beta-Arrestin 1/2 (D24H9) Rabbit mAb 4674S from Cell Signaling Technology

Product Specs
Itembeta-Arrestin 1/2 (D24H9) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number4674S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R, Mk
HostRabbit
ClonalityMonoclonal
TargetArrestin, beta1;Arrestin, beta2
NCBI Full Gene Namearrestin beta 2, arrestin beta 1
NCBI Gene AliasesARR1, BARR2, ARB2, ARB1, ARR2
Research AreaMAP Kinase Signaling
IsotypeIgG
CloneD24H9
Molecular Weight50

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Cell Signaling Technology

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Danvers, Massachusetts 01923

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Phone: 877-616-CELL
Phone: 978-867-2388
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Website: http://www.cellsignal.com/

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(1) Cytoplasmic tail diversity determines the effector bias of the adhesion GPCR ADGRL2Cell Chem BiolMarch 19, 2026Krassimira A. Garbett, Chen Zheng, Julia Drube, Carsten Hoffmann, Vsevolod V. Gurevich, Richard C. SandoProteintech 67580–1-Ig, arrestin-3 Proteintech 10171–1-AP, and arrestin-2/3 Cell Signaling Technology #4674). Plasmids. All aGPCR overexpression cDNAs used were encoded in the pEB Multi-Neo vector (Wako Chemicals,

(2) Conformational biosensors delineate endosomal G protein regulation by GPCRsNature CommunicationsFebruary 18, 2026Brian Wysolmerski, Nicole M. Fisher, Andrew N. Dates, Asuka Inoue, Emily E. Blythe, Mark von Zastrowbuffer (LI-COR 927-60001)), a monoclonal rabbit βARR1/2 antibody (D24H9, Cell Signaling Technology 4674, 1:1000, blocked in LI-COR Intercept (TBS) blocking buffer), or a monoclonal mouse anti-Flag M1 antibody

(3) Designing allosteric modulators to change GPCR G protein subtype selectivityNatureOctober 22, 2025Madelyn N. Moore, Kelsey L. Person, Valeria L. Robleto, Abigail R. Alwin, Campbell L. Krusemark, Noah Foster, Caroline Ray, Asuka Inoue, Michael R. Jackson, Michael J. Sheedlo, et al.membranes were incubated overnight at 4 °C with rabbit anti-β-arrestin 1/2 (Cell Signaling Technology, 4674, RRID: AB_10547883) in 50% blocking buffer and 50% TBST at a 1:1,000 dilution. Membranes were washed

(4) A genetically encoded nanobody sensor reveals conformational diversity in β-arrestins orchestrated by distinct seven transmembrane receptorsProceedings of the National Academy of SciencesSeptember 16, 2025Parishmita Sarma, Vendula Nagy Marková, Annu Dalal, Sudha Mishra, Nashrah Zaidi, Divyanshu Tiwari, Manish K. Yadav, Nabarun Roy, Gargi Mahajan, Paul Miclea, et al.Afterward, βarr1/2, Ib32, and the receptors were probed using βarr1/2 antibody (1:5000, CST, Cat. no. 4674), monoclonal anti-rabbit IgG peroxidase coupled antibody, anti-HA antibody (1:5000; Santa-Cruz; cat.

(5) Cytoplasmic tail composition modulates the G protein and arrestin-3 signaling bias of the adhesion GPCR LPHN2bioRxivJuly 6, 2025Krassimira Garbett, Chen Zheng, Julia Drube, Carsten Hoffmann, Vsevolod V. Gurevich, Richard C. SandoProteintech 67580–1-Ig, arrestin-3 Proteintech 10171–1-AP, and arrestin-2/3 Cell Signaling Technology #4674). Plasmids. All aGPCR overexpression cDNAs used were encoded in the pEB Multi-Neo vector (Wako Chemicals,

(6) Conformational biosensors delineate endosomal G protein regulation by GPCRsBIORXIVMay 13, 2025Brian Wysolmerski, Emily E. Blythe, Mark von Zastrowblocking buffer (Licor 927–60001), a monoclonal rabbit βARR1/2 antibody (D24H9, Cell Signaling Technology 4674, 1:1000, blocked in LICOR Intercept (TBS) blocking buffer), or a monoclonal mouse anti-Flag M1 antibody

