Fig 1: Investigation of protein signatures of diseases based on cVAE modeling. (A) Heatmap showing the top 10 protein markers for disease groups, including AD_PD_MG (AD_PD_MG vs. HC_ON_NMOSD), sub_AD (AD vs. PD_MG_HC), and sub_PD (PD vs. AD). (B) Relative abundance of the top protein marker in each group. (C) Overexpression of HSPG2 confirmed in PD patients compared to AD by ELISA (left, AD, n = 15; PD, n = 6); Overexpression of LRG1 confirmed in AD patients compared to HC and MG by ELISA (right, AD, n = 14; HC, n = 12; MG, n = 15). (D) Overexpression of LRG1 was characterized in AD patients compared to HC, PD, MG, ON, and NMOSD by LC-MS analysis (n = 3, pooled samples)