Adoptive cell therapies such as chimeric antigen receptor (CAR) T lymphocytes and other T cell-based modalities are reshaping the future of cancer treatment. However, developing these types of products requires advanced tools to evaluate T cell function with precision, scalability, and speed. In recent years, there has been a paradigm shift away from using animal models for studying T cell population dynamics toward increased adoption of 3D biological systems. But because culturing and imaging 3D structures presents unique challenges, researchers are increasingly turning to automation for the many advantages it can provide.
This eBook explores some of the automation being used for characterizing T cells before delving into various automated assays for assessing CAR T cytotoxicity, T cell activation, and proliferation—across both 2D and 3D models.
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