3CL Protease, MBP-tagged (SARS-CoV-2) Assay Kit 79955-2 from BPS Bioscience, Inc.

Product Specs
Item3CL Protease, MBP-tagged (SARS-CoV-2) Assay Kit
CompanyBPS Bioscience, Inc.
Price $1,295.00Supplier Page View Company Product Page
Catalog Number79955-2
Quantity384 reactions
TypeAssay Kit
ApplicationsGreat for studying enzyme kinetics and HTS applications

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BPS Bioscience, Inc.

6405 Mira Mesa Blvd

Suite 100

San Diego, CA 92121

United States

Phone: 858-202-1401

Email: sales-team@bpsbioscience.com

Company Profile

Website: https://bpsbioscience.com/

(1) Integration of metabolomics and chemometrics with in-silico and in-vitro approaches to unravel SARS-Cov-2 inhibitors from South African plantsPLoS OneMarch 26, 2025Karabo Maselepe Makoana, Clarissa Marcelle Naidoo, Muhammad Sulaiman Zubair, Mmei Cheryl Motshudi, Nqobile Monate Mkoloenzyme inhibition of SARS-CoV-2 3CLpro was conducted as per the manufacturer’s instructions (Cat. No. 79955-1). Prior to initiation of the enzyme reaction, pre-incubation of 30 µl diluted 4 ng 3CLpro-MBP tagged

(2) Design, Synthesis, Biological Evaluation and Molecular Docking Studies of New Thiazolidinone Derivatives as NNRTIs and SARS‐CoV‐2 Main Protease InhibitorsChemistry & BiodiversityDecember 1, 2024Maria Fesatidou, Anthi Petrou, Athina Geronikakiperformed using SARS‐CoV‐2 specific 3CLpro assay kit which was purchased from BPS Biosciences (Catalog #79955‐1, San Diego, CA, USA). The assay was carried out following the manufacturer's protocol. Briefly, 5 ng

(3) Investigation of phytochemicals isolated from selected Saudi medicinal plants as natural inhibitors of SARS CoV-2 main protease: In vitro, molecular docking and simulation analysisSaudi Pharm JMarch 29, 2024Yousef T.M. Alharbi, Wael M. Abdel-Mageed, Omer A. Basudan, Ramzi A. Mothana, Md Tabish Rehman, Ali A. ElGamal, Ali S. Alqahtani, Omer I. Fantoukh, Mohamed F. AlAjmicompounds, the 3CL Protease, MBP-tagged (SARS-CoV-2) Assay Kit was employed. The assay kit (catalog #79955–1) was procured from BPS Bioscience Inc. (San Diego, CA, USA) and consisted of purified MBP-tagged recombinant

(4) Discovery of Pyrano[2,3-c]pyrazole Derivatives as Novel Potential Human Coronavirus Inhibitors: Design, Synthesis, In Silico, In Vitro, and ADME StudiesPharmaceuticals (Basel)February 2, 2024Abdou K. Allayeh, Aliaa H. El-boghdady, Mohamed A. Said, Mahmoud G. A. Saleh, Mohammed T. Abdel-Aal, Mohamed G. AboueleneinProtease (SARS-CoV2) inhibition test was executed using the 3CL Protease Test Kit (Catalogue Number #79955-1; BPS Bioscience, San Diego, CA, USA). The 3CL protease, known as the Main Protease (Mpro), is essential

(5) Diacerein reduces inflammasome activation and SARS-CoV-2 virus replication: a proof-of-concept translational studyFrontiers in pharmacologyJanuary 1, 2024Carmo HRP, Castillo AR, Bonilha I, Gomes EIL, Barreto J, Moura FA, Davanzo GG, de Brito Monteiro L, Muraro SP, Fabiano de Souza G, et al.caspase-1 from ABclonal (RK01035). The activity of the 3CL protease, MBP-tag (SARS-CoV-2; catalogue 79955-1) and papain-like protease (SARS-CoV-2; catalogue 79995) were both from BPS bioscience. Finally, a caspase-1

