Description
Aspartate Aminotransferase, also referred to as GOT1, facilitates the biosynthesis of L-glutamate from either L-aspartate or L-cysteine. This enzyme plays a crucial role in regulating the amount of glutamate, which is the primary excitatory neurotransmitter in the vertebrate central nervous system. It serves a protective function in the brain by scavenging glutamate. Additionally, aspartate aminotransferase activity is essential for hepatic glucose synthesis during development and for glyceroneogenesis in adipocytes. In rabbits, this enzyme is encoded by the GOT1 gene