Description
Pyxa is the first platform for spatial multi-omic analysis of thick tissue sections in 3D. Pyxa is an automated confocal spatial platform designed to deliver fully annotated, single-cell maps of 3D gene expression in thick tissue. The end-to-end system was intentionally designed to automate the STARmap protocol for ease of use in labs and core facilities.
3D spatial biology on Pyxa starts with thick, intact tissue sections (up to 100 µm) – up to 20 times thicker than the 5-10 µm tissue sections allowed by other platforms.
Off-the-shelf or custom gene panels, combined with kits for sample preparation, make it easy to get started. Sample preparation is in a 12-well microplate format. We currently offer sample preparation kits for 100 micron thick tissue, and an off-the-shelf panel for mouse brain. For other tissue types, customers can provide Stellaromics with a gene list for custom panel design and synthesis.
Once a sample has been processed, 3D spatial omics data can be explored using the PyxaStudio data visualization software included on the instrument workstation. Data output files are also compatible with numerous tools for single cell and spatial transcriptomic data analysis.