Fig 1: Parishin reduces senescent markers of vascular tissues and serum in naturally aged mice. (A) Temporal schematic diagram of the experimental procedures. (B, C) Western blotting and quantification of lamin B1and IL‐6 in vascular tissue of different groups. (D) The degree of vascular fibrosis was investigated by Masson's trichrome staining (magnification 40×). (E) The corresponding quantitative data of Masson's trichrome staining. (F) Serum GDF15, CXCL9 and sFlt1 levels in different groups were measured using ELISA kits. *p < 0.05 versus Control mice.