ADME researchers have access to a wide range of in vitro products and test systems. Test-system selection should start with the scientific question and the biology the study needs to capture. How stable is the compound? Which enzymes or transporters contribute to its metabolism or degradation? Does the study require longer-term activity? Could factors such as uptake mechanisms, receptor expression, intracellular trafficking or lysosomal processing affect the relevant model? This is where fit-for-purpose product selection matters as different in vitro systems provide different levels of biological context.

In this guide from BioIVT, learn more about how to select the right ADME-Tox system with a specific research question in mind.