Control CRISPR/Cas9 Plasmid from Santa Cruz Biotechnology, Inc.

Product Specs
ItemControl CRISPR/Cas9 Plasmid
CompanySanta Cruz Biotechnology, Inc.
Price $84.00Supplier Page View Company Product Page
Catalog Numbersc-418922
Quantity20 µg
Nucleic Acid TypeCRISPR Negative Controls
Vector Type (Standardized)Plasmid
TypePlasmid

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) SPNS2 exports sphingosine-1-phosphate and imports glucoseNat CommunApril 20, 2026Cynthia Weigel, Md Lokman Hossen, Ryan D. R. Brown, Can E. Senkal, Christopher D. Green, Jason Newton, Sumit Saha, Elisa N. D. Palladino, Bin Ni, Francesco S. Celi, et al.corresponding to the cut sites generated by the SPNS2 CRISPR/Cas9 KO Plasmid. Control CRISPR/Cas9 Plasmids (#sc-418922, Santa Cruz Biotechnology) were used to generate control cells. Transfections were carried out as described

(2) Impact of SETD8/KMT5A overexpression on hepatocellular carcinoma progression and prognosisPLoS OneApril 13, 2026Norihiko Suzaki, Shinya Hayami, Atsushi Miyamoto, Masashi Nakamura, Tomohiro Yoshimura, Kensuke Nakamura, Yoshinobu Shigekawa, Atsushi Shimizu, Yuji Kitahata, Akihiro Takeuchi, et al.Pr-Set7 HDR plasmid (h2) (sc-41579-HDR-2, Santa Cruz Biotechnology), and control CRISPR/Cas9 plasmid (sc-418922, Santa Cruz Biotechnology). We performed plasmid transfection using UltraCruz Transfection Reagent (sc-395739,

(3) Fibroblasts of disparate developmental origins harbor anatomically variant scarring potentialCellFebruary 5, 2026Michelle F. Griffin, Dayan J. Li, Kellen Chen, Jennifer B.L. Parker, Jason L. Guo, Seungsoo Kim, Katerina Kraft, Mauricio Downer, Annah G. Morgan, Maxwell M. Kuhnert, et al.Plasmid,Santa Cruz Biotechnology,Cat# sc-425516-ACT Control CRISPR/Cas9 Plasmid,Santa Cruz Biotechnology,Cat# sc-418922 Control CRISPR Activation Plasmid,Santa Cruz Biotechnology,Cat# sc-437275 Robo2 CRISPR/Cas9 KO Plasmid,Santa Cruz Biotechnology

(4) PARP14 is an interferon-induced host factor that promotes IFN production and affects the replication of multiple virusesmBioOctober 8, 2025Srivatsan Parthasarathy, Pradtahna Saenjamsai, Hongping Hao, Anna Ferkul, Jessica J. Pfannenstiel, Daniel S. Bejan, Yating Chen, Ellen L. Suder, Nancy Schwarting, Masanori Aikawa, et al.PARP14 CRISPR/Cas9 KO plasmid (sc-402812, Santa Cruz Biotechnology) or control CRISPR/Cas9 plasmid (sc-418922, Santa Cruz Biotechnology) using PolyJet transfection reagent according to the manufacturer’s instructions.

(5) BRG1 Loss Is Frequent in Lung Cancer and Transforms Lung Epithelial Cells via Transcriptional and Epigenetic ReprogramingCancers (Basel)September 22, 2025Mathewos Tessema, Christin M. Yingling, Loryn M. Phillips, Kieu Do, Maria A. Picchi, Randy Willink, Steven A. Belinsky(sc-400168) and the Brg-1 HDR Plasmid (sc-400168-HDR) or a non-targeting Control CRISPR/Cas9 Plasmid (sc-418922), all obtained from Santa Cruz Biotechnology Inc. (Dallas, TX, USA), as described by the manufacturer.

(6) RORγt Inhibition Reduces Pro-Tumor Inflammation and Decreases Tumor Growth in Experimental Models of Lung CancerCancer Immunology ResearchSeptember 2, 2025Miki Yamada-Hara, Lauren Amaya, Zhihe Wang, Ji Won Byun, Naoki Takahashi, Sunandini Sharma, Han Chang, Arisachi Tanaka, Liping Zeng, Zahra Malakoutikhah, et al.KO in LLC cells LLC cells were either left non-transfected or transfected with control CRISPR/Cas9 (sc-418922) or RORγ CRISPR/Cas9 KO (sc-422700) and RORγ HDR (sc-422700-HDR) plasmids (all from Santa Cruz Biotechnology).

