Fig 1: a Log-ratios of plasma EPO levels at day 14 p.i. for mice infected with SI-lines or COI-lines after 7 passages. b Log-ratios of plasma HO-1 levels at day 14 p.i. for mice infected with SI-lines or COI-lines after 5 or 7 passages. Log-ratios are computed as ln(yevolved/meanancestral). The dotted line represents no change with respect to hosts infected with the ancestral Py population. Dots represent the raw data, the boxes represent the interquartile range (IQR), the horizontal lines the median, and whiskers the range of data within 1.5 the IQR. Numbers just above the x-axis represent the sample size per group