PromethION 2 Integrated Benchtop Nanopore Sequencer from Oxford Nanopore Technologies

Product Specs
ItemPromethION 2 Integrated Benchtop Nanopore Sequencer
CompanyOxford Nanopore Technologies
Price Get Pricing Get Quote for this Product
Catalog NumberPromethION 2 Integrated
QuantityEA
Run TimeUp to 72 hours
Dimensions(WxDxH) 225 x 430 x 180 mm
Maximum OutputTwo high-output flow cells. 100–200 Gb/flow cell; 200–400 Gb/device.
Read LengthFrom 20 bp to over 4 Mb
Weight10.6 kg

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Oxford Nanopore Technologies

Gosling Building Edmund Halley Road

Oxford Science Park

Oxford OX4 4DQ

United Kingdom

Phone: +44 (0)845 034 7900

Company Profile

Website: nanoporetech.com

(1) Discovery of novel circular RNAs of the apoptosis-related BAX gene in breast cancer, by combining nanopore and next-generation sequencingMol Genet GenomicsMarch 17, 2026Katerina Katsaraki, Giannis Vatsellas, Christos K. Kontosassessment of the quality and the representation of the libraries. Next, the pool was sequenced in a PromethION 2 Solo sequencer (Oxford Nanopore Technologies, Oxford, UK) using the R10 chemistry. Next-generation sequencing

(2) Bradyrhizobium denitrificans strain SoilA , isolated from dryland mesquite litter soil in Arizona, USA, grows using calcium oxalate as a sole carbon sourceMicrobiology Resource AnnouncementsMarch 12, 2026Alexander Sonke, Christine Quan, Elizabeth Trembath-Reichert(#SQK-NBD114). Long fragment buffer was used to promote longer read lengths. Sequencing was performed on the PromethION 2 Solo platform using a FLO-PRO114M Flow Cell (R10 version). Sequencing was performed with a translocation

(3) Comparative Genome Analysis of Illumina, Nanopore, and Hybrid Approaches: A Case Study of the Aquaculture Isolate 160PPathogensMarch 6, 2026Izzet Burcin Saticioglu, Janset Bozkurt, Muhammed DumanBioinformatics Resource Center (BV-BRC) Fastq Utilities pipeline. Long-read sequencing was performed on an ONT PromethION 2 Solo platform (Oxford Nanopore Technologies, Oxford, UK) using an R10.4.1 flow cell (FLO-PRO114M). Libraries

(4) First whole-genome assembly of the Galápagos Petrel ( Pterodroma phaeopygia ) using Oxford Nanopore sequencing to advance conservation genomics in a critically endangered seabirdG3: Genes, Genomes, GeneticsMarch 4, 2026Isabella R Sessi, James B Henderson, Jessica A Martin, Alice Skehel, Gabriela Pozo, Jonathan A Guillén Alcides, Vera de Ferran, John P Dumbacher, Jaime A ChavesDNA Sequencing Kit (SQK-ULK114), and sequenced on three PromethION 2 flow cells (FLO-PRO114M) using the PromethION 2 Solo (P2 Solo) platform. A second library was prepared from the same sample in January 2025 during a follow-up

(5) Novel transposon Tn 8026 acts as a global driver of transmissible linezolid resistance in Enterococcus via a linear plasmidmedRxivMarch 4, 2026Michael B Hall, Yiyang Xue, Tricia S E Lee, Ella Herring, Jocelyn Hume, Ryan R Wick, Timothy Kidd, Naomi Runnegar, Patrick N A Harris, Bianca Graves, et al.High-molecular-weight DNA was extracted using the QIAamp® PowerFecal® Pro DNA Kit (QIAGEN) and sequenced on the PromethION 2 Solo (Oxford Nanopore Technologies). Raw data were basecalled with Dorado (v1.1.1) using the super-accuracy

(6) Dynamic modulation of N6-methyladenosine by ionizing radiation in human cellsBiochem Biophys RepMarch 2, 2026L. Cruz-Garcia, Philip Davies, Veronika Goriacha, Mustafa Najim, Stanislav Polozov, Maria Polozova, Christophe BadieKit (Thermo Fisher Scientific) to ensure accurate input concentrations. Sequencing was performed on a PromethION 2 Solo device (Oxford Nanopore Technologies) with R9 flow cells, which were primed using the Flow Cell Priming

