Description
Adiponectin receptor protein 1 serves as a receptor for ADIPOQ, a crucial hormone secreted by adipocytes that regulates glucose and lipid metabolism. It is vital for maintaining normal glucose and fat homeostasis, as well as body weight. In mice, Adiponectin receptor protein 1 (AdipoR1) fulfills various essential roles, including regulating energy metabolism, protecting the cardiovascular system, inhibiting inflammatory responses, and participating in endocrine and neuroprotective functions. Mice lacking adiponectin experience a significant increase in arterial calcification, whereas mice overexpressing adiponectin demonstrate notable improvements in insulin sensitivity, linked to elevated adiponectin levels in adipose tissue