(7) WTX-L/β-arrestin2/LCN2 axis controls vulnerability to ferroptosis in gastric canceriScienceMarch 21, 2025Yangwei Xu, Xuexia Qian, Guixing Cai, Zhihao Lin, Weiye Huang, Chuangyuan Wang, Hongmei Wu, Yiqiong Zhang, Jingbo Sun, Qingling ZhangRRID: AB_11182611 LCN2,Abcam,Cat#ab63929; RRID: AB_1140965 β-arrestin2,Cell Signaling Technology,Cat#4674S WTX-WT,This paper,N/A WTX-L,This paper,N/A WTX-S,This paper,N/A P65,Cell Signaling Technology,Cat#8242;

(8) Receptor Determinants for β-Arrestin Functional Specificity at C-X-C Chemokine Receptor 5Molecular PharmacologyDecember 1, 2024Joseph M. Crecelius, Aaren R. Manz, Sara Benzow, Adriano Marchesefrom ThermoFisher (31985070). Antibodies against pERK1/2 (4370S), ERK1/2 (4695S), and β-arrestin1/2 (4674) were from Cell Signaling Technologies. Anti-FLAG M2-alkaline phosphatase-conjugated antibody was from

(9) Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogationiScienceJuly 19, 2024Kopsidas CA, Lowe CC, McDaniel DP, Zhou X, Feng Y.AB_331405 Gsk3β,Cell Signaling Technology,Cat# 12456; RRID: AB_2636978 β-Arrestin 1/2,Cell Signaling Technology,Cat# 4674; RRID: AB_10547883 pCREB,Cell Signaling Technology,Cat# 9196; RRID: AB_331275 Calbindin,ThermoFisher,Cat#

(10) Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposityNature MetabolismSeptember 14, 2023Wenwen Gao, Lei Liu, Eunna Huh, Florence Gbahou, Erika Cecon, Masaya Oshima, Ludivine Houzé, Panagiotis Katsonis, Alan Hegron, Zhiran Fan, et al.were carried out with primary antibodies against the Flag tag (F7425, Sigma-Aldrich) and β-arr1/2 (4674, Cell Signaling Technology). Immunoreactivity was revealed using a secondary antibody coupled to 680

(11) α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosisTranslational neurodegenerationAugust 25, 2023Wang P, Lan G, Xu B, Yu Z, Tian C, Lei X, Meissner WG, Feng T, Yang Y, Zhang J.anti-Lamp2 (199947, Abcam, 1:1000), anti-Alix (2171, Cell Signaling Technology, 1:1000), anti-GFAP (4674, Abcam, 1:1000), anti-α-syn (MJFR14, ab214033, Abcam, 1:100), and anti-α-syn (SYN211, ab206675, Abcam,

(12) SCAND1 Reverses Epithelial-to-Mesenchymal Transition (EMT) and Suppresses Prostate Cancer Growth and MigrationCellsDecember 10, 2022Takanori Eguchi, Eva Csizmadia, Hotaka Kawai, Mona Sheta, Kunihiro Yoshida, Thomas L. Prince, Barbara Wegiel, Stuart K. Calderwood#4370P), total ERK-1/2 (137F5, #4695), phosphorylated NF-κB p65 S536 (93H1, #3033S), total NF-κB p65 (#4674S) and HSP90β (#5087) were purchased from Cell Signaling Technologies (CST, Danvers, MA, USA). 2.7. Post-translational

(13) Carvedilol targets β-arrestins to rewire innate immunity and improve oncolytic adenoviral therapyCommunications BiologyDecember 1, 2022Joseph I. Hoare, Bleona Osmani, Emily A. O’Sullivan, Ashley Browne, Nicola Campbell, Stephen Metcalf, Francesco Nicolini, Jayeta Saxena, Sarah A. Martin, Michelle Lockleyphospho-ERK1/2: Cell Signalling 4370, 1:1000; ERK1/2: Cell Signalling 9102; ARRB1/2: Cell Signalling 4674S, 1:500; ARRB1: Cell Signalling 12697S, 1:500. NFκB reporter assay NFκB activity was measured using

(14) Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabodyNature communicationsAugust 8, 2022Baidya M, Chaturvedi M, Dwivedi-Agnihotri H, Ranjan A, Devost D, Namkung Y, Stepniewski TM, Pandey S, Baruah M, Panigrahi B, et al.SDS–polyacrylamide gel electrophoresis and probed using βarr antibody (dilution-1: 10000; CST; cat. no. 4674). After solubilization, 20 μl of lysate was set aside for confirming equal loading of βarr1 and ScFv.

