Fig 1: Brain Aβ levels and brain and kidney APP levels in 5xFAD and NAC-treated 5xFAD mice. (A) Mean brain Aβ40 levels (ng/mg tissue) were lower for NAC-treated 5xFAD mice (p = 0.017). (B) No changes in mean brain Aβ42 levels (μg/mg protein) were noted between groups. (C) NAC treatment did not associate with differences in brain APP levels (µg/mg tissue). (D) Levels of kidney APP were elevated (p = 0.005) in association with NAC treatment (ng/mg tissue). Circles represent technical replicates. Data are presented as mean (filled columns) ± standard error of the mean (SEM).