Cancer remains a highly complex disease, often influenced by factors beyond the simple point mutations that are detectable by short-read sequencing methods. Structural variants, DNA methylation, and transcript isoforms play crucial roles in tumour biology, yet legacy sequencing techniques struggle to capture these elements efficiently and comprehensively. Addressing these challenges is key to accelerating cancer research and advancing precision oncology. High-throughput nanopore sequencing allows researchers to investigate complex genomic variants at nucleotide-level resolution, enabling deeper insights into the genetic underpinnings of cancer.
In this ebook from Oxford Nanopore Technologies, learn more about how nanopore sequencing is transforming cancer genomics by delivering an unprecedented, comprehensive view of cancer biology with multiomic insights.