THUNDER Imager Tissue from Leica Microsystems

Product Specs
ItemTHUNDER Imager Tissue
CompanyLeica Microsystems
Price Get Pricing Get Quote for this Product
Catalog NumberTHUNDER Tissue
QuantityEA
Type3D Tissue Imager
Validated ApplicationsMicroscopy, Fluorescence, Tissue Imaging, 3D Imaging
Applications3D Tissue Imaging, Fluorescence, Cleared Tissue Imaging

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Leica Microsystems

10 Parkway North Blvd., Suite 300

Deerfield, Illinois 60015

United States

Phone: 800 248 0123

Company Profile

Website: www.leica-microsystems.com

(1) Basolateral amygdala neurons await oscillatory recruitment into valence-relevant ensemblesbioRxivSeptember 20, 2026Kenneth A. Amaya, Yingchu He, Grant L. Weiss, Pantelis Antonoudiou, Jamie L. Maguireterminalis were acquired at 10x magnification using a wide-field epifluorescence microscope (Leica THUNDER Imager Tissue). Acquisition settings were optimized for each brain region and were identical across groups. Images

(2) Basolateral amygdala neurons await oscillatory recruitment into valence-relevant ensemblesResearchSquareSeptember 18, 2026Kenneth A. Maguire, Yingchu Amaya, Grant L. Weiss, Pantelis Antonoudiou, Pantelis Antonoudiouterminalis were acquired at 10x magnification using a wide-field epifluorescence microscope (Leica THUNDER Imager Tissue). Acquisition settings were optimized for each brain region and were identical across groups. Images

(3) Exploring the spatial distribution of biomolecules in Pseudomonas aeruginosa biofilms formed on PDMS and lung explants by mass spectrometry imagingBiofilmSeptember 17, 2026Marie Droniou, Clément Guillou, Hung Le, Christophe Arnoult, Teddy Grandjean, Philippe Gosset, Pascal Cosette, Isabelle SchmitzEntellan (Sigma-Aldrich) mounting medium. Slides were observed with widefield color microscopy (Leica Thunder Tissue 3D) after adding the mounting medium for at least 4 h. 2.2.3 Biofilm embedding and slicing After 24

(4) Paclitaxel induces NM2-dependent cellular contraction through GEF-H1 dissociation from microtubules and RhoA/ROCK activation in cancer cellsMol OncolSeptember 10, 2026Gloria Asensio-Juárez, Rafael Pérez-Díaz, Hugo Ramos-Solano, Marina Garrido-Casado, Vanessa C. Talayero, Miguel Vicente-ManzanaresPBS for 10 min, rinsed three times in TBS and stained as indicated. Cells were observed in a Leica Thunder Tissue Analyzer equipped with a 63× objective (NA 1.45) and appropriate LED laser lines and filters for DAPI

(5) A cortical output channel for perceptual categorizationSci AdvAugust 28, 2026Nathan A. Schneider, Michael I. Malina, Ross S. Williamsoncoverslipped (VECTASHIELD, Vector Laboratories). Images were obtained with an epifluorescence microscope (Thunder Imager Tissue, Leica) and analyzed using Fiji. Acoustic stimulation Stimuli were generated with a 24-bit digital-to-analog

(6) Molecular analysis and computational modeling reveal temporally separable responses triggered by DENV-induced soluble factors in endothelial cellsPLoS OneJuly 31, 2026Jenny Paola Alfaro-García, Julieta María Ramírez-Mejía, Paola Rojas-Estevez, Diego Alejandro Álvarez-Díaz, Geysson Javier Fernández, Carlos Alberto Orozco-Castaño, Boris Anghelo Rodríguez-Rey, Juan Carlos Gallego-Gómez, Miguel Vicente-Manzanaresand finally mounted on slides using FluorSave mounting medium. For image acquisition, we used a Leica Thunder Tissue Analyzer (Leica Microsystems, GmbH) microscope equipped with a multi-LED using a 63x objective. Data