(15) Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart FailureCirculation ResearchJuly 8, 2022Di Zhu, Zhen Zhang, Jianli Zhao, Demin Liu, Lu Gan, Wayne Bond Lau, Dina Xie, Zhijun Meng, Peng Yao, Jumpei Tsukuda, et al.y,sc-518030,1:500,,https://www.scbt.com/p/adipor1-antibody-d-9?productCanUrl=adipor1-antibody-d-9&_requestid=5867389 Anti-β-arrestin1/2 rabbit monoclonal antibody,Cell Signaling Technology,4674,1:1000,,https://www.cellsignal.com/product/productDetail.jsp?productId=4674 Anti-GFP rabbit polyclonal

(16) Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in miceJCI insightApril 22, 2022Swain SM, Romac JM, Vigna SR, Liddle RA.ab2413), rabbit anti–collagen type I antibody (Abcam, ab34710), or chicken anti-GFAP antibody (Abcam, 4674) for mouse PSCs or rabbit anti-GFAP (Cell Signaling Technology,12389) for human PSCs overnight at 2°C–8°C.

(17) BRET-Based Biosensors to Measure Agonist Efficacies in Histamine H1 Receptor-Mediated G Protein Activation, Signaling and Interactions with GRKs and β-ArrestinsInternational Journal of Molecular SciencesMarch 16, 2022Eléonore W. E. Verweij, Reggie Bosma, Meichun Gao, Jelle van den Bor, Betty Al Araaj, Sabrina M. de Munnik, Xiaoyuan Ma, Rob Leurs, Henry F. Vischer(CTZ-h), and NanoGlo® were purchased from Promega (Madison, WI, USA). Anti-β-arrestin1/2 clone D24H9 (#4674) and anti-STAT3 clone 79D7 (#4904) were purchased from Cell Signaling Technology (Danvers, MA, USA).

(18) Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptorsMolecular cellNovember 18, 2021Pandey S, Kumari P, Baidya M, Kise R, Cao Y, Dwivedi-Agnihotri H, Banerjee R, Li XX, Cui CS, Lee JD, et al.and βarr were probed by immunoblotting by using rabbit mAb anti-βarr antibody (1:5000, CST, Cat. no. 4674). The blot was stripped and then reprobed for FLAG-tagged receptor using anti-FLAG antibody (1:2000,

(19) Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activationScience SignalingOctober 5, 2021Alex D. White et al.nitrocellulose membrane. We used antibodies against HA (Covance, clone 16B12), and βarr-1/2 (Cell Signaling, 4674, clone D24H9). Immunoreactive bands were visualized with Luminata Forte (EMD Millipore) and autoradiography

(20) Recombinant CRAMP-producing Lactococcus lactis attenuates dextran sulfate sodium-induced colitis by colonic colonization and inhibiting p38/NF-κB signalingFood & Nutrition ResearchSeptember 28, 2021Jiahong Li, Shiwen Yu, Xiaohua Pan, Ming Zhang, Zhuwu Lv, Li-Long Pan, Jia Sun(#4511), p-Erk1/2 (#9101), p-NF-κBp65 (#3033), total-p38 (#8690), total-ERK (#4695), and total-NF-κB p65 (#4674) were used. Anti-rabbit secondary antibody was purchased from Thermo Fisher Scientific (31460, Waltham,

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8/31/2016ß-Arrestin 1/2 from Cell Signaling is a Good Antibody to Use ZHIGANG LUI tested beta arrestin protein expression level in HEK 293T cells. I tried the #4647 in CST. It works very well and I can get two bands in the expected size. I strongly recommend you guys to use the ... Read Review

beta-Arrestin 1/2 (D24H9) Rabbit mAb

beta-Arrestin 1/2 (D24H9) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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beta-Arrestin 1/2 (D24H9) Rabbit mAb from Cell Signaling Technology

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