Protein-protein interactions (PPIs) have a crucial role in cellular functionality and are involved in nearly all physiological processes including those associated with health and disease. As such, their characterization is integral to biotherapeutic drug discovery.
Numerous methods have emerged for studying protein-protein interactions, including biochemical, genetic, and biophysical techniques. This eBook hones in on two advanced biophysical characterization techniques—isothermal titration calorimetry (ITC), for interactions involving proteins and other species, and differential scanning calorimetry (DSC), to study protein structure stability.