SONICC® Protein Crystal Detection System from FORMULATRIX

Product Specs
ItemSONICC® Protein Crystal Detection System
CompanyFORMULATRIX
Price Get Pricing Get Quote for this Product
Catalog NumberSONICC
QuantityEA
ApplicationsProtein crystallography
TypeProtein Crystallization Imager
Light SourceSecond Harmonic Generation (SHG) and Ultraviolet Two-Photon Excited Fluorescence (UV-TPEF)

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FORMULATRIX

5 DeAngelo Drive

Bedford, MA 01730

United States

Phone: +1 781 788 0228
Fax: +1 781 207 5522

Email: info@formulatrix.com

Company Profile

Website: https://formulatrix.com/

(1) Crystalline Antibody‐Laden Alginate Particles: A Platform for Enabling High Concentration Subcutaneous Delivery of AntibodiesAdvanced Healthcare MaterialsJune 1, 2023Amir Erfani, Jeremy M. Schieferstein, Paul Reichert, Chakravarthy N. Narasimhan, Cinthia Pastuskovas, Vaishali Parab, Denarra Simmons, Xiaoyu Yang, Apoorv Shanker, Paula Hammond, et al.microscope. A minimum of 30 particles were measured (ImageJ) for each sample for each reported mean diameter. SONICC (Formulatrix) was utilized to collect micrographs of microsphere samples in the following modes: bright‐field,

(2) Ultrafast structural changes direct the first molecular events of visionNatureMarch 30, 2023Thomas Gruhl, Tobias Weinert, Matthew J. Rodrigues, Christopher J. Milne, Giorgia Ortolani, Karol Nass, Eriko Nango, Saumik Sen, Philip J. M. Johnson, Claudio Cirelli, et al.with various types of buffer and the first hit detected using the second harmonic generation imaging SONICC (second order nonlinear optical imaging of chiral crystals) device (Formulatrix)61. For crystal growth,

(3) High-Throughput Screening to Obtain Crystal Hits for Protein CrystallographyJournal of Visualized ExperimentsMarch 27, 2023Gabrielle R. Budziszewski, M. Elizabeth Snell, Tiffany R. Wright, Miranda L. Lynch, Sarah E. J. Bowmanphosphate-tribasic,Molecular Dimensions,MD2-100-309, Potassium thiocyanate,Hampton Research,HR2-695, Rock Imager 1000 with SONICC,Formulatrix,, Rock Imager 54,Formulatrix,, Rubidium chloride,Millipore Sigma,R2252-10G, SaltRx HT

(4) 20 years of crystal hits: progress and promise in ultrahigh-throughput crystallization screeningActa Crystallographica Section D Structural BiologyMarch 1, 2023Miranda L. Lynch, M. Elizabeth Snell, Stephen A. Potter, Edward H. Snell, Sarah E. J. Bowmanmacromolecular crystals. The workhorse of the imaging pipeline is the Formulatrix Rock Imager 1000 with SONICC (RI-1000), which enables enhanced crystal imaging using second-harmonic generation (SHG) and ultraviolet

(5) Polo: an open-source graphical user interface for crystallization screeningJournal of Applied CrystallographyApril 1, 2021Ethan T. Holleman, Erica Duguid, Lisa J. Keefe, Sarah E. J. Bowman(visible) microscopy. In addition, the Crystallization Center uses a Formulatrix Rock Imager 1000 with SONICC (second-order nonlinear imaging of chiral crystals), which enables ultraviolet two-photon excited fluorescence

(6) C-phycocyanin as a highly attractive model system in protein crystallography: unique crystallization properties and packing-diversity screeningActa Crystallographica Section D Structural BiologyFebruary 1, 2021Iosifina Sarrou, Christian G. Feiler, Sven Falke, Nolan Peard, Oleksandr Yefanov, Henry Chapmanwere incubated at 22°C and automatically imaged by second-order nonlinear imaging of chiral crystals (SONICC; Formulatrix, Bedford, Massachusetts, USA). The presence of crystalline material (>1 µm) was verified

(7) A fully automated crystallization apparatus for small protein quantitiesActa Crystallographica Section F Structural Biology CommunicationsJanuary 1, 2021Ryuichi Kato, Masahiko Hiraki, Yusuke Yamada, Mikio Tanabe, Toshiya SendaFormulatrix, Massachusetts, USA; Fig. 2 ▸ b). In addition to the RockImager2, we installed a benchtop SONICC (Formulatrix), which can image crystals by second-harmonic generation (SHG) and ultraviolet two-photon

(8) Protein-crystal detection with a compact multimodal multiphoton microscopeCommunications BiologyDecember 1, 2020Qing-di Cheng, Hsiang-Yu Chung, Robin Schubert, Shih-Hsuan Chia, Sven Falke, Celestin Nzanzu Mudogo, Franz X. KaÌˆrtner, Guoqing Chang, Christian BetzelDominik Oberthür and Henry Chapman (CFEL/DESY) for performing imaging experiments at the Formulatrix SONICC system. Open Access funding enabled and organized by Projekt DEAL. Author contributions C.B., G.Q.C.

