Fig 1: Prognostic potential of the Timeless gene in patients with lung cancer analyzed using Kaplan–Meier plotter. High expression of the Timeless gene was associated with (A,C) poor OS and (B,D) poor PFS of patients with lung squamous cell carcinoma and lung adenocarcinoma. (G,H) Timeless gene expression was of prognostic value for patients with lung cancer irrespective of their smoking habits. (I,J) High expression of the Timeless gene was associated with poor OS of both males and females. (E,F) Timeless gene expression was associated with poor OS and PFS of patients with lung squamous cell carcinoma, while it was not associated with those of patients with lung squamous cell carcinoma. PFS, progression-free survival; OS, overall survival; HR, hazard ratio (presented with 95% CI).
Fig 2: Genetic mutational and correlational analysis of Timeless gene in the patients with lung adenocarcinoma. (A,B) Correlation analysis between the Timeless gene and its co-expressed genes using the cBioPortal tool. (C) Genetic mutational analysis of the Timeless gene in lung adenocarcinoma. (D) Pearson correlation analysis between Timeless and ESPL1 genes using the GEPIA database. ESPL1, extra spindle pole bodies like 1.
Fig 3: Genetic mutational and correlational analysis of Timeless genes in the patients with lung squamous cell carcinoma. (A,B) Correlation analysis between the Timeless gene and its co-expressed genes using the cBioPortal tool. (C) Genetic mutational analysis of the Timeless gene in lung squamous cell carcinoma. (D) Pearson correlation analysis between Timeless and ESPL1 genes using the GEPIA database. ESPL1, extra spindle pole bodies like 1.
Fig 4: Association of Timeless gene expression with clinicopathological parameters of patients with lung cancer. (A,C,E,G) Timeless gene expression and clinicopathological parameters of patients with LUSC. (B,D,F,H) Timeless gene expression and clinicopathological parameters of patients with LUAD. # p < 0.05 vs. normal group; @ p < 0.05 vs. cancer stage 4; $ p < 0.05 vs. female group. TCGA, The Cancer Genome Atlas; LUSC, lung squamous cell carcinoma; LUAD, lung adenocarcinoma.
Fig 5: Expression profile of the Timeless gene from (A–G) Oncomine database. Expression profile of Timeless gene in seven lung cancer datasets. (H) Comparison of Timeless gene in the seven analyses.
Supplier Page from Sino Biological, Inc. for Human TIMELESS Gene ORF cDNA clone expression plasmid