Multiplex immunofluorescence (mIF) has emerged as a powerful technique to simultaneously visualize and analyze multiple components of the tissue microenvironment (TME). By enabling the creation of cell and protein maps at levels of detail that include phenotypes, functional state, and interactions, mIF is revealing novel biomarkers and accelerating the development of new therapeutics based on key cell-cell interactions. In clinical settings, the technique is invaluable for determining the best course of therapy for a particular patient.
But just as the most accurate and detailed maps are drawn by the most knowledgeable and experienced cartographers, so does the best visualization and analysis of a tissue sample’s cells, proteins, and interactions come from the most experienced CRO. To maximize insights into the cellular interactions, tissue architectures, and disease processes of your samples, look no further than Multiplex Imaging & Histology CRO Services experts from Bethyl Laboratories. The CRO can support your needs across the entire imaging workflow.
With over 50 years of experience manufacturing and validating antibodies, Bethyl’s Multiplex Imaging & Histology CRO Services provide access to over 2,000 antibodies for use in immunohistochemistry and the in-house expertise to support panel development and imaging on cutting-edge platforms with up to 40-plex assays. Bethyl Laboratories is one of the only antibody manufacturers with in-house CRO services. By working with an antibody manufacturer for your multiplex imaging needs, you not only benefit from competitive pricing, but also gain access to the experts who initially manufactured and validated the antibodies for technical guidance on your individual assays.
Using Bethyl’s in-house manufactured antibodies and customization capabilities, detection of immune cells, cytokeratin, cancer markers, phospho-proteins, neurobiology markers, and various signaling pathways in human or mouse tissue can be achieved.
Create bespoke panels to meet your research goals. Offerings include core panels encompassing basic human I-O phenotypic markers, which can be expanded up to 40-plex from a library of validated antibodies or custom validation of additional antibodies.
As your CRO partner, Bethyl’s multiplexing experts will help scientists select the staining method and platform that best meets their needs by evaluating the desired number of markers, tissue format and size, and other experimental parameters. Bethyl’s CRO services provide your team access to the the Lunaphore COMET™ and the Akoya PhenoImager™ HT.
Histology services include tissue preparation for staining, including sectioning and antibody optimization for your assay. If you have brightfield slides, Bethyl can scan slides to provide you with whole slide images, be it Hematoxylin & Eosin (H&E), traditional methods using 3,3'-diaminobenzidine (DAB), or chromogenic stains.
Whether your lab is engaged in basic, translational, or clinical research, choosing Bethyl Laboratories for your Multiplex Imaging & Histology CRO Services is the first step to making the best-informed decision.