Seeing the fine details of the tumor microenvironment (TME) is imperative to understanding cancer genesis and progression. Spatial biology approaches are crucial for understanding the intricate relationships and interactions between these cells, tissues, and molecular components. Multiplex spatial imaging, in particular, can effectively identify co-localization patterns, elucidate the functional significance of specific cell populations, or highlight specific molecular interactions.
In this application note from Leica, learn more about an iterative staining-based multiplex spatial imaging approach for studying the complex interplay between different biomarkers within a biological system.