(6) Development and Evaluation of a Self-Nanoemulsifying Drug Delivery System for Sinapic Acid with Improved Antiviral Efficacy against SARS-CoV-2PharmaceuticsOctober 25, 2023Hani A. Alhadrami, Ahmed S.G. Srag El-Din, Hossam M. Hassan, Ahmed M. Sayed, Albaraa H. Alhadrami, Mostafa E. Rateb, Demiana M. Naguibin vitro enzyme inhibition activities using a 3CL Protease, tagged (SARS-CoV-2) Assay Kit (Catalogue #: 79955-1, BPS Bioscience, Inc., Allentown, PA, USA) according to the manufacturer’s protocol. The in vitro FRET assay

(7) Korupensamine A, but not its atropisomer, korupensamine B, inhibits SARS-CoV-2 in vitro by targeting its main protease (Mpro)European Journal of Medicinal ChemistryMay 5, 2023Ahmed M. Sayed, Alyaa Hatem Ibrahim, Nasir Tajuddeen, Jürgen Seibel, Jochen Bodem, Nina Geiger, Kathrin Striffler, Gerhard Bringmann, Usama Ramadan Abdelmohsenin vitro enzyme inhibition activities using 3CL Protease, tagged (SARS-CoV-2) Assay Kit (Catalogue #: 79955-1, BPS Bioscience, Inc., Allentown, PA, USA), according to manufacturer's protocol [5]. The in vitro FRET assay

(8) Agathisflavone, a natural biflavonoid that inhibits SARS-CoV-2 replication by targeting its proteasesInternational Journal of Biological MacromoleculesDecember 1, 2022OtÃ¡vio Augusto Chaves, Carlyle Ribeiro Lima, Natalia Fintelman-Rodrigues, Carolina Q. Sacramento, Caroline S. de Freitas, Leonardo Vazquez, Jairo R. Temerozo, Marco E.N. Rocha, Suelen S.G. Dias, Nicolas Carels, et al.determined by the commercial kit provided by BPS Bioscience® company (catalog number: #79995-1 and #79955-1, respectively) following the procedure and recommendations from literature and manufacturer [53], [54],

(9) Theaflavin 3-gallate inhibits the main protease (Mpro) of SARS-CoV-2 and reduces its count in vitroScientific ReportsDecember 1, 2022Mahima Chauhan et al.value. In vitro inhibition assay of Mpro MBP-tagged (SARS-CoV-2) assay kit was used (Catalogue No. #79955-1; BPS Bioscience, USA) to study the inhibition of Mpro by theaflavin 3-gallate. GC376 and theaflavin

(10) A ricin-based peptide BRIP from Hordeum vulgare inhibits Mpro of SARS-CoV-2Scientific ReportsDecember 1, 2022Prakriti Kashyap, Vijay Kumar Bhardwaj, Mahima Chauhan, Varun Chauhan, Asheesh Kumar, Rituraj Purohit, Arun Kumar, Sanjay Kumarcharacterization. In vitro inhibition assay of Mpro MBP-tagged (SARS-CoV-2) assay kit was used (Cat. No. Catalog #79955-1; BPS Bioscience, USA) to study the inhibition of Mpro by BRIP. In brief, the reactions were performed

(11) Garcinia cambogia Phenolics as Potent Anti-COVID-19 Agents: Phytochemical Profiling, Biological Activities, and Molecular DockingPlants (Basel)September 26, 2022Hanan Y. Aati, Ahmed Ismail, Mostafa E. Rateb, Asmaa M. AboulMagd, Hossam M. Hassan, Mona H. Hettaprotocol of the manufacturer, the assay performed used SARS-CoV-2 proteases assay kits (MPro, Catalog: 79955-1, BPS Bioscience, Inc., Allentown, PA, USA), using GC376 (MW = 507.5 Dalton) as the positive control.

(12) Apixaban, an orally available anticoagulant, inhibits SARS-CoV-2 replication and its major protease in a non-competitive wayJournal of Molecular Cell BiologySeptember 21, 2022Otávio Augusto Chaves et al.and GC376 (positive control) for 88.8 nM Mpro, assayed by commercial FRET kit (BPS Biosciences Ltd, #79955-1). (B) Michaelis–Menten enzymatic inhibition for Mpro in the absence or presence of a fixed apixaban

(13) Eryngium creticum L.: Chemical Characterization, SARS-CoV-2 Inhibitory Activity, and In Silico StudyACS OmegaJuly 5, 2022Marwa Elsbaey, Mahmoud A. A. Ibrahim, Ahmed M. Shawky, Tomofumi Miyamoto

