Description
The progression of the cell cycle is controlled by a complex interplay of cell cycle regulators that either stimulate or inhibit the cell from entering each stage of the cell cycle. These molecules activate transcription factors which bind to DNA to turn on or off the production of proteins which result in cell division. Dysfunction of any step in this regulatory cascade causes abnormal cell proliferation, which underlies many human pathological conditions, most notably cancer and aging. A crucial area in understanding these conditions is to understand the mechanisms underlying alterations in cell cycle progression