(7) Engineered CCR2 positive macrophages coordinate immunoregulation with neural regeneration and matrix remodeling after spinal cord injuryTheranosticsJune 10, 2026Yuqi Zhao, Tao Xie, Yanming Ma, Yuhao Wang, Shenghang Liu, Hui Li, Youjun Liu, Renfeng Liu, Hailiang Xu, Cheng Ju, et al.the dark. After that, the nuclei were stained with DAPI. Fluorescence images were captured using a THUNDER Imager Tissue microscope (Leica). Apoptotic cells were quantified with ImageJ software, and the apoptotic index was

(8) Ultrastructural diversity and subcellular organization of nigral Lewy pathology in Parkinson’s diseaseNature CommunicationsJune 8, 2026Amanda J. Lewis, Lukas van den Heuvel, Marta Di Fabrizio, Kaliya Bandelier, Daria Proniakova, Domenic Burger, Notash Shafiei, Kazadi Ekundayo, Selene Offringa, Evelien Huisman, et al.incubation at room-temperature for 30 mins. 3D fluorescent images were acquired on a confocal TCS SP8 or a Thunder Tissue imager (Leica Microsystems) using a 63 x oil objective (HC PL APO/1.4 numerical aperture). The sections

(9) Mechanical Loading Induces the Radial Growth of Myofibrils and Myofibrillogenesis via an mTORC1-Dependent MechanismbioRxivMay 23, 2026Corey GK. Flynn, Ramy K. A. Sayed, Anthony N. Lange, Wenyuan G. Zhu, Troy A. Hornbergerselected regions of interest from dystrophin- and SERCA1-labeled cross-sections were imaged using a Leica THUNDER Imager Tissue 3D microscope equipped with an HC PL APO 63×/1.40 oil immersion objective. Z-stack images spanning the

(10) Chronic activity-based anorexia triggers a glial response in the hippocampus independent of intestinal epithelial toll-like receptor 4Journal of NeuroinflammationMay 18, 2026Léna Rousseau, Tanguy Demangeat, Colin Salaün, Clara Queguiner, Charlène Guérin, Christine Bôle-Feysot, Oudiayé Maiga, Adam Tiffay, Fatima Léon, Léa Cornaille, et al.analysis Images (2048 × 2048 pixels, pixel size 0.33 μm) were obtained using a widefield fluorescence Leica Thunder Imager Tissue 3D microscope (Leica Biosystems) and Las X Navigator software (Leica Microsystems, Wetzlar, Germany).

(11) Sexual Dimorphism Is Associated With Corneal Nerve and Epithelial Alterations and Tear-Film Defects in Pax6 Haploinsufficiency Mouse ModelInvest Ophthalmol Vis SciMay 18, 2026Marjolaine Willems, Mélissa Girard, Nadège Feret, Dylan Touchet, Jérôme Vialaret, Jana Kindermans, Laura Fichter, Christophe Hirtz, Dominique Bremond-Gignac, Vincent Daien, et al.acquisition was conducted as previously described.31 Whole-cornea images were captured using a Leica Thunder Imager Tissue microscope with the navigator module and the large volume computational clearing (LVCC) process. Images

(12) Bone Multicellular Unit on a Chip (BMU-Chip) Subjected to Cyclic Mechanical LoadingACS Biomaterials Science & EngineeringApril 13, 2026Anna-Blessing Merife, Michael P. Seitz, Angelika Polshikova, Ujjwal Aryal, Zachary J. Geffert, Era Jain, Jason Horton, Paola Divieti Pajevic, Pranav SomanThermofisher) and then imaged using an upright Leica DM6 B fluorescence microscope equipped with a THUNDER tissue imager. For immunostaining, the following primary and secondary antibody solutions were used in target

(13) The role of nucleus accumbens Fos expression in sex-dependent cocaine-induced locomotion, cocaine self-administration, and primed cocaine seeking in ratsBehavioural Brain ResearchApril 12, 2026Alixandria T. Mascarin, Srinivasu Kallakuri, Justin L. Carthage, Ali Gheidi, Alana C. Conti, Shane A. Perrinecatalog # DUO82040). 2.7. Microscopy and image analysis Fluorescent images were obtained using a Leica THUNDER Imager Tissue microscope at 20x magnification. Templates for measuring immunofluorescence within the regions of interest

