Fig 1: The effects of W1302 on NO production and activities of eNOS or iNOS in SHR-2VO rats. SHR-2VO rats: permanent occlusion of bilateral common carotid arteries in spontaneously hypertensive rats; WKY rats: age-matched Wistar Kyoto rats as non-hypertensive sham-operated control. (A,B) The nitric oxide assay kit for detecting the production of NO (n = 8). (C) EC50 value of cGMP production in SKN cells after 4 h of incubation with W1302 (n = 4). (D–G) eNOS and iNOS were analyzed by Elisa kits (n = 8). Data were expressed as mean ± S.E.M. # p < 0.05 vs. WKY rats and * p < 0.05, ** p < 0.01, vs. SHR-2VO rats.
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