(9) Construction of gateway-compatible baculovirus expression vectors for high-throughput protein expression and in vivo microcrystal screeningScientific ReportsDecember 1, 2020Yanyang Tang, Justin Saul, Nirupa Nagaratnam, Jose M. Martin-Garcia, Petra Fromme, Ji Qiu, Joshua LaBaersuspension was loaded into a 96-well 2-drop MRC Crystallization Plate (Swissci) and immediately imaged with SONICC imager (Formulatrix) using visible light and the SHG technology to visualize and identify the in vivo-grown

(10) Remote opener: breaking barriers to crystallization using remote crystal growth screening and imagingActa Crystallographica Section A Foundations and AdvancesAugust 2, 2020Sarah Bowmanwith very small sample volumes integrated with advanced imaging and a Formulatrix Rock Imager with SONICC for rapid detection of crystal growth. The current pipeline in the Crystallization Center screens for

(11) Enhanced X-ray diffraction of in vivo-grown μNS crystals by viscous jets at XFELsActa Crystallographica Section F Structural Biology CommunicationsJune 1, 2020Nirupa Nagaratnam et al.second-harmonic generation (SHG), which is indicative of nano/microcrystals (Wampler et al., 2008 ▸), with a SONICC imager (Formulatrix; https://formulatrix.com/) using visible-light and second-harmonic generation (SHG)

(12) Pembrolizumab microgravity crystallization experimentationnpj MicrogravityDecember 1, 2019Paul Reichert et al.standard setting 110 mW, and SHG high-power setting 450 mW. Crystallinity was verified by Formulatrix SONICC™ analyses on samples of each bottle analyzed in a Whatman Fast Frame 4 slide well plate after a 1:10

(13) Calibration-Free Second Harmonic Generation (SHG) Image Analysis for Quantification of Trace Crystallinity Within Final Dosage Forms of Amorphous Solid DispersionsApplied SpectroscopyNovember 1, 2018Casey J. Smith, Janny Dinh, Paul D. Schmitt, Paul A. Stroud, Jeremy Hinds, Michael J. Johnson, Garth J. Simpsonconducted in Second Harmonic Generation Second harmonic generation images were acquired using a modified SONICC (second order nonlinear imaging of chiral crystals) instrument from Formulatrix (Formulatrix, USA),

(14) Rapid sample delivery for megahertz serial crystallography at X-ray FELsIUCrJSeptember 1, 2018Max O. Wiedorn et al.4°C. The crystallinity of the PS I sample was confirmed using second-harmonic generation spectroscopy (SONICC, Formulatrix, USA) in tandem with UV microscopy to confirm protein content. The mean size and the size

(15) Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallographyNatureJanuary 1, 2017J. R. Stagno et al.crystalsMicrocrystals of apo-rA71 were grown using batch crystallization as described in Methods. A SONICC Imager (Formulatrix) was used to image each sample (0.5–1.0 µl) of crystals using three different methods:

(16) Protein Crystallization in an Actuated Microfluidic Nanowell DeviceCrystal Growth & DesignSeptember 30, 2016Bahige G. Abdallah, Shatabdi Roy-Chowdhury, Raimund Fromme, Petra Fromme, Alexandra Rosusing bright-field microscopy, UV fluorescence, and second-order nonlinear imaging of chiral crystals (SONICC; Formulatrix, USA). For the calibration experiments with fluorescein, the chip was allowed to rest for

(17) Characterization of Protein Nanocrystals Based on the Reversibility of CrystallizationCrystal Growth & DesignJuly 6, 2016Katerina Dörner, Jose M. Martin-Garcia, Christopher Kupitz, Zhen Gong, T. Conn Mallet, Liqing Chen, Rebekka M. Wachter, Petra Frommeproteins in an ordered scaffold such as in tissues and biological membranes.31 The commercially available SONICC instrument (Formulatrix Inc.) relies on the same principle and is a user-friendly setup with the focus

(18) The detection and subsequent volume optimization of biological nanocrystalsStructural DynamicsJuly 1, 2015Joseph R. Luft, Jennifer R. Wolfley, Eleanor Cook Franks, Angela M. Lauricella, Ellen J. Gualtieri, Edward H. Snell, Rong Xiao, John K. Everett, Gaetano T. Montelioneat 14 °C, immediately following 4 °C incubation. Additionally, a Formulatrix Rock Imager 1000 with SONICC (Bedford, MA) was used to record three types of image data, Visible, Second Harmonic Generation (SHG),

(19) Intercalating dyes for enhanced contrast in second-harmonic generation imaging of protein crystalsActa Crystallographica Section D Biological CrystallographyJuly 1, 2015Justin A. Newman, Nicole M. Scarborough, Nicholas R. Pogranichniy, Rashmi K. Shrestha, Richard G. Closser, Chittaranjan Das, Garth J. Simpsonboth malachite green and crystal violet dyes. The well plates were imaged using the automated SHG microscope SONICC (Formulatrix). 3. Results and discussion The results of malachite green intercalation into lysozyme protein

(20) Batch crystallization of rhodopsin for structural dynamics using an X-ray free-electron laserActa Crystallographica Section F Structural Biology CommunicationsJuly 1, 2015Wenting Wu, Przemyslaw Nogly, Jan Rheinberger, Leonhard M. Kick, Cornelius Gati, Garrett Nelson, Xavier Deupi, Jörg Standfuss, Gebhard Schertler, Valérie Panneelsal., 2011 ▸) in parallel with Ultraviolet Two-Photon Excited Fluorescence (UV-TPEF) imaging using a SONICC (second-order nonlinear imaging of chiral crystals) imager (Formulatrix; Wampler et al., 2008 ▸). While

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