MRP2/ABCC2 (R260) Antibody 4446S from Cell Signaling Technology

Product Specs
ItemMRP2/ABCC2 (R260) Antibody
CompanyCell Signaling Technology
Price $378.00 Inquire
Catalog Number4446S
Quantity100 µl
ApplicationsW, IP, IF-IC
ReactivityH
TargetMRP2
Molecular Weight> 200
HostRabbit
NCBI Gene AliasesABC30, CMOAT, DJS, MRP2, cMRP
NCBI Full Gene NameATP binding cassette subfamily C member 2
ClonalityPolyclonal
CloneR260
Research AreaMetabolism

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 LactylationAdvanced ScienceMarch 7, 2026Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhoutag (ab32, Abcam), Flag tag (MA1‐91878, Invitrogen), MDR1 (#13978, CST), MRP1 (#72202, CST), MRP2 (#4446, CST), LRP (ab27309, Abcam), TOP 1 (#79971, CST), TOP 2A (ab52934, Abcam), TYMS (#9045, CST), α‐tubulin

(2) Eplerenone, a mineralocorticoid receptor inhibitor, reduces cirrhosis associated changes of hepatocyte glucose and lipid metabolismCell communication and signaling : CCSDecember 20, 2024Mohib MM, Rabe S, Nolze A, Rooney M, Ain Q, Zipprich A, Gekle M, Schreier B.(1:2000, ab126285; Abcam); anti-PDK4 picoband (1:2000, PB9773, Boster Bio); anti-MRP2/ABCC2 (1:1000; #4446; Cell Signaling Technology); anti-Lipin 1 (1:1000; #5195; Cell Signaling Technology); anti-AMACR (1:2000;

(3) Downregulation of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase responseCommunications BiologyMay 16, 2024Charlotte Ehle, Aishwarya Iyer-Bierhoff, Yunchen Wu, Shaojun Xing, Michael Kiehntopf, Alexander S. Mosig, Maren Godmann, Thorsten Heinzel(1:200 HNF4A Abcam #ab92378; 1:250 p65 Santa-Cruz #sc-8008; 1:100 MRP2 Cell Signaling Technology, #4446; 1:50 ApoB Santa-Cruz #sc-13538) in incubation solution (0.1% (w/v) Saponin, 0.25% (w/v) BSA in PBS)

(4) An original donor-dependent spheroid system for the prediction of idiosyncratic drug-induced liver injury riskIn vitro modelsAugust 15, 2023Sara Cherradi, Nicolas Taulet, Hong Tuan DuongActin (ab8211, Abcam), ZO-1 (#61-7300, Life Technologies SAS, Courtaboeuf Cedex, France), and MRP2 (#4446, Cell Signaling) antibodies, were diluted in blocking buffer and incubated overnight at 4 °C. After

(5) SOX2 regulates paclitaxel resistance of A549 non‑small cell lung cancer cells via promoting transcription of ClC‑3Oncology ReportsSeptember 6, 2022Youwei Huang, Xiangyu Wang, Rendong Hu, Guopeng Pan, Xi LinCell Signaling Technology, Inc.), ATP binding cassette subfamily C member 2 (ABCC2; 1:1,000; cat. no. 4446; Cell Signaling Technology, Inc.), ATP binding cassette subfamily C member 10 (ABCC10; 1:1,000; cat.

(6) 4-Phenylbutyrate protects against rifampin-induced liver injury via regulating MRP2 ubiquitination through inhibiting endoplasmic reticulum stressBioengineeredFebruary 1, 2022Jing Chen, Hongbo Wu, Xudong Tang, Lei ChenTriton X-100 for 10 min, blocked with bovine serum albumin for 1 h, incubated with anti-MRP2 antibody (#4446, Cell Signaling Technology, MA, USA) overnight at 4°C and incubated with second antibody for 2 h at

(7) Essential Oils, Pituranthos chloranthus and Teucrium ramosissimum, Chemosensitize Resistant Human Uterine Sarcoma MES-SA/Dx5 Cells to Doxorubicin by Inducing Apoptosis and Targeting P-GlycoproteinNutrientsMay 19, 2021Lahmar A, Mathey A, Aires V, Elgueder D, Vejux A, Khlifi R, Sioud F, Chekir-Ghedira L, Delmas D.(#9662; 1:1000), Caspase 8 (#4790; 1:1000), Caspase 9 (#9502; 1:1000), BCRP (#42078; 1:1000), and MRP2 (#4446; 1:1000) were purchased from Cell Signaling Technology (Ozyme, Saint-Cyr-l’École, France). Anti-MRP1

