Chitin Resin from New England Biolabs

Product Specs
ItemChitin Resin
CompanyNew England Biolabs
Price $517.00 Inquire
Catalog NumberS6651L
Capacity2.0 mg maltose-binding protein
ApplicationsProteomics & Glycomics
Product TypeResins
ModeAffinity Purification
Temperature4 C
Matrixaffinity matrix
Quantity100 ml

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New England Biolabs

240 County Road

Ipswich, Massachusetts 1938

United States

Phone: 800-632-5227
800-632-7799
978-921-1350

Company Profile

Website: http://www.neb.com

(1) USP5 acts as a proteolytic switch to control SDE2 function via UBL-directed cleavageNature CommunicationsAugust 14, 2026Liam T. Hales, Paul M. Tammiste, Adam J. Walker, Rebecca Bryce, Andrew Sugden, Axel Knebel, Rachel Toth, Frédéric Lamoliatte, Marian Péteri, Oliwia Curry, et al.followed by filtration (0.22 µm syringe filter). Clarified lysate was incubated with chitin beads (#S6651, NEB) for 4 h at 4 °C on a rotatory platform. After incubation, beads were collected in a reusable column

(2) Genome-wide chromatin recording resolves dynamic cell state changesbioRxivJuly 19, 2026Yodai Takei, Jordan A. Lay, James M. Linton, Duncan M. Chadly, Yoshiki Ochiai, Ron Hadas, Andrew A. Perez, Mario R. Blanco, Paola Laurino, Mitchell Guttman, et al.loaded on an Econo-Column column (Bio-Rad Laboratories 7371022) filled with 10 mL of chitin resin (NEB S6651L). The column was washed with 50 mL of HEGX buffer, and then incubated with 15 mL of HEGX buffer supplemented

(3) Mechanism of negative supercoil relaxation by Topoisomerase IVNucleic Acids ResJune 27, 2026Soon Bahng, Rupesh Kumar, Kenneth J MarianspET-Impact-T4gp43(exo−) (Addgene plasmid 228202), a gift of Stephen Benkovic, and purified by chromatography on Chitin Resin (NEB) and phosphocellulose. Escherichia coli DNA ligase was from NEB. Reverse gyrase was the gift of

(4) Ubiquitin ligase ITCH regulates life cycle of SARS-CoV-2 virusElifeMay 29, 2026Qiwang Xiang, Camille Wouters, Peixi Chang, Yu-Ning Lu, Mingming Liu, Haocheng Wang, Haley Heine, Sunning Qian, Junqin Yang, Andrew Pekosz, et al.and mixed with Flag-antibody beads (Sigma, catalog number M8823), chitin resin (New England Biolabs, S6651), Strep-Tactin resin (Zymo Research, catalog number P2004-1-5), or S-protein agarose (Novagen, 69704).

(5) A scalable Tn5-based method for genome-wide DNA methylation profiling in development and diseaseNature CommunicationsMay 22, 2026Hanrong Hu, Nahuel Simonet, Ece Naz Bilgiç, Heather Murray, Regina Reimann, Markus Rechsteiner, Fides Zenk°C until further processing. The purification was performed on Chitin resin (New England Biolabs, #S6651S) as described38, with small modifications. The cells were lysed using a Fisherbrand sonicator for 2.5

(6) CoCUT&Tag maps linked chromatin states at single-molecule, single-cell resolutionbioRxivMay 5, 2026Wenjie Sun, Emma Baird, Harry J. Ashbaugh, Alexandria P. Eiken, Derek H. Janssensminutes. A chitin resin column was prepared in a 4oC cold room by gently inverting the resin (NEB #S6651) to resuspend and adding 2.5 mL resin to an Econo-Pac Chromatography Column (Bio-Rad #7321010). With

