The tumor microenvironment (TME) is central to how tumors respond to therapy, develop resistance, and metastasize. Understanding the dynamic interplay among tumor, immune, and stromal cells within this environment is essential to explaining why treatments succeed in some patients and fail in others.
In this Biocompare webinar, Wei Wei from the Institute of Systems Biology and Sizun Jiang from Harvard Medical school will discuss their multiomic efforts to map cellular interactions within the TME and identify the cell states that shape clinical outcomes. They will share findings spanning melanoma and small-cell lung cancer, along with how their labs are applying AI, including foundation models and AI agents, to decode immune responses and uncover new therapeutic targets across tumor ecosystems.
Topics to be covered:
- Spatial multiomics approaches for resolving tumor, immune, and stromal interactions in spatially organized microenvironments
- How immune checkpoint blockade primes the melanoma immune microenvironment for enhanced response to targeted therapy/immunotherapy combinations
- Coordinated macrophage, T-cell, and tumor-cell states and interactions that shape treatment response
- Clonal evolution and lineage plasticity in small-cell lung cancer, and how they connect to distinct immune and stromal niches
- Spatial architecture and immune checkpoint pathways as joint organizers of the tumor microenvironment AI foundation models and AI agents applied to spatial-omics and systems immunology