(8) Upregulation of Chemoresistance by Mg²⁺ Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 CellsCellsMay 12, 2021Onuma S, Manabe A, Yoshino Y, Matsunaga T, Asai T, Ikari A.USA" ABCB1,GTX108354,39834,GeneTex,"Irvine, CA, USA" ABCC1,GTX116046,40135,GeneTex,"Irvine, CA, USA" ABCC2,4446S,1,Cell Signaling Technology,"Danvers, MA, USA" ABCG2,GTX100437,39471,GeneTex,"Irvine, CA, USA" Nrf2,16396-1-AP,10898000,ProteinTech,"Rosemont,

(9) The modulation study of multiple drug resistance in bladder cancer by curcumin and resveratrolOncology lettersDecember 1, 2019Cho CJ, Yang CW, Wu CL, Ho JY, Yu CP, Wu ST, Yu DS.bicinchoninic acid assay. Several proteins were analyzed, including: ABCB1 (cat. no. 13342), ABCC2 (cat. no. 4446) and ABCG2 (cat. no. 4477; all Cell Signaling Technology, Inc.) for drug efflux, deoxycytidine kinase

(10) Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cellsScientific reportsSeptember 24, 2019Maruhashi R, Eguchi H, Akizuki R, Hamada S, Furuta T, Matsunaga T, Endo S, Ichihara K, Ikari A."Cell Signaling Technology(Beverly, MA, USA)",ERK1/2,Rabbit,4695 "Cell Signaling Technology(Beverly, MA, USA)",ABCC2,Rabbit,4446 "Cell Signaling Technology(Beverly, MA, USA)",p-PDK1,Rabbit,S241 "Cell Signaling Technology(Beverly,

(11) Increase in resistance to anticancer drugs involves occludin in spheroid culture model of lung adenocarcinoma A549 cellsScientific reportsOctober 11, 2018Eguchi H, Akizuki R, Maruhashi R, Tsukimoto M, Furuta T, Matsunaga T, Endo S, Ikari A.Lot: 20), anti-p44/42 MAPK (ERK1/2, 4695, Lot: 1), anti-c-Fos (2250, Lot: 4), and anti-MRP2 (ABCC2, 4446, Lot: 1) polyclonal antibodies were from Cell Signaling Technology (Beverly, MA, USA). Goat anti-β-actin

(12) ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein armsPLoS geneticsMarch 1, 2018Cho KJ, Noh SH, Han SM, Choi WI, Kim HY, Yu S, Lee JS, Rim JH, Lee MG, Hildebrandt F, et al.

(13) Cyclocarya paliurus (Batal.) Ijinskaja Aqueous Extract (CPAE) Ameliorates Obesity by Improving Insulin Signaling in the Hypothalamus of a Metabolic Syndrome Rat ModelEvidence-Based Complementary and Alternative MedicineJune 8, 2017Guangyuan Xu et al.

(14) Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and ReproductionPLOS GeneticsJanuary 23, 2017Takashi Nakasuji et al.

(15) Omega-3 Fatty Acids Modulate Weibel-Palade Body Degranulation and Actin Cytoskeleton Rearrangement in PMA-Stimulated Human Umbilical Vein Endothelial CellsMarine DrugsNovember 8, 2013Corinna S. Bürgin-Maunder, Peter R. Brooks, Fraser D. Russellchamber. Cells were washed in 1 × PBS (3 × 5 min, 22 °C) and incubated with goat Mar. Drugs 2013, 11 4446 anti-mouse fluorochrome-conjugated secondary antibody (1:2000 in antibody diluting buffer, Cell Signaling,

(16) Multiple Protein Analysis of Formalin-fixed and Paraffin-embedded Tissue Samples with Reverse phase Protein ArraysMolecular & Cellular ProteomicsSeptember 1, 2013Maziar Assadi et al.

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MRP2/ABCC2 (R260) Antibody

MRP2/ABCC2 (R260) Antibody from Cell Signaling Technology

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Cell Signaling Technology

Citations (16)

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MRP2/ABCC2 (R260) Antibody from Cell Signaling Technology

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