Fig 1: Visceromotor responses following adult pretreatment with lipopolysaccharide (LPS). In (A) AUC (Area-Under-the Curve) statistics presenting overall vigor of visceromotor responses to graded urinary bladder distension following adult pretreatment with varying concentrations of LPS normalized to the No-LPS pretreatment AUC statistic (see text for greater description) of each neonatal treatment group. NBI indicates Neonatal Bladder Inflammation treatment group; NCT indicates Neonatal Control Treatment group. In (B and C) the stimulus response functions from which the normalized data was derived. Note that NCT had minimal responses to adult LPS treatment, whereas NBI rats demonstrated robust dose-dependent augmentation of their visceromotor responses. All values presented as Mean ± SEM. * and ** represent statistically significant differences from the No-LPS adult pretreatment group with p<0.05 and p<0.01 respectively.