown L, Evan G, Hanahan D.membranes. Primary antibodies used were as follows: cathepsin B (AF965), cathepsin S (AF1183), cathepsin C (AF1034) (R&D Systems), neutrophil elastase (sc-9521, Santa Cruz, Santa Cruz, CA, USA), anti-bactin (A2228,

(12) Up-regulation of microglial cathepsin C expression and activity in lipopolysaccharide-induced neuroinflammationJournal of neuroinflammationMay 20, 2012Fan K, Wu X, Fan B, Li N, Lin Y, Yao Y, Ma J.

(13) Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancerGenes & developmentDecember 1, 2011Shree T, Olson OC, Elie BT, Kester JC, Garfall AL, Simpson K, Bell-McGuinn KM, Zabor EC, Brogi E, Joyce JA.

(14) Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsinBloodSeptember 22, 2011Zhang B, Zheng C, Zhu M, Tao J, Vasievich MP, Baines A, Kim J, Schekman R, Kaufman RJ, Ginsburg D.

(15) A role for serglycin proteoglycan in mast cell apoptosis induced by a secretory granule-mediated pathwayThe Journal of biological chemistryFebruary 18, 2011Melo FR, Waern I, Rönnberg E, Åbrink M, Lee DM, Schlenner SM, Feyerabend TB, Rodewald HR, Turk B, Wernersson S, et al.

(16) Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in micePloS oneJanuary 1, 2011Bühling F, Kouadio M, Chwieralski CE, Kern U, Hohlfeld JM, Klemm N, Friedrichs N, Roth W, Deussing JM, Peters C, et al.membranes were probed with a 1∶500 dilution of anti-mouse Ctsc or anti-mouse Ctse antibody (R&D Systems AF1034, AF1130), or anti-SP-B antibody (Millipore ABS21) and HRP conjugated anti-goat (Sigma A5420) or anti-rabbit

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Cathepsin C/DPPI Antibody

Cathepsin C/DPPI Antibody

Cathepsin C/DPPI Antibody

Cathepsin C/DPPI Antibody

Cathepsin C/DPPI Antibody

Cathepsin C/DPPI Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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Cathepsin C/DPPI Antibody from R&D Systems, a Bio-Techne Brand

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