Fig 1: Computer-based determination of labyrinthin and ASPH cellular localization. Depiction of labyrinthin (left) localized on the extracellular side as predicted by the Protter program. A TM domain has been reported by some programs [43]; Protter found TM that was indeterminant but did possess a signal peptide (amino acids 1–17; coded in red). By comparison, no signal peptide was found for ASPH, but a transmembrane domain (amino acids 54–74) was identified for intracellular organelle-associated ASPH (right).