XRN-1 from New England Biolabs

Product Specs
ItemXRN-1
CompanyNew England Biolabs
Price $100.00 Inquire
Catalog NumberM0338S
Quantity20 units
ApplicationsFunctional Genomics
Temperature-20 C

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New England Biolabs

240 County Road

Ipswich, Massachusetts 1938

United States

Phone: 800-632-5227
800-632-7799
978-921-1350

Company Profile

Website: http://www.neb.com

(1) A key role for the exoribonuclease XRN1 in regulating the hepatitis B viral transcriptomeiScienceJuly 17, 2026Senko Tsukuda, Nadina Wand, James M. Harris, Olivia Dobrica, Medhi Boutasbih, Xiaxuan Zhu, Peter A.C. Wing, Peter Balfe, Jane A. McKeatingpreS12-48,This paper,N/A mRNA Decapping Enzyme,New England Biolabs,Cat# M0608S XRN1,New England Biolabs,Cat# M0338S ,, Critical commercial assays,Critical commercial assays,Critical commercial assays ,, HiScribe T7 High Yield RNA Synthesis kit

(2) Generation of precise and accurate engineered circRNAs using enzymatic ligationNucleic Acids ResMay 8, 2026Amrita Singh, Adela Dujsikova, Noah Mueller, Y Grace Chenassay One microgram of monophosphorylated RNA mixture was treated with 1 unit of XRN1 enzyme (NEB #M0338S) at 37°C for 60 min. Triphosphorylated RNAs were used as negative controls. The reactions were purified

(3) Precise measurement of molecular phenotypes with barcode-based CRISPRi systemsGenome BiolMay 25, 2025Joseph H. Lobel, Nicholas T. IngoliaDNAse treatment of the cycloheximide treated samples, 10 µg of RNA was treated with 1 µL Xrn1 (NEB, M0338S) for 1 h at 37 °C to remove decapped, 5′ phosphorylated mRNAs before being purified by spin column.

(4) 5′ terminal nucleotide determines the immunogenicity of IVT RNAsNucleic Acids ResearchJanuary 24, 2025Magdalena Wolczyk, Jacek Szymanski, Ivan Trus, Zara Naz, Tola Tame, Agnieszka Bolembach, Nila Roy Choudhury, Karolina Kasztelan, Juri Rappsilber, Andrzej Dziembowski, et al.purified total RNA sample was treated in three different conditions – without enzyme, with XRN-1 (NEB #M0338S) alone, or with XRN-1 and RppH (NEB #M0356S) together. Reactions were performed at 37°C for 60 min in

(5) Precise measurement of molecular phenotypes with barcode-based CRISPRi systemsbioRxivSeptember 10, 2024Joseph H. Lobel, Nicholas T. IngoliaDNAse treatment of the cycloheximide treated samples, 10 μg of RNA was treated with 1 μL Xrn1 (NEB, M0338S) for 1 h at 37 °C to remove decapped, 5’ phosphorylated mRNAs before being purified by spin column.

(6) Stimulation of interferon-β responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonistsiScienceJanuary 20, 2023Arai Y, Yamanaka I, Okamoto T, Isobe A, Nakai N, Kamimura N, Suzuki T, Daidoji T, Ono T, Nakaya T, et al.Reagent,Mirus,Cat# MIR 2154 TransIT®-mRNA Transfection Kit,Mirus,Cat# MIR 2225 XRN-I,New England Biolabs,Cat# M0338S RNA 5′ Pyrophosphohydrolase (RppH),New England Biolabs,Cat# M0356 Xba I,TAKARA Bio,Cat# 1093A Hind

(7) Alternative cleavage and polyadenylation generates downstream uncapped RNA isoforms with translation potentialMolecular cellOctober 20, 2022Malka Y, Alkan F, Ju S, Körner PR, Pataskar A, Shulman E, Loayza-Puch F, Champagne J, Wenzel C, Faller WJ, et al.deactivation. XRN1 treatment For RNA-seq analysis DNase I-treated, poly(A) selected RNA was treated with XRN1 (NEB M0338S) according to the manufacturer’s instructions followed enzyme deactivation. Illumina RNA-sequencing RNA

(8) Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1iScienceJuly 15, 2022Vabret N, Najburg V, Solovyov A, Gopal R, McClain C, Šulc P, Balan S, Rahou Y, Beauclair G, Chazal M, et al.3115887001 TRI Reagent LS,Sigma,Cat: # T3934 5′-phosphate-dependent XRN-1,New England BioLabs,Cat: #M0338S ,, Critical commercial assays,Critical commercial assays,Critical commercial assays ,, EasySep Human CD4+ T Cell Isolation Kit

(9) Identification of RNA Fragments Resulting from Enzymatic Degradation using MALDI-TOF Mass SpectrometryJournal of Visualized ExperimentsApril 25, 2022Shawn W. Schowe, Conner J. Langeberg, Erich G. Chapman, Kitty Brown, Marino J. E. ResendizAesar,12125–01–8, Bruker bacterial test standard,Bruker Daltonics,8255343, Commercial source of Xrn-1,New England BioLabs,M0338S, "Diethyl pyrocarbonate, 97%",ACROS Organics,A0368487, Flex analysis software,Bruker daltonics,,"FlexAnalysis

(10) Spatio-temporal characterization of the antiviral activity of the XRN1-DCP1/2 aggregation against cytoplasmic RNA viruses to prevent cell deathCell death and differentiationAugust 1, 2020Ng CS, Kasumba DM, Fujita T, Luo H.in vitro synthesized and cell-purified RNA were subjected to digestion by recombinant XRN1 protein (NEB, #M0338S) according to manufacturer’s protocol. Lentiviral vectors and generation of MDA5 CRISPR/Cas9-deficient

(11) Unraveling the mechanistic features of RNA polymerase II termination by the 5′-3′ exoribonuclease Rat1Nucleic Acids ResearchMarch 11, 2015Jieun Park, Myungjin Kang, Minkyu Kimand rai1 (E221A, D223A) were prepared by site-directed mutagenesis. Xrn1 was purchased from NEB (cat# M0338S). The rat1 E203A/D233A/D235A (rat1EDD) mutant was generated by polymerase chain reaction mutagenesis

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XRN-1

XRN-1 from New England Biolabs

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New England Biolabs

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XRN-1 from New England Biolabs

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