How to Handle Challenging Liquids

BlueskyReddit
September 21, 2026

Closed tubes containing DMSO.Air-cushion pipettes are used in almost every lab worldwide for liquid handling. These pipettes are ideal for water and aqueous solutions such as buffers and low-salt solutions but behave differently when working with challenging liquids with differing physical properties. Viscous solutions such as glycerol and DMSO are very common, but volatile liquids such as acetone or detergents are also widespread. Depending on the liquid type, improper liquid handling can lead to inappropriate volume delivery, liquid dripping, or foam formation.

In this white paper from Eppendorf, learn more about common liquid types encountered in the laboratory, as well as tips and tricks on how to handle and manipulate them using pipettes.

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