Antibodies are ideal therapeutic candidates for many different medical disorders due to their unrivaled specificity and affinity for a broad range of targets. Following the U.S. FDA approval in 1986 of the first ever monoclonal antibody (mAb) therapeutic, over 100 mAbs have been approved for treating conditions including cancer, chronic inflammation, and infectious diseases. In this eBook, we look at the rise of antibody therapeutics and showcase some of the tools and technologies that are empowering antibody discovery. We also take a deep dive into how kinetic live-cell analysis is transforming mAb screening workflows.
Topics covered include:
- Functional characterization of mAbs using kinetic live-cell analysis
- Pharmacological characterization of an ADC using live-cell analysis
- Use of a real-time 96-well antibody internalization assay
- The benefits of using advanced flow cytometry and live-cell analysis for antibody profiling