UG 100™ Sequencing Platform from Ultima Genomics

Product Specs
ItemUG 100™ Sequencing Platform
CompanyUltima Genomics
Price Get Pricing Get Quote for this Product
Catalog NumberUG 100
Read Length225 bp, 300 bp
Maximum Reads12 B
Maximum Output3.6 Tb
Run Time12 to 14 hours
Sample ThroughputUp to 6 amplified sample pools

(1) A single-cell cytokine dictionary of human peripheral bloodbioRxivApril 23, 2026Lukas Oesinghaus, Sören Becker, Larsen Vornholz, Efthymia Papalexi, Joey Pangallo, Amir Ali Moinfar, Jenni Liu, Alyssa La La Fleur, Maiia Shulman, Simone Marrujo, et al.sublibrary was then converted into an Ultima Genomics-compatible sequencing library and sequenced on the UG-100 sequencer at approximately 31,000 mean reads per cell. Split-pipe processing Fastq files generated

(2) Evaluation of the Ultima Genomics UG 100 sequencer for low-cost, high-sensitivity metagenomic pathogen detection from cerebrospinal fluidMicrobiology SpectrumApril 7, 2026Ryan C. Shean, Keith D. Tardif, Alexandra Rangel, Jacob Dutrschi, David Bogumil, Alix Cruse, Samm Hernandez, Nika Iremadze, Sarah Pollock, Doron Lipson, et al.Evaluation of the Ultima Genomics UG 100 sequencer for low-cost, high-sensitivity metagenomic pathogen detection from cerebrospinal fluid

(3) Genotype-to-phenotype mapping of somatic clonal mosaicism via single-cell co-capture of DNA mutations and mRNA transcriptsCancer DiscovApril 1, 2026Dennis J Yuan, John Zinno, Theo Botella, Dalia Dhingra, Shu Wang, Allegra G Hawkins, Ariel Swett, Jesus Sotelo, Ramya Raviram, Clayton Hughes, et al.manufacturer’s protocol, before a final clean up step. The quantified library was sequenced on Ultima Genomics UG100 to 15X genome-wide coverage per cell. 500-kb windows were used to determine coverage along driver gene

(4) Integrated inference of cancer gene expression from cell-free plasma chromatinbioRxivFebruary 23, 2026Gunsagar S. Gulati, Damien Vasseur, Rashad Nawfal, Shahabeddin Sotudian, Karl Semaan, Marc Eid, Ji-Heui Seo, Noa Phillips, John J. Canniff, Hunter Savignano, et al.(M2673; 20 ng) cancer patients from the MOSCATO–2 clinical trial were sequenced on the Ultima Genomics UG100 platform using XGen adapters. The mean genome coverage was 120× for M2594 and 138× for M2673 and the

(5) Genome-wide single-cell perturbation screens with VIPerturb-seqbioRxivFebruary 16, 2026Alexandra Bradu, John D. Blair, Isabella N. Grabski, Isabella Mascio, Junsuk Lee, Cecilia McCormick, Rahul Satijathroughput are achievable with the same workflow. Sequencing was performed using an Ultima Genomics UG100 instrument, and we recovered approximately 880,000 cell barcodes across two lanes (Figure 3D). Robustness

(6) Opportunities for RNA sequencing in physiology: from big data to understanding homeostasis and heterogeneityFunction (Oxf)February 1, 2026Jeremy W. Prokop, Stephanie M. Bilinovich, Ember Tokarski, Sangeetha Vishweswaraiah, Sophie VanderWeele, Akansha S. Das, Surya B. Chhetri, Alexander Dao, Sanjana Arora, Austin Goodyke, et al.Illumina-based sequencing, with newer companies such as Element Biosciences' AVITI platform and Ultima Genomics UG 100 elevating a new competitive sequencing market. The cost of these machines can represent a significant

(7) Genotype-to-phenotype mapping of somatic clonal mosaicism via single-cell co-capture of DNA mutations and mRNA transcriptsCancer DiscoveryDecember 31, 2025Dennis J. Yuan, John Zinno, Theo Botella, Dalia Dhingra, Shu Wang, Allegra G. Hawkins, Ariel Swett, Jesus Sotelo, Ramya Raviram, Clayton Hughes, et al.manufacturer’s protocol, before a final clean up step. The quantified library was sequenced on Ultima Genomics UG100 to 15X genome-wide coverage per cell. 500-kb windows were used to determine coverage along driver gene

(8) Benchmarking of duplex sequencing approaches to reveal somatic mutation landscapesbioRxivDecember 18, 2025Yang Zhang, Vinayak V. Viswanadham, Michail Andreopoulos, Dominik Glodzik, Ruolin Liu, Lovelace J. Luquette, Se-Young Jo, Azeet Narayan, Muchun Niu, Lisa Anderson, et al.(Applied Biosystems) and Fragment Analyzer (Agilent). ppmSeq libraries were sequenced on Ultima Genomics (UG100) instruments according to manufacturer instructions. NanoSeq: NanoSeq HpyCH4V and NanoSeq Mung Bean

