Description
Our team of synthetic organic and medicinal chemists brings decades of industry experience to perform complex, multi-step organic syntheses. Supported by our Medicinal Chemistry & Structure-Based Drug Design and GMP & Process Development Services, our team of highly skilled organic chemists possesses broad synthetic proficiencies beyond our core expertise in lipid, bioconjugate, and stable isotopic labeling chemistry.
Synthesis, Purification, and Characterization - Complex fatty acid metabolites, glycerophospholipids, sphingolipids, and sterols
- Small molecule, drug-like heterocyclic compounds
- Classic and emerging drugs of abuse including PEDs, LSD, amphetamines, benzodiazepines, synthetic cannabinoids, opioids, and more
- Stable isotope-labeled target standards
Analytical Standards Development- Analytical Standards
- Reference Materials
- Certified Reference Materials
Lipid Nanoparticle (LNP) Development- Custom LNP components including cationic lipids, neutral phospholipids, anionic lipids, sterols, and PEGylated lipids
- In vitro screening and characterization of LNP formulations
Small Molecule Analog Synthesis/SAR, Parallel Medicinal Chemistry, and Compound Library Generation - Hit-to-Lead: design, synthesis, and screening
- Lead optimization and scale-up
Specialized Syntheses - Bioconjugation
- Fluorescent dye design, development, and synthesis
- Selective, stable isotopic labeling
- Natural Product Chemistry: extraction from biological sources and total synthesis
GMP and Process Development - Chemical route exploration, development, and optimization
- Pre-clinical/clinical API synthesis and method validation
- Commercial GMP-API manufacturing