Spatial proteomics applies positional data to protein expression patterns and trends, typically in tissue samples. Fundamentally, proteins are the basic molecular unit of function in the biological cell. While other analytes can act upon, influence, and become targets of biological pathways, the protein is the molecular machine that ultimately manifests the single organismal genome into the myriad of potential differentiated cell types and structures in the body. Technological advances in spatial proteomics have allowed researchers to observe cellular dynamics in healthy and diseased tissues with unparalleled depth and breadth.
In this application note from Leica, learn more about the latest technologies and techniques available for spatial proteomics, including multiplex confocal imaging and laser microdissection.