(14) Commercially Available Flavonols Are Better SARS-CoV-2 Inhibitors than Isoflavone and FlavonesVirusesJune 30, 2022Chaves OA, Fintelman-Rodrigues N, Wang X, Sacramento CQ, Temerozo JR, Ferreira AC, Mattos M, Pereira-Dutra F, Bozza PT, Castro-Faria-Neto HC, et al.velocity of SARS-CoV-2 Mpro was determined using a commercial kit (BPS Biosciences®, catalog number: #79955-1) following the procedure and recommendations from the literature and manufacturer [31,32]. This enzymatic

(15) Versisterol, a new endophytic steroid with 3CL protease inhibitory activity from Avicennia marina (Forssk.) VierhRSC AdvancesApril 22, 2022Marwa Elsbaey, Mahmoud A. A. Ibrahim, Mohamed-Elamir F. Hegazy

(16) Thiazole/Thiadiazole/Benzothiazole Based Thiazolidin-4-One Derivatives as Potential Inhibitors of Main Protease of SARS-CoV-2MoleculesMarch 28, 2022Anthi Petrou, Panagiotis Zagaliotis, Nikoleta F. Theodoroula, George A. Mystridis, Ioannis S. Vizirianakis, Thomas J. Walsh, Athina Geronikakiperformed using SARS-CoV-2 specific 3CLpro assay kit, which was purchased from BPS Biosciences (Catalog #79955-1, San Diego, CA, USA). The assay was carried out following the manufacturer’s protocol. Briefly, 5 ng

(17) Instant determination of the artemisinin from various Artemisia annua L . extracts by LC‐ESI‐MS/MS and their in‐silico modelling and in vitro antiviral activity studies against SARS‐CoV‐2Phytochemical AnalysisMarch 1, 2022Kubra Dogan et al.molecules against main protease enzyme were screened with 3CL Protease (SARS‐CoV‐2), MBP‐tagged Assay Kit (#79955–2, BPS Bioscience, San Diego, CA, USA). Artemisinin and its derivatives were solubilised to 100 mM stock

(18) Neoechinulin A as a Promising SARS-CoV-2 Mpro Inhibitor: In Vitro and In Silico Study Showing the Ability of Simulations in Discerning Active from Inactive Enzyme InhibitorsMarine DrugsFebruary 24, 2022Hani A. Alhadrami, Gaia Burgio, Bathini Thissera, Raha Orfali, Suzan E. Jiffri, Mohammed Yaseen, Ahmed M. Sayed, Mostafa E. Ratebin vitro enzyme inhibition activities using 3CL Protease, tagged (SARS-CoV-2) Assay Kit (Catalog #: 79955-1, BPS Bioscience, Inc., Allentown, PA, USA), according to manufacturer’s protocol [15]. The in vitro

(19) The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studiesMolecular TherapyFebruary 2, 2022Serdar Durdagi, Timucin Avsar, Muge Didem Orhan, Muge Serhatli, Bertan Koray Balcioglu, Hasan Umit Ozturk, Alisan Kayabolen, Yuksel Cetin, Seyma Aydinlik, Tugba Bagci-Onder, et al.In vitro enzyme inhibition assays were carried out using SARS-CoV-2 3CL Protease assay kit (#79955-1 and #79955-2, BPS Bioscience, San Diego CA) and in accordance with manufacturer's protocol. A 100 mM stock concentration

(20) Screening of Clinically Approved and Investigation Drugs as Potential Inhibitors of SARS‐CoV‐2: A Combined in silico and in vitro StudyMolecular InformaticsFebruary 1, 2022Serdar Durdagi, Muge Didem Orhan, Busecan Aksoydan, Seyma Calis, Berna Dogan, Kader Sahin, Aida Shahraki, Necla Birgül Iyison, Timucin Avsarchemiluminescence, that can be measured using a chemiluminescence reader. 3CL Protease Assay Kit (#79955‐1 and #79955‐2, BPS Bioscience, San Diego CA, USA) was used to screen the activity of main protease. Figure 4 represents

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3CL Protease (SARS-CoV-2) Assay Kit-384 reactions

3CL Protease, MBP-tagged (SARS-CoV-2) Assay Kit from BPS Bioscience, Inc.

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BPS Bioscience, Inc.

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3CL Protease, MBP-tagged (SARS-CoV-2) Assay Kit from BPS Bioscience, Inc.

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