(7) Reprogramming of bacterial virulence by lysine acetylationNat CommunApril 27, 2026Ole Schmöker, Britta Girbardt, Sabrina Schulze, Gottfried J. Palm, Leona Berndt, Jens Hoppen, Nilüfer Kara, Xenia Schöps, Ruba Al-Abdulla, Klara Garz, et al.75 mM NaCl) on a chitin matrix gravity flow column (New England Biolabs, Frankfurt/Main DE, cat. no S6651L). After extensive washing with high salt washing buffer (20 mM HEPES, sodium acetate pH 6.5, 500 mM

(8) Chemically Defined Non-human Glycans Comprising Galactose-α1-3-Galactose (α-Gal) Epitopes Glycoengineered into the Fragment Antigen-Binding (Fab) Domain of Cetuximab Differentially Affect Human Anti-α-Gal Immunoglobulin E (IgE) BindingACS Pharmacology & Translational ScienceApril 10, 2026Grayson Hatfield, Lioudmila Tepliakova, Roger Y. TamDIN#02271249) was purchased from McKesson Canada. Chitin resin (50 μL slurry, New England Biolabs, catalog no. S6651S) was washed twice with 50 mM Tris buffer (pH 7.3), and EndoS-CBD (1.0 μL, New England Biolabs, catalog

(9) CUT&Tag for High-Resolution Epigenomic Profiling From a Low Amount of Arabidopsis TissuePlant DirectApril 10, 2026Yixuan Fu, Marc W. Schmid, Sara Simoninithen centrifuged at 31,000 × g, 4°C, for 30 min and the supernatant mixed with 5 mL Chitin Resin (NEB #S6651), previously washed first with 30 mL of ddH2O and then 20 mL of HEGX buffer. The samples were incubated

(10) A Nanobody-Based Toolbox to Probe ApoE4 in the Secretory Pathway and CytosolCellsMarch 6, 2026Laure Vandevelde, Olivier Zwaenepoel, Edith De Bruycker, Maurits Ranson, Clara Van Stichel, Charlien Matthys, Jan Gettemansintein tag fusion protein was applied to chitin beads (New England BioLabs, Ipswich, MA, USA, cat. no. S6651S) according to the manufacturer’s instructions for IMPACT purification. Purity was assessed via SDS-PAGE

(11) Cell-free chromatin state tracing reveals disease origin and therapy responsesNatureMarch 4, 2026Xubin Chen, Xiaoxuan Meng, Weilong Zhang, Xiawei Zhang, Yaping Zhang, Ping Yang, Yan Liu, Fang Bao, Sen Li, Jing Wang, et al.addition of polyethyleneimine (Sigma P3143) and clear lysate was incubated with 5 ml chitin rosin (NEB S6651L) at 4 °C for 1 h with rotation. The lysate–chitin rosin mix was loaded into a 10 ml column and washed

(12) Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell StateNat CommunFebruary 12, 2026Yusuke Tsutsui, Atsushi Masui, Satoshi Konishi, Taro Tsujimura, Mio Iwasaki, Takuya Yamamoto, Shimpei Gotoh(Addgene, 124601, a gift from Prof. Steven Henikoff) using a column filled with chitin beads (NEB, S6651L) after solubilization with sonication using Bioruptor II TYPE24 (Sonicbio, BR2024A). The transposase

(13) Inhibition of oligomeric BAX by an anti-apoptotic dimerCellDecember 24, 2025Catherine E. Newman, Micah A. Gygi, Haleh Alimohamadi, Thomas M. DeAngelo, Christina M. Camara, Julian Mintseris, Ezra Yu, Edward P. Harvey, Zachary J. Hauseman, Lixin Fan, et al.SeeBlue Plus2 Pre-Stained Protein Standard,Invitrogen,Cat# LC5925 IPTG,Gold Biotechnology,Cat# I2481C Chitin bead resin,New England Biolabs,Cat# S6651S Ni-NTA agarose,Qiagen,Cat# 30210 Sepharose CL-2B,GE Healthcare Life Sciences,Cat# 17014001 Dithiothreitol

