gp130 Antibody AF-228-NA from R&D Systems, a Bio-Techne Brand

Product Specs
Itemgp130 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF-228-NA
NCBI Gene AliasesHIES4, CD130, CDW130, sGP130, IL-6RB, GP130, IMD94, HIES4B, HIES4A, STWS2
ApplicationsCo-Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Proximity Ligation Assay,Neutralization,Immunocytochemistry
IsotypeIgG
ReactivityHuman,Primate
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
Targetgp130
HostGoat
Conjugate/TagUnconjugated
Quantity100 ug (also 25 ug)
NCBI Full Gene Nameinterleukin 6 cytokine family signal transducer
ClonalityPolyclonal
ImmunogenS. frugiperda insect ovarian cell line Sf 21-derived recombinant human gp130, Leu24-Glu619 (Glu619Asp), Accession # P40189
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects human gp130 in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant rat gp130, recombinant mouse gp130, recombinant human (rh) IL-1 sRI, rhIL-1 sRII, rhIL-2 sRß, rhIL-2 sR gamma, rhIL-4 sR, and rhIL-6 sR is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Prostatic fibroblast reprogramming by Interleukin-30 activates prostate cancer metastasis programsMol BiomedJune 24, 2026Stefania Livia Ciummo, Carlo Sorrentino, Simona Marchetti, Cristiano Fieni, Paola Lanuti, Emma Di Carlo(2.5 µg/ml; R&D Systems, Cat. #MAB227, RRID:AB_2127908) and anti-gp130 (2.5 µg/ml; R&D Systems, Cat. #AF-228-NA, RRID:AB_354411) antibodies. Neutralizing antibodies were applied for 1 h at 37 °C before IL30 stimulation

(2) The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130Molecular neurodegenerationFebruary 21, 2023Müller SA, Shmueli MD, Feng X, Tüshaus J, Schumacher N, Clark R, Smith BE, Chi A, Rose-John S, Kennedy ME, et al.

(3) Empagliflozin Reverses Oxidized LDL-Induced RECK Suppression, Cardiotrophin-1 Expression, MMP Activation, and Human Aortic Smooth Muscle Cell Proliferation and MigrationMediators of inflammationJanuary 1, 2023Chandrasekar B, Mummidi S, DeMarco VG, Higashi Y.and polyclonal antihuman gp130 (used in neutralization (2.5 µg/ml) and Western blotting (1 µg/ml)), #AF-228-NA, R&D Systems, Minneapolis, MN), control IgG (normal goat IgG control, #AF-108-C, R&D Systems). Secreted

(4) Effects of Empagliflozin on Intermittent Hypoxia-Induced TRAF3IP2-Dependent Human Aortic Smooth Muscle Cell ProliferationMedical Research ArchivesOctober 31, 2022Ryan Dashek, Yusuke Higashi, Nitin A. Das, Jacob J. Russell, Luis A. Martinez-Lemus, R. Scott Rector, Bysani Chandrasekar(#ab90347, abcam), HIF-1α (#ab179483, abcam), IL-6 (#ab233706, abcam), gp130 (#ab217671, abcam), IL-6R (#AF-228-NA, R & D Systems), SGLT2 (#sc-393350, Santa Cruz Biotechnology, Inc., Dallas, TX; SCB) and MyD88 (#sc-74532,

(5) CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activityJCI insightMay 10, 2021Filppu P, Tanjore Ramanathan J, Granberg KJ, Gucciardo E, Haapasalo H, Lehti K, Nykter M, Le Joncour V, Laakkonen P.

(6) The pro- and anti-tumor roles of mesenchymal stem cells toward BRCA1-IRIS-overexpressing TNBC cellsBreast cancer research : BCRApril 24, 2019Ryan D, Paul BT, Koziol J, ElShamy WM.(sc-20675), and goat polyclonal anti-EP4 (16022) were from Santa Cruz Biotech. Goat polyclonal anti-gp130 (AF-228-NA) and mouse monoclonal anti-STAT3 (MAB1799) were from R&D Systems. Rabbit polyclonal anti-JAK2 (07-606)

(7) Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumorsMolecular cancer research : MCRDecember 1, 2014Anderson JL, Titz B, Akiyama R, Komisopoulou E, Park A, Tap WD, Graeber TG, Denny CT.

(8) NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastomaPloS oneJanuary 1, 2013McFarland BC, Hong SW, Rajbhandari R, Twitty GB Jr, Gray GK, Yu H, Benveniste EN, Nozell SE.

(9) Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancerNature geneticsJuly 1, 2012Zhang Z, Lee JC, Lin L, Olivas V, Au V, LaFramboise T, Abdel-Rahman M, Wang X, Levine AD, Rho JK, et al.

(10) Disturbances in the LIF pathway in the endometrium among women with unexplained infertilityFertility and sterilityJune 1, 2009Aghajanova L, Altmäe S, Bjuresten K, Hovatta O, Landgren BM, Stavreus-Evers A.

(11) Expression of leukemia inhibitory factor and its receptors is increased during differentiation of human embryonic stem cellsFertility and sterilityOctober 1, 2006Aghajanova L, Skottman H, Strömberg AM, Inzunza J, Lahesmaa R, Hovatta O.

(12) Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progressionCancer researchOctober 1, 2005Queen MM, Ryan RE, Holzer RG, Keller-Peck CR, Jorcyk CL.

(13) The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signalingFEBS lettersAugust 15, 2005He W, Gong K, Smith DK, Ip NY.

(14) Alterations in Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling in patients with end-stage dilated cardiomyopathyCirculationFebruary 18, 2003Podewski EK, Hilfiker-Kleiner D, Hilfiker A, Morawietz H, Lichtenberg A, Wollert KC, Drexler H.

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gp130 Antibody

gp130 Antibody

gp130 Antibody

gp130 Antibody

gp130 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (14)

Reviews

gp130 Antibody from R&D Systems, a Bio-Techne Brand

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