Fig 1: Levels of ROS (A), GSH (B), MnSOD (C), catalase (D), IL-6 (E), and TNF-α (F) in the left ventricles (LVs) of all groups of rats. Data were analyzed for n = 10 samples/group and were significantly different p < 0.05. a: vs. the control rats; b: vs. the control + ASX-treated rats; c: vs. HFD-fed rats, d: vs. HFD + ASX-treated rats. EX-527: a selective SIRT1 inhibitor.
Fig 2: Levels of ROS (A), MDA (B), MnSOD (C), and GSH (D), mRNA levels of Nrf2 € and HO-1 (HO-1), and nuclear protein levels of Nrf2 in the LVs of all experimental groups. For each group (n = 8), the data are given as mean ± SD. Levels of significance were considered at p < 0.05. a: compared to control group; b: compared to the control + urolithin A; c: compared to STZ, d: compared to STZ + urolithin A.
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