(14) Heterochromatome wide analyses reveal MBD2 as a phase separation scaffold for heterochromatin compartmentalization and compositionNucleic Acids ResDecember 11, 2025Hui Zhang, Enes Ugur, Christian Hake, Hector Romero, Maria Arroyo, Marah Mahmoud, Frederik Lermyte, Heinrich Leonhardt, M Cristina Cardosocentrifugation at 15 000 rpm for 30 min. The cleared lysates were incubated with 2 ml chitin beads (NEB, S6651S) at 4°C with rotation for 3 h to allow CBD-chitin binding. Then beads were washed and treated in benzonase

(15) NUB1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasomeNature structural & molecular biologySeptember 1, 2025Arkinson C, Dong KC, Gee CL, Costello SM, Soe AC, Hura GL, Marqusee S, Martin A.proteins were eluted with lysis buffer supplemented with 250 mM imidazole and bound to chitin resin (S6651L, New England Biolabs), before washing in lysis buffer and overnight incubation with lysis buffer supplemented

(16) Combinatorial profiling of multiple histone modifications and transcriptome in single cells using scMTR-seqScience advancesAugust 8, 2025Wang Y, Li J, Malcolm AA, Mansfield W, Clark SJ, Argelaguet R, Biggins L, Acton RJ, Andrews S, Reik W, et al.tube was kept on ice. The supernatant of the lysed bacteria was mixed with 5 ml of chitin slurry (NEB, S6651S) and incubated on a rotator overnight at 4°C. The beads were rinsed with 20 ml of HEGX and mixed with

(17) Nucleosome spacing can fine-tune higher-order chromatin assemblyNat CommunJuly 9, 2025Lifeng Chen, M. Julia Maristany, Stephen E. Farr, Jinyue Luo, Bryan A. Gibson, Lynda K. Doolittle, Jorge R. Espinosa, Jan Huertas, Sy Redding, Rosana Collepardo-Guevara, et al.x g for 30 minutes and the supernatant was recovered. The clarified lysate was then incubated with Chitin Resin (NEB) with rocking for 2 hours. The slurry was then placed in a gravity column and the flow-through

(18) IT-scC&T-seq streamlines scalable, parallel profiling of protein-DNA interactions in single cellsGenome BiolJuly 7, 2025Jingchun Ma, Wei Jin, Li Rong, Zhanyu Gao, Zaman Hazrat, Hosen Md Shakhawat, Fei Long, Zixuan Zhang, Jiandong Huang, Xiaomei Lu, et al.and 30 s off, 40% duty. The cleared pA-Tn5-CBD protein fraction was enriched with chitin resin (NEB, S6651S) at cold-room for 2 h and further washed with 200 ml of HEGX buffer. The Tn5 protein was released by

(19) Iron-Dependent JMJD1A-Mediated Demethylation of H3K9me2 Regulates Gene Expression During Adipogenesis in a Spatial Genome Organization-Dependent MannerGenes CellsApril 28, 2025Shinnosuke Masuda, Tetsuro Komatsu, Safiya Atia, Tomohiro Suzuki, Mayuko Hayashi, Atsushi Toyoda, Hiroshi Kimura, Takeshi Inagakieliminate insoluble residues, the clarified supernatant was incubated with pre‐washed chitin resin (NEB, S6651S) at 4°C for 2 h. The resin was packed into a column (Bio‐Rad, 7,371,517) and extensively washed with

(20) Cryo-EM structures of DNA-free and DNA-bound BsaXI: architecture of a Type IIB restriction-modification enzymeNucleic Acids ResApril 15, 2025Betty W Shen, Dan Heiter, Weiwei Yang, Shuang-Yong Xu, Barry L Stoddardto remove cell debris. Crude supernatants were loaded through two separate 40 ml chitin resin (NEB S6651) columns by gravity, washed with 300 ml of chitin column buffer, and then cleaved over 3 days with 50

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Chitin Resin

Chitin Resin from New England Biolabs

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New England Biolabs

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Chitin Resin from New England Biolabs

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