Fig 1: The miR-299a-5p agomir inhibits SCI-induced inflammation and NLRP3 inflammasome. (a) MPO activity in the spinal cord from mice treated with the miR-299a-5p agomir or agomir-NC. (b) IL-6 and TNF-a levels in the spinal cord. (c) Western blot images and quantification of p65 phosphorylation. (d) Relative NF-?B transcriptional activity. (e) Western blot images and quantification of NLRP3, ASC, and casp1 p10. (f) Relative casp1 activity. (g) IL-1ß and IL-18 levels in the spinal cord. n = 6 for each groups. Data are expressed as the mean ± standard deviation, and P < 0.05 was considered statistically significant.