(7) The Complete Chloroplast Genome of a Vietnam Endemic Aroid, Homalomena perplexa K.Z.Hein, Vuong, Bao & V.S.Dang, and Updated Comparative Genomics in AraceaeEcol EvolFebruary 27, 2026Nhat Nam Nguyen, Ngoc Trai Nguyen, Hoang Dang Khoa Doprotocol. The library was then sequenced using a PromethION flow cell (R10.4.1, FLO‐PRO114M) and a PromethION 2 Solo device, monitored by MINKNOW v24.11.10 with a High Accuracy option for the basecalling process. The

(8) An alternative technique for organelle genome recovery in diatoms using culture-independent, minimal-cell whole genome amplificationPeerJFebruary 25, 2026Aimee Caye G. Chang, Mailor W.W. Amaral, Kyle Keepers, Catherine Ikudaisi, Megan Greenwood, Jingchun Li, Sarah E. Hamsher, Scott R. Miller, John Patrick KociolekKit (SQK-NBD114), with Long Fragment Buffer to enhance read lengths. Sequencing was conducted on the PromethION 2 Solo platform using an R10 version FLO-PRO114M Flow Cell at a translocation speed of 400 bps. Base calling

(9) Basecalling-free resistance gene identification using a hybrid transformer in raw nanopore signalsFrontiers in MicrobiologyFebruary 18, 2026Roman Jakubicek, Jevhenij Vorochta, Marketa Jakubickova, Matej Bezdicek, Martina Lengerova, Helena VitkovaBarcoding Kit 96 V14 (Oxford Nanopore Technologies, Oxford, UK). Sequencing was performed using the PromethION 2 Solo sequencing platform (Oxford Nanopore Technologies, Oxford, UK) with R10.4.1 flow cells, and the obtained

(10) Transient telomere uncapping triggers telomeric and subtelomeric rearrangementsEMBO ReportsFebruary 17, 2026Liébaut Dudragne, Clotilde Garrido, Oana Ilioaia, Juliana Silva Bernardes, Zhou Xuet al, 2021)",N/A Other,Other,Other MK1C Minion sequencer,Oxford Nanopore Technologies,MIN-101C PromethION 2 Solo sequencer,Oxford Nanopore Technologies,PRO-SEQ002 CHEF-DR III System,Bio-Rad,962BR1898 Reagents

(11) Transmission of MPXV from fire-footed rope squirrels to sooty mangabeysNatureFebruary 11, 2026Carme Riutord-Fe, Jasmin Schlotterbeck, Lorenzo Lagostina, Leonce Kouadio, Harriet R. Herridge, Moritz J. S. Jochum, Nea Yves Noma, Ane López-Morales, Donata Hoffmann, Sten Calvelage, et al.using the Rapid-Barcoding Kit v.14 (Oxford Nanopore Technologies) and sequenced them directly on a PromethION 2 solo platform (Oxford Nanopore Technologies) using R10.4.1 PromethION flow cells. Basecaller v.4.3.0 was

(12) Methylation profile characteristics in the H19/IGF2:IG-DMR revealed by long-read sequencing analysis in patients with Beckwith-Wiedemann syndrome having defects in the OCT4/SOX2 binding siteClinical EpigeneticsFebruary 3, 2026Hayate Masubuchi, Tatsuki Urakawa, Rika Kosaki, Riki Nishimura, Yasunori Wada, Sumito Dateki, Hideaki Yagasaki, Reiko Kagawa, Yutaka Nishimura, Hidenobu Soejima, et al.subjected to MinION or PromethION flow cells (R10.4.1) and sequenced the libraries with the GridION Mk1 or PromethION 2 solo (ONT) device under MinKNOW v22.12.5 or v23.11.7 (ONT) control. We washed the flow cell with the Flow

(13) Retroviral insertions contributed to the divergence of human and chimpanzee brainsbioRxivDecember 12, 2025Patricia Gerdes, Ofelia Karlsson, Raquel Garza, Diahann A.M. Atacho, PingHsun Hsieh, Bharat Prajapati, Chandramouli Muralidharan, Anita Adami, Carrie Davis-Hansson, Emily M. Johansson, et al.R10.4.1 on a PromethION platform (Oxford Nanopore Technologies) at SciLifeLab Uppsala or in-house on a PromethION 2 Solo (Oxford Nanopore Technologies) for 72 hours. Long-read DNA analysis Raw sequencing data (POD5 format)