(14) Pupil-linked arousal heterogeneously modulates cell-type-specific sensory processingSci AdvApril 3, 2026Keith J. Kaufman, Rebecca F. Krall, Ross S. Williamson(VECTASHIELD, Vector Laboratories). Fluorescence imaging was performed using an epifluorescence microscope (THUNDER Imager Tissue, Leica) at 10× magnification. Channels for green fluorescent protein (GCaMP8s) and DAPI were merged,

(15) Endothelial tPA-dependent recruitment of microglia to vessels protects the blood-brain barrier after strokeFluids and Barriers of the CNSMarch 28, 2026Tamara Etuzé, Louis Fosset, Denis Vivien, Benoit Denis Roussel, Eloise Lemarchandquantification of pericyte-microglia interactions, images were acquired in the peri-infarct area using a Leica THUNDER Imager Tissue microscope. Quantification of microglia morphology and microglia-vessel interactions Confocal images

(16) EphA2 monoclonal antibody attenuates hyperoxia-induced acute lung injury by preserving the alveolar–endothelial barrierScientific ReportsMarch 25, 2026Kyung Soo Chung, Ju Hye Shin, Su Hwan Lee, Ah Young Leem, Moo Suk Park, Jong Seok Moon, Young Sam KimFluoroshield™ mounting medium containing DAPI (Sigma-Aldrich). Fluorescent images were acquired using a THUNDER Imager Tissue microscope (Leica Microsystems, Wetzlar, Germany). The signal intensity and area of positive staining

(17) Acute and persistent neuroendocrine and behavioral alterations after social fear conditioning in adolescent male miceJ NeuroendocrinolMarch 16, 2026Anna Bludau, Melanie Kabas, Rohit Menon, Inga D. NeumannRoth GmbH & Co KG, Karlsruhe, Germany). Tissue images of the PVN and SON were acquired using a Leica Thunder Tissue Imager microscope with 20× objective lens (z‐stack with 1 μm steps), OXT (GFP: ex: 450–490, dc: 495,

(18) MYH9 mutations differentially stabilize non-muscle myosin II filaments and induce distinct cellular aggregation phenotypesCellular and Molecular Life SciencesFebruary 28, 2026Clara Llorente-González, Kamila Mustafina, Gloria Asensio-Juárez, Marina Garrido-Casado, Vanessa C. Talayero, Rafael Pérez-Díaz, Hugo Ramos-Solano, James R. Sellers, Krishna Chinthalapudi, Paul W. Wiseman, et al.buffer) and phalloidin-AlexaFluor647 to illuminate focal adhesions. Cells were observed in a Leica Thunder Tissue Analyzer equipped with a 63 × objective (NA 1.45) and appropriate LED laser lines and filters for EGFP

(19) IL-1β engages distinct peripheral sensory circuits to suppress feeding across timebioRxivFebruary 27, 2026Nikolas W. Hayes, Jessica L. Xia, Joshua A. Frydman, Marcos J. Duran, Kamil K. Gebis, Carolyn M. Lorch, Haley S. Province, Esther Tang, Lisa R. BeutlerSouthernBiotech) and EGFP fluorescence in transduced NaV1.8-positive nodose neurons was imaged on a Leica Thunder Tissue Imager. RNA isolation Nodose ganglia were harvested from NaV1.8-Cre/+ mice that had been injected

(20) Goal-directed actions and habits in head-fixed miceFrontiers in Behavioral NeuroscienceFebruary 25, 2026Logan M. Manusky, Lisa M. Green, Joshua A. Boquiren, Jade Baek, Marcus S. Bell, Kate M. Wassum, James M. Otissolutions. Coronal sections (40 μm) were cut using a cryostat, mounted on slides, and imaged on a Leica THUNDER Imager Tissue. Results Acquisition of head-fixed goal-directed and habitual reward-seeking Previous freely moving

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THUNDER Imager Tissue from Leica Microsystems

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THUNDER Imager Tissue from Leica Microsystems

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