Phospho-SAPK/JNK (Thr183/Tyr185) (98F2) Rabbit mAb 4671S from Cell Signaling Technology

Product Specs
ItemPhospho-SAPK/JNK (Thr183/Tyr185) (98F2) Rabbit mAb
CompanyCell Signaling Technology
Price $401.00 Inquire
Catalog Number4671S
Quantity200 µl
ApplicationsW
ReactivityH, M, R, Hm
TargetSAPK/JNK1 (Thr183/Tyr185) phosphate
HostRabbit
NCBI Gene AliasesJNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c
ClonalityMonoclonal
NCBI Full Gene Namemitogen-activated protein kinase 8
Research AreaMAP Kinase Signaling
IsotypeIgG
Clone98F2
ModificationsJNK SAPK/JNK1 (Thr183/Tyr185) phosphate
Molecular Weight46, 54

Questions and Answers

Can this antibody be used to study JNK activation in the context of liver diseases?

Yes, the Phospho-SAPK/JNK (Thr183/Tyr185) Rabbit mAb has been utilized in studies investigating JNK activation in liver diseases. For instance, it was shown that JNK inhibitors blocked HCV-induced ER stress and TGF-β1 expression, indicating the role of JNK in liver fibrogenesis during HCV infection ().

Is this antibody effective for detecting JNK activation in T cell studies?

The antibody has been effectively used in T cell studies, where it was reported that Glossogyne tenuifolia extract inhibited T cell activation by suppressing JNK phosphorylation, demonstrating its relevance in modulating immune responses ().

What species can this antibody be used on for Western Blot applications?

The Phospho-SAPK/JNK antibody is reactive with multiple species, including human, mouse, hamster, and rat, making it versatile for various experimental models in Western Blot applications.

Are there any specific experimental conditions or treatments where this antibody has been cited?

Yes, the antibody has been cited in studies examining the effects of various treatments on JNK activation, such as in the context of oxidative stress and apoptosis in liver cancer cells, where JNK activation was linked to therapeutic responses ().

Cell Signaling Technology

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Phone: 978-867-2388
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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Tramadol induced hypoxia signaling and paraptosis-like cell death in breast cancer cells via HIF-1α and ATF4 dependent pathwaysRedox ReportDecember 31, 2026Zih-Syuan Wu, Shih-Ming Huang, Yi-Hsuan HuangERK (catalog no.: #4695), p-p38 (catalog no.: #9211), p-38 (catalog no.: #9212), p-JNK (catalog no.: #4671), and JNK (catalog no.: #67096) were obtained from Cell Signaling Technology (Danvers, MA, USA). Immunofluorescence microscopy

(2) Rhodomyrtus tomentosa fruit ameliorates LPS induced depression-like behaviors in mice by attenuating hippocampal neuroinflammation via inhibiting the TLR4/MyD88/MAPK/NF-κB/NLRP3 signaling pathwayFrontiers in NutritionApril 23, 2026Jingxi Zhang, Jinyuan Liang, Yan Xu, Jingyu Sun, Mengyue Zhang, Zhiyou Yang, Leigang Jin, Shaohong Chen, Yun-Tao Zhao, Chuanyin HuUSA)",66535 Anti-PSD95,"Cell Signaling Technology (MA, USA)",3450 Anti-P-JNK,"Cell Signaling Technology (MA, USA)",4671 Anti-JNK,"Cell Signaling Technology (MA, USA)",9252 Anti-P-p38,"Cell Signaling Technology (MA, USA)",4511 Anti-p38,"Cell Signaling Technology

(3) PP4 modulates macrophage-neutrophil crosstalk to restrict CCL5 -driven NETosis in sepsisRedox BiologyApril 1, 2026Feng-Ming Yang, Shih-Chang Hsu, Yu-Chih Wu, Ching-Lu Chen, Tse-Hua Tan, Szu-Yi Chou, Hui-Ming Chang, Edward T.H. YehMAPK (#9211, Cell Signaling), mouse anti-p38 MAPK (#9212, Cell Signaling), mouse anti-phospho-JNK (#4671, Cell Signaling), mouse anti-JNK (#9252, Cell Signaling), anti-phospho-TBK1 (#5483, Cell Signaling),