(14) Trichosporon austroamericanum Infections among Hospitalized Patients, France, 2022-2024Emerg Infect DisDecember 11, 2025Emilie Burel, Catherine Sartor, Valérie Moal, Vincent Bossi, Jacques Sevestre, Justine Solignac, Rémi Charrel, Marie Desnos-Ollivier, Stéphane Ranque, Estelle Menu× 150 bp. We also performed nanopore sequencing on individually sequenced genomic DNA by using the PromethION 2 Solo or GridION and the LSK109 Ligation Kit on a FLO-PRO002 flow cell (all Oxford Nanopore Technologies,

(15) Long-read sequencing transcriptome quantification with lr-kallistoPLoS Comput BiolDecember 1, 2025Rebekah K. Loving, Delaney K. Sullivan, Fairlie Reese, Elisabeth Rebboah, Jasmine Sakr, Narges Rezaie, Heidi Y. Liang, Ghassan Filimban, Shimako Kawauchi, A. Sina Booeshaghi, et al.FLO-MIN114) with an input of 20 fmol and 12 fmol, respectively. Sequencing was performed on the GridION and PromethION 2 Solo instruments using the MinKNOW software. Bases were called from reads with Oxford Nanopore base-calling

(16) Genomic characterization and SNP analysis connect respiratory infections caused by Mycobacterium intracellulare with a pool facilityMicrob GenomDecember 1, 2025Caitlin A. Selway, Lisa Shephard, Michaela Hobby, Koen Vandelannoote, Chris Lease, David Cunliffe, Jamie Woodward, Timothy P. Stinear, Mark Turra, Simone Barry, et al.SQK-NBD114.96 (Oxford Nanopore Technologies, Oxford, UK) and sequenced on an Oxford Nanopore Technologies (ONT) PromethION 2 Solo platform with a PromethION R10.4.1 flow cell (FLO-PRO114M, Oxford Nanopore Technologies, Oxford, UK).

(17) Leveraging artificial intelligence community analytics and nanopore metagenomic surveillance to monitor early enteropathogen outbreaksFrontiers in Public HealthNovember 26, 2025Jeff Gauthier, Sima Mohammadi, Irena Kukavica-Ibrulj, Brian Boyle, Chrystal Landgraff, Lawrence Goodridge, Kenton White, Benjamin Chapman, Roger C. Levesquesequencing Throughout the monitoring timeline, samples were sequenced using Oxford Nanopore Technologies (ONT)‘s PromethION 2 solo platform. Briefly, 1 μg input DNA was processed with the Ligation Sequencing Kit v14 (SQK-LSK114) as

(18) Mutation of CMTR2 in Lung Adenocarcinoma Alters RNA Alternative Splicing and Reveals Therapeutic VulnerabilitiesNature communicationsNovember 6, 2025Nukaga S, Shiraishi K, Hamabe K, Mochizuki A, Hamaguchi Y, Ogawa E, Le NT, Shimada Y, Ono H, Nishinakamura H, et al.Technologies) according to the manufacturer’s instructions. The prepared libraries were sequenced on a PromethION 2 Solo instrument (Oxford Nanopore Technologies) over 72 h. Base calling was performed using Dorado basecaller

(19) Genetic exchange networks bridge mobile DNA vehicles in the bacterial pathogen Listeria monocytogenesNature CommunicationsNovember 4, 2025Héloïse Muller, Odion O. Ikhimiukor, Manuela Montoya-Giraldo, Kathryn R. Piper, Maitiú Marmion, Seth L. Blumerman, Lisa Mingle, Samantha E. Wirth, Kimberlee A. Musser, William J. Wolfgang, et al.(#SQK-NBD114). Long Fragment Buffer was used to promote longer read lengths. Sequencing was performed on the PromethION 2 Solo platform using a FLO-PRO114M Flow Cell (R10 version) with a translocation speed of 400 bps. Base calling

(20) Phenotypic markers misclassify isolates of Salmonella Typhimurium as S. Typhi, but were correctly identified by whole genome sequencing during a septicemia study in western KenyaPLOS Glob Public HealthOctober 23, 2025Joseph Kaingu, Kimita Gathii, Carolyne Kifude, James Nonoh, Lillian Ogonda, Amos Onditi, Kirti Tiwari, John Waitumbiinstructions. 200 μL of the prepared DNA library was loaded into an R10.4.1 flow cell and then sequenced on the PromethION 2 Solo instrument (Oxford Nanopore Technologies, Oxford, UK) for a maximum of 72 hours. Raw pod5 files from

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