Comprehensively characterizing the spatial and phenotypic contexts of the tumor immune microenvironment (TME) in preclinical models is essential for understanding mechanisms of immune modulation and therapeutic resistance. Multiplex spatial confocal microscopy can provide insights into cellular co-localization and proximity relationships, immune cell compositional profiles, and spatial biomarker patterns.
In this poster from Leica, learn more about how multiplexed confocal imaging, paired with AI-powered analysis, uncovered critical differences between murine models of colorectal and lung cancer.