(7) GPT2 mediates glutamine metabolism-driven metabolic alterations in platinum-resistant ovarian cancer cellsSci RepAugust 20, 2025Adriana Ponton-Almodovar, Mary P. Udumula, Vrinda Khullar, Faraz Rashid, Ramandeep Rattan, Jamie J. Bernard, Sachi HoribataGPT2 following protocol provided by the company. Control CRISPR/Cas9 Plasmid (Santa Cruz Biotech, Cat# sc-418922) was used to create non-targeting control (NTC) clones. Successful transfected clones were selected

(8) Danshenol B alleviates central post-stroke pain by regulating the PIK3CG/NLRP3 signaling pathwayJ Transl MedJune 23, 2025Panyang Li, Linna Yu, Jinzhong Yao, Tingting Zhao, Sen ZhaoActivation Particles (LV-NC, SC-437282, Santa Cruz Biotechnology) or Control CRISPR/Cas9 Plasmid (sh-NC, SC-418922, Santa Cruz Biotechnology) were injected into the same stereotaxic coordinates in separate groups of

(9) Tet Methylcytosine Dioxygenase 3 Promotes Cardiovascular Senescence by DNA 5-Hydroxymethylcytosine-Mediated Sp1 Transcription Factor ExpressionMedComm (2020)June 19, 2025Yanqi Dang, Jing Ma, Shuang Ling, Shurong Wang, Huining Guo, Jun Liu, Guang Ji, Jin-Wen Xu(sc‐414997) and TET3 HDR plasmid(h) (sc‐414997‐HDR) were used, with the control CRISPR/Cas9 plasmid (sc‐418922) as negative control, all of which were purchased from Santa Cruz. The HUVECs were seeded in a 24‐well

(10) PER2 expression and cellular localization play a critical role in tumor aggressiveness and drug resistance in an in vitro model of hepatocellular carcinomaCancer Drug ResistJune 3, 2025Mariarosaria Negri, Feliciana Amatrudo, Donatella Paola Provvisiero, Roberta Patalano, Giovanna Trinchese, Fabiano Cimmino, Cristina de Angelis, Chiara Simeoli, Renata Simona Auriemma, Maria Pina Mollica, et al.Santa Cruz Biotechnology, Inc.) for 3 days. Control PLC/PRF/5 parental cells were created using control plasmid (sc-418922; Santa Cruz, Inc.) according to the manufacturing instructions. To confirm complete PER2 allelic KO,

(11) A dataset of adult heart and liver mass after placental Insulin-like growth factor 1 overexpression and partial knockout in micebioRxivMay 30, 2025Faith M Fairbairn, Annemarie J Carver, Robert J Taylor, Hanna E Stevensas (Igf1-KO), Control CRISPR Activation Plasmid (sc-437275)(ConAct), or Control CRISPR/Cas9 plasmid (sc-418922) (ConCas9) (All plasmids from Santa Cruz Biotechnology). Here, Igf1-KO is hypomorphic with Igf1 expression

(12) GPT2 mediates metabolic alterations in platinum-resistant ovarian cancer cellsResearchSquareMay 9, 2025Adriana Ponton-Almodovar, Mary Priyanka Udumula, Vrinda Khullar, Faraz Rashid, Ramandeep Rattan, Jamie J. Bernard, Sachi HoribataGPT2 following protocol provided by the company. Control CRISPR/Cas9 Plasmid (Santa Cruz Biotech, Cat# sc-418922) was used to create non-targeting control (NTC) clones. Successful transfected clones were selected

(13) Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunityNature communicationsApril 14, 2025Huang Y, Zhong WQ, Yang XY, Shan JL, Zhou L, Li ZL, Guo YQ, Zhang KM, Du T, Zhang HL, et al.populations. All knockout clones were identified by immunoblot. Control CRISPR/Cas9 Plasmid (Cat. sc-sc-418922) from Santa Cruz Co. was used as a negative control. The knockout cells were identified by immunoblot. For

