Achieving complete confidence in monoclonality while maintaining high seeding efficiency is the holy grail for cell line development. Such capabilities accelerate timelines for all stages of biotherapeutic discovery, scale-up, and manufacturing and satisfy the regulatory requirements. Currently, most methods for single-cell isolation are cumbersome and lack assurance of clonality—complicating regulatory processes and limiting process flexibility.

The new Solentim VIPS PRO from Advanced Instruments delivers highly efficient, automated single-cell seeding with industry-leading image-based clonality assurance. Its high-quality imaging, cell detection algorithm, sophisticated data management, and GMP-friendly features ensure the VIPS PRO will seamlessly integrate into cell line development for HEK, CHO, HeLA, iPSCs, and other cell types.

Be confident on Day 0

Save weeks of waiting and tedious image analysis by opting for a VIPS PRO with confirmation and documentation of a single cell in a droplet and a whole-well on Day 0.

Be confident with instant, in-well cell detection

The proprietary, AI-driven algorithm detects the single cell in the droplet deposited at the bottom of a dry well. The algorithm distinguishes it from other cells, cell aggregates, or non-cell artifacts for accurate and automatic cell recognition immediately after seeding.

Be confident in your data

Integration of STUDIUS™ software with other Solentim instruments including Cell Metric and ICON, provides powerful data analysis and management for error reduction, sample tracking, and a complete audit trail. The STUDIUS ecosystem allows for documenting the entire journey of cells through the CLD workflow all to way to Master Cell Bank generation.

Be submission-ready

VIPS PRO’s unique Double-Lock Assurance of clonality provides the image-based proof monoclonality—as expected by regulatory bodies. Daily, high-clarity, whole-well imaging tracks the timeline and confluence during clonal outgrowth, while the Clonality Report catalogs data to show the entire CLD journey, from single-cell seeding on Day 0 to colony for confident IND submission.

Be GMP-ready

GMP-certified, single-use Seeding Kits were developed specifically for clinical manufacturing to ensure ease of use, efficiency, and compatibility with GMP requirements.

Be audit-ready

Optional 21 CFR Part 11 compliant features of STUDIUS™ software provide electronic records and full traceability for a complete audit trail and digitalization of CLD records.

Taken together, the VIPS PRO delivers single-cell seeding efficiency and clonal assurance based on evidence, not probability, and will significantly compress the time it takes to advance biotherapeutic candidates from discovery to clinic.