Fig 1: Carboplatin induces proinflammatory macrophage phenotypes. A, Gene expression TNFα, IL1β, IL10, TGFβ, and CCL22 in THP1- and PBMC-derived macrophages following 48 hours of carboplatin treatment (275 µmol/L) relative to M0 vehicle. Unpaired t test. B, Protein expression of LEGENDplex Immune Response panel and TNF family panel of THP1- (left) and PBMC-derived macrophage (right) supernatants after 48 hours of carboplatin treatment (275 µmol/L) relative to vehicle. n = 3. Actual concentrations are in Supplementary Fig. S3 (see bar graphs). Mean and SEM. *, P < 0.05, no stars indicate ns.