Description
B6 DIO RD is a classic high-fat diet-induced obesity model. After 12–16 weeks of high-fat diet feeding, mice develop obesity, increased body fat, elevated leptin, hyperglycemia, hyperinsulinemia, impaired glucose tolerance, hyperlipidemia, elevated ALT, and hepatic steatosis, recapitulating obesity, insulin resistance, type 2 diabetes, hyperlipidemia, and MASLD. The model exhibits stable and reproducible phenotypes and has been validated with semaglutide and bimagrumab for efficacy studies