(9) A single-cell cytokine dictionary of human peripheral bloodResearch SquareDecember 12, 2025Fabian Oesinghaus, Lukas Oesinghaus, Larsen Vornholz, Efthymia Vornholz, Efthymia Papalexi, Amir Ali Pangallo, Jenni Moinfar, Alyssa La Fleur, Alyssa La Shulman, Simone Shulman, et al.sublibrary was then converted into an Ultima Genomics-compatible sequencing library and sequenced on the UG-100 sequencer at approximately 31,000 mean reads per cell. Split-pipe processing Fastq files generated

(10) Large-scale single-cell phylogenetic mapping of clonal evolution in the human aging esophagusbioRxivOctober 25, 2025Tamara Prieto, Dennis J. Yuan, John Zinno, Clayton Hughes, Nicholas Midler, Sheng Kao, Jani Huuhtanen, Ramya Raviram, Foteini Fotopoulou, Neil Ruthen, et al.converted to Ultima Genomics (UG) libraries by PCR-based conversion kit (Ultima Genomics), and sequenced on UG100 sequencer at target of 15× coverage. Standard-PTA+RNA vs SMART-PTA benchmark To compare the performance

(11) An automated ATAC-seq method reveals sequence determinants of transcription factor dose response in the open chromatinbioRxivJuly 29, 2025Betty B. Liu, Masaru Shimasawa, Sidney Vermeulen, Samuel H. Kim, Nika Iremadze, Doron Lipson, Zohar Shipony, William J. Greenleaf(paired end 150 cycles). TF dose RoboATAC libraries were converted for sequencing on the Ultima Genomics UG 100 sequencer via a conversion PCR reaction (Ultima Protocol Guide D1001055 Rev 01) using 10ng of input

(12) Atlas-scale single-cell DNA methylation profiling with sciMETv3Cell GenomicsJanuary 8, 2025Ruth V. Nichols, Lauren E. Rylaarsdam, Brendan L. O’Connell, Zohar Shipony, Nika Iremadze, Sonia N. Acharya, Andrew C. Adeysequence read priming would eliminate the issue, such as a design compatible with the Ultima Genomics UG100 instrument. Atlas-scale dataset production is possible with sciMETv3 on multiple sequencing platforms To

(13) Applying whole-genome and whole-exome sequencing in breast cancer: a review of the landscapeBreast CancerNovember 1, 2024Hetvi Ganatra, Joecelyn Kirani Tan, Ana Simmons, Carola Maria Bigogno, Vatsala Khurana, Aruni Ghose, Adheesh Ghosh, Ishika Mahajan, Stergios Boussios, Akash Maniam, et al.particularly in underdeveloped and developing countries. To address this issue, the Ultima Genomics UG 100 system, launched on February 6, 2024, represents a significant advancement. This system integrates new

(14) Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesisNature CancerOctober 30, 2024Yizhou Zhu, Hayan Lee, Shannon White, Annika K. Weimer, Emma Monte, Aaron Horning, Stephanie A. Nevins, Edward D. Esplin, Kristina Paul, Gat Krieger, et al.following the manufacturer’s guidance. Sequencing was carried out using the novel ultrahigh-throughput UG-100 (Ultima Genomics) sequencer. mHi-C data processing Initial processing of mHi-C data was executed using

(15) NucBalancer: streamlining barcode sequence selection for optimal sample pooling for sequencingGigabyteOctober 11, 2024Saurabh Gupta, Ankur Sharmaintroduction of additional sequencing platforms by Element Biosciences (AVITI System) and Ultima Genomics (UG100). These new entrants are rapidly gaining attention, each offering unique advantages that contribute

(16) The Space Omics and Medical Atlas (SOMA) and international astronaut biobankNatureAugust 29, 2024Eliah G. Overbey, JangKeun Kim, Braden T. Tierney, Jiwoon Park, Nadia Houerbi, Alexander G. Lucaci, Sebastian Garcia Medina, Namita Damle, Deena Najjar, Kirill Grigorev, et al.Technologies PromethION and deep RNA-seq (more than 400 million reads per sample) on the Ultima Genomics UG100. These data quantified genes that were differentially expressed and displayed differential N6-methyladenosine

(17) Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responsesNature CommunicationsJune 11, 2024Kirill Grigorev, Theodore M. Nelson, Eliah G. Overbey, Nadia Houerbi, JangKeun Kim, Deena Najjar, Namita Damle, Evan E. Afshin, Krista A. Ryon, Jean Thierry-Mieg, et al.these isoforms, we performed deep RNA-seq on the same whole blood samples using the Ultima Genomics UG100 system. The platform generated an average of 411.5 million reads per sample, with a mapping percentage

(18) Genomic variant benchmark: if you cannot measure it, you cannot improve itGenome BiologyOctober 5, 2023Sina Majidian, Daniel Paiva Agustinho, Chen-Shan Chin, Fritz J. Sedlazeck, Medhat Mahmoudk,50ngj,$,N/A AVITI,Element,Element AVITI System,2*150 or 10 k,0.1–0.5,$,48a Ultima,Ultima Genomics,UG 100,300,0.25,$h,20 Sequencing by binding,PacBio (formerly Omniome),N/A,200,N/A,N/A,N/A Comparing different

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UG 100™ Sequencing Platform

UG 100™ Sequencing Platform from Ultima Genomics

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UG 100™ Sequencing Platform from Ultima Genomics

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