(4) Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood DisorderAdvanced ScienceMarch 1, 2026Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, et al.(Cat# A1112) and Trim31 (Cat# A10639) were from Abclonal. Antibodies against phospho‐JNK (P‐JNK, Cat# 4671) at Thr183/Tyr185 and LC3B (Cat# 2775) were from Cell Signaling Technology. Antibodies against PSD‐95

(5) miR-221/222 Facilitate Pituitary Adenoma Progression Via PHACTR4 DownregulationHum MutatFebruary 5, 2026Wenjing Dong, Shiju Yan, Lingyun Song, Wei Wang, Di Sun, Ping Pang, Guoqing Yang, Weijun Gu, Sujit Nair#4695S, CST), Caspase3 (1:1000, #4370S, CST), E‐cadherin (1:1000, #9252S, CST), and N‐cadherin (1:1000, #4671S, CST), respectively, overnight at 4°C. Membranes were incubated with secondary antibodies for 2 h at

(6) Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven InflammationAdvanced ScienceJanuary 30, 2026Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, et al.p44/42 MAPK (Erk1/2) antibody (Cat: 4668), Phospho‐p44/42 MAPK (Erk1/2) (Thr202/Tyr204) antibody (Cat: 4671), SAPK/JNK antibody (Cat: 9252), phospho‐SAPK/JNK (Thr183/Tyr185) antibody (Cat: 9251), Toll‐like Receptor 2 antibody

(7) Dexmedetomidine alleviates sepsis-associated acute kidney injury by inhibiting renal tubular ferroptosis via JNK/MAPK–LCN2 pathwayEuropean Journal of Medical ResearchJanuary 26, 2026Boyang Liu, Shengxiang Ao, Li Luo, Lin Qiao, Tianyin Kuang, Hongyan Xiao, Jing Zhou, Shuangqin Yin, Huaping Liang, Fen Li, et al.ab175186, 1:4000), Anti-GPX4 (CST, #52455, 1:1000), Anti-JNK (CST, #9252, 1:1000), Anti-p-JNK (CST, #4671, 1:1000), Anti-ERK (Proteintech, 11257–1-AP, 1:5000), Anti-p-ERK (Proteintech, 28733–1-AP, 1:3000),

(8) Activation of Cannabinoid Receptor 1 Enhances Wound Healing by Promoting the Proliferative PhaseInternational Journal of Molecular SciencesJanuary 23, 2026Hui Song Cui, Ya Xin Zheng, Yoon Soo Cho, Yeon Gyun Jung, In Suk Kwak, Yu Mi Ro, So Young Joo, June-Bum Kim, Cheong Hoon Seo(4696S) Phospho-AKT,Rabbit,1:1000,Cell Signaling Technology (4060S) AKT,Rabbit,1:1000,Cell Signaling Technology (4671S) Primary antibodies used in Western blot analysis.

(9) Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1J Exp MedJanuary 5, 2026Ran Liu, Gengqiao Wang, Zhengting Jiang, Tianhao Zou, Chuanzheng Wang, Weimin Wang, Mao Cai, Shuhua Zhang, Guoliang Wang, Huan Cao, et al.Cell Signaling Technology), p-MLKL (37333; Cell Signaling Technology), MLKL (ab243142; Abcam), p-JNK (4671; Cell Signaling Technology), JNK (24164-1-AP; Proteintech), p-ERK (4370; Cell Signaling Technology),

(10) Ginsenoside Rh2 Suppresses the Fanconi Anemia Pathway by Inhibiting NF-κB-Mediated FANCL Transcription in Bladder CancerDose ResponseDecember 18, 2025Chen Li, Guanglin Lv, Zhuang Xiong, Zhenfan Wang9275), JNK (Cell Signaling Technology, Cat. 9252), p-JNK Thr183/Tyr185 (Cell Signaling Technology, Cat. 4671), STAT3 (Cell Signaling Technology, Cat. 4904), and p-STAT3 Tyr705 (Cell Signaling Technology, Cat.

(11) Targeting c-Jun orchestrates heat stroke-induced myocardial injury and reveals its biomarker potentialFrontiers in ImmunologyNovember 12, 2025Yunfei Xiang, Rui Huang, Xuemei Jiang, Qingsong Chen, Can Luo, Hongxia Wang, Junyu Jiang, Jia Xie, Guangbin Huang, Menglong Liu, et al.c-Jun (9165T, Cell Signaling Technology, USA), JNK (4668T, Cell Signaling Technology, USA), P-JNK (4671T, Cell Signaling Technology, USA), p38 MAPK (8690T, Cell Signaling Technology, USA), P-p38 MAPK (9211S,

(12) Sialylation Inhibition Impairs Migration and Promotes Adhesion of GBM CellsInternational Journal of Molecular SciencesNovember 3, 2025Deborah Gargano, Mariangela Calvitto, Antonella Niro, Giuseppe Pepe, Noemi Martella, Alessia Tani, Paolo Rosa, Vittorio Maglione, Giovanni Musci, Antimo Cutone, et al.Cell Signaling Technology, CS-2108), anti-phospho SAPK/JNK (Thr183/Tyr185, 1:1000, Cell Signaling Technology, CS-4671) and anti-SAPK/JNK (1:1000, Cell Signaling Technology, CS-9252). 4.11. Statistical Analysis All the

(13) Promising effects of astaxanthin on pain-related behaviors and morphine tolerance in a mouse model of neuropathic pain: Possible involvement of Nrf2 and the NMDA receptor subunit NR2BNeurotherapeuticsOctober 25, 2025Katarzyna Ciapała, Katarzyna Pawlik, Agata Ciechanowska, Wioletta Makuch, Joanna Mikaanti-pp38 (1:1000, 4631; Cell Signaling), anti-pERK1/2 (1:1000, 4370; Cell Signaling), anti-pJNK (1:1000, 4671; Cell Signaling), anti-pNFκB (1:1000, sc-33039; Santa Cruz, Dallas, USA), anti-Sod1 (1:1000, 37 385;

(14) Allosteric SHP2 inhibitors suppress lung cancer cell migration by inhibiting non-canonical activation of EphA2 via the ERK-RSK signaling pathwaySci RepOctober 22, 2025Khanh Nguyen, Yue Zhou, Satoru Yokoyama, So-Ichiro Sasaki, Seiji Yano, Ryuji Hayashi, Keiichi Koizumi, Yoshihiro Hayakawa, Hiroaki Sakuraiphospho-ERK (Thr-202/Tyr-204; #9101), phospho-p38 (Thr-180/Tyr-182; #4511S), phospho-JNK (Thr-183/Tyr-185; #4671), phospho-p65 (Ser-536; #3033), phospho-SHP2 (Tyr-542; #15543), and phospho-RSK1 (Ser-380; #11989) were

(15) Effects of Slit2 on hypertrophic scar formation: an in vitro study in fibroblastsScientific ReportsSeptember 26, 2025Hui Song Cui, Yoon Soo Cho, So Young Joo, Ya Xin Zheng, Yu Mi Ro, Kibum Jeon, Cheong Hoon Seo(4696S) Phospho-AKT,Rabbit,1:1000,Cell signaling technology (4060S) AKT,Rabbit,1:1000,Cell signaling technology (4671S) Primary antibodies used in western blot analysis.

(16) NOSH-aspirin (NBS-1120) attenuates motor defects and dopaminergic neuron degeneration in a rat model of Parkinson's diseaseEuropean Journal of PharmacologySeptember 5, 2025Bita Firouzan, Rasoul Ghasemi, Michael T. Tetteh, John B. Matson, Khosrow Kashfiantibodies including β-actin (4970), the phosphorylated form of antibodies including P38 (9211), JNK (4671), ERK (4377), and anti-rabbit horseradish peroxidase (HRP) secondary antibody (7074) were from Cell Signaling Technology

(17) Immunomodulatory Effects of Traditional Korean Gochujang in Rats Immunosuppressed with CyclophosphamideInternational Journal of Molecular SciencesAugust 27, 2025Hak Yong Lee, Young Mi Park, Dong Yeop Shin, Hai Min Hwang, Sung Hak Chun, Sang Jin Lim, Hee-Jong Yang, Gwang Su Ha, Myeong Seon Ryu, Ji-Won Seo, et al.antibodies, including Phospho-Erk (#9101), Erk (#9102), Phospho-p38 (#9216), p38 (#9212), Phospho-JNK (#4671), JNK (#9252), Phospho-NFκB (#3033), nuclear factor kappa B (NF-κB; #8242), and β-actin (#4857), which

(18) CARM1-mediated MAP2K4 methylation potentiates the oncogenic functions of MAP2K4 and constitutes a targetable dependency in triple-negative breast cancerCancer ResAugust 15, 2025Eui-Jun Kim, Yidan Wang, Yu-Lin Chen, Min Ma, Peng Liu, Megan S. Bacabac, Jingjing Zhou, Christopher J Fry, Jordan R. Hoffman, Menggang Yu, et al.(Cell Signaling Technology Cat# 4514, RRID:AB_2140946), anti-p-JNK (98F2) (Cell Signaling Technology Cat# 4671, RRID:AB_331338), anti-JNK (Cell Signaling Technology Cat# 9252, RRID:AB_2250373), anti-p-ERK (D1H6G)

(19) CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast CancerCancer ResearchAugust 15, 2025Eui-Jun Kim, Yidan Wang, Yu-Lin Chen, Min Ma, Peng Liu, Megan S. Bacabac, Jingjing Zhou, Christopher J. Fry, Jordan R. Hoffman, Menggang Yu, et al.(Cell Signaling Technology Cat# 4514, RRID:AB_2140946), anti-p-JNK (98F2) (Cell Signaling Technology Cat# 4671, RRID:AB_331338), anti-JNK (Cell Signaling Technology Cat# 9252, RRID:AB_2250373), anti-p-ERK (D1H6G)

(20) Methionine Restriction Attenuates Scar Formation in Fibroblasts Derived from Patients with Post-Burn Hypertrophic ScarInt J Mol SciJune 19, 2025Hui Song Cui, Ya Xin Zheng, Yoon Soo Cho, Yu Mi Ro, In Suk Kwak, So Young Joo, Cheong Hoon Seo(8690S) Phospho-AKT,Rabbit,1:1000,Cell Signaling Technology (4060S) AKT,Rabbit,1:1000,Cell Signaling Technology (4671S) Phospho-mTOR,Rabbit,1:1000,Cusabio Technology (CSB-PA000576) mTOR,Rabbit,1:1000,Cusabio Technology

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2/15/2022Perfect P-JNK Antibody for Western Blot Kumar SubramaniIn our experiment, I tested this antibody for the time-course effect of JNK protein levels in HASMC cells.

Phospho-SAPK/JNK (Thr183/Tyr185) (98F2) Rabbit mAb

Phospho-SAPK/JNK (Thr183/Tyr185) (98F2) Rabbit mAb from Cell Signaling Technology

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Questions and Answers

Cell Signaling Technology

Citations (210)

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Phospho-SAPK/JNK (Thr183/Tyr185) (98F2) Rabbit mAb from Cell Signaling Technology

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