(14) Placental Igf1 Overexpression Sex-Specifically Impacts Mouse Placenta Structure, Altering Offspring Striatal Development and BehaviorbioRxivMarch 29, 2025Annemarie J. Carver, Faith M. Fairbairn, Robert J. Taylor, Shanmukh Boggarapu, Njenga R. Kamau, Amrita Gajmer, Hanna E. Stevenspaper Recombinant DNA,Recombinant DNA,Recombinant DNA Control CRISPR/Cas9 plasmid,Santa Cruz Biotechnology,sc-418922 Control CRISPR Activation Plasmid,Santa Cruz Biotechnology,sc-437275 IGF-I CRISPR Activation Plasmid

(15) PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451BiomaterialsMarch 1, 2025Divya Bhansali, Nguyen H. Tu, Kenji Inoue, Shavonne Teng, Tianyu Li, Hung D. Tran, Dong H. Kim, Jessy Dong, Chloe J. Peach, Badr Sokrat, et al.(Santa Cruz Biotechnology, Cat# sc-400333-HDR) and control CRISPR-Cas9 plasmid (Santa Cruz Biotechnology, Cat# sc-418922). The control CRISPR-Cas9 plasmid encodes the Cas9 nuclease and a non-specific 20 nt guide RNA. A mixture

(16) Loss of TC-PTP in keratinocytes leads to increased UVB-induced autophagyCell Death DiscoveryFebruary 28, 2025Obed Asare, Lindsey Shim, Cheol-Jung Lee, Jose Delgado, Natasha Quailes, Klarissa Zavala, Junsoo Park, Bilal Bin Hafeez, Yong-Yeon Cho, Subhash C. Chauhan, et al.plasmid targeting TC-PTP (sc-403071, Santa Cruz Biotechnology) or the corresponding control plasmid (sc-418922, Santa Cruz Biotechnology). For UVB exposure, the cells were washed with prewarmed DPBS and then irradiated

(17) MAGE-A4 induces non-small cell lung cancer and tumor-promoting plasma cell accumulationScience advancesFebruary 14, 2025Armstrong D, Chang CY, Hong MJ, Green L, Shen Y, Hudson W, Mauk KE, Song LZ, Jammi S, Casal B, et al.H1299 cells using CRISPR plasmid and control scramble plasmid (Santa Cruz Biotechnology, sc-403486 and sc-418922) and Lipofectamine 3000 (Thermo Fisher Scientific), following the manufacturer’s protocol specific for

(18) OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastomaNature communicationsFebruary 4, 2025Desai K, Wanggou S, Luis E, Whetstone H, Yu C, Vanner RJ, Selvadurai HJ, Lee L, Vijay J, Jaramillo JE, et al.with guide RNAs targeting Olig2 (Santa Cruz, sc-424530) and a control CRISPR/Cas9 plasmid (Santa Cruz, sc-418922) was purchased from Santa Cruz Biotechnologies. Ptch1+/−;Trp53−/− MB cells (PTCP53 304) were cultured

(19) Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFosBritish Journal of CancerJanuary 30, 2025Andrew Hartley, Laura C. A. Galbraith, Robin Shaw, Amy Tibbo, Rajan Veeratterapillay, Laura Wilson, Rakesh Heer, Karen Blyth, Hing Leung, Imran Ahmadfollowing selective pressure. A CRISPR/Cas9 control plasmid with a non-specific guide RNA (Santa Cruz, sc-418922) and an in-house Infra-Red Fluorescent Protein (IRFP) plasmid were used as a control with puromycin

(20) TMEM160 Promotes Tumor Growth in Lung Adenocarcinoma and Cervical Adenocarcinoma Cell LinesInternational journal of molecular sciencesJanuary 27, 2025Herrera-Quiterio GA, Valencia-González HA, de la Cruz-López KG, Fernández-Coto DL, Gil J, Marko-Varga G, Morales-Gálvez J, Sánchez NC, Rodríguez-Bautista R, Avilés-Salas A, et al.the TMEM160 CRISPR/Cas9 KO (sc-411396), TMEM160 HDR (sc-412396-HDR) plasmids, and control plasmid (sc-418922) from Santa Cruz Biotechnology, Dallas, TX, USA. Transfection was performed